DegronMD - P52948(NUP98)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M1195I	TCGA-43-2581	LUSC	TCGA	FKVHLE	LIG_APCC_ABBA_1	1194:1199	Mutation altering degron motif	0.7618
p.M1195I	DO26602	LUSC	ICGC	FKVHLE	LIG_APCC_ABBA_1	1194:1199	Mutation altering degron motif	0.7618
p.R1506H	TCGA-AJ-A3EK	UCEC	TCGA	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation rewiring degron network	0.1944
p.R1506H	DO41584	UCEC	ICGC	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation rewiring degron network	0.1944
p.R1103C	TCGA-AN-A0AK	BRCA	TCGA	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1111
p.R1103C	DO1608	BRCA	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1111
p.R1124H	TCGA-AP-A059	UCEC	TCGA	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1944
p.R1124H	DO41361	UCEC	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1944
p.D1501Y	TCGA-BS-A0TJ	UCEC	TCGA	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation altering degron motif	0.7325
p.D1501Y	DO42953	UCEC	ICGC	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation altering degron motif	0.7325
p.A1084V	TCGA-CD-A4MG	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation altering degron motif	0.6936
p.A1084V	DO48009	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation altering degron motif	0.6936
p.R1496Q	TCGA-D1-A17Q	UCEC	TCGA	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation altering degron motif	0.7329
p.R1496Q	DO41903	UCEC	ICGC	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation altering degron motif	0.7329
p.S1185I	TCGA-D3-A2J6	SKCM	TCGA	FKVHLE	LIG_APCC_ABBA_1	1194:1199	Mutation rewiring degron network	0.0833
p.S1185I	DO37901	SKCM	ICGC	FKVHLE	LIG_APCC_ABBA_1	1194:1199	Mutation rewiring degron network	0.0833
p.V1087A	TCGA-EE-A29D	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.25
p.V1087A	DO38123	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.25
p.P1502S	TCGA-EE-A3J7	SKCM	TCGA	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation rewiring degron network	0.3056
p.P1502S	DO48770	SKCM	ICGC	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation rewiring degron network	0.3056
p.P1191S	TCGA-EO-A22R	UCEC	TCGA	FKVHLE	LIG_APCC_ABBA_1	1194:1199	Mutation rewiring degron network	0.25
p.P1191S	DO42713	UCEC	ICGC	FKVHLE	LIG_APCC_ABBA_1	1194:1199	Mutation rewiring degron network	0.25
p.R1124C	TCGA-EO-A3AZ	UCEC	TCGA	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1944
p.R1124C	DO50078	UCEC	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1944
p.R1127C	TCGA-ER-A198	SKCM	TCGA	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1111
p.R1127C	TCGA-FI-A2D5	UCEC	TCGA	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1111
p.R1127C	DO47563	SKCM	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1111
p.R1127C	DO41331	UCEC	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1111
p.P1088R	TCGA-FW-A3R5	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.2222
p.P1088R	DO37406	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.2222
p.S1082N	TCGA-G4-6317	COAD	TCGA	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation altering degron motif	0.7069
p.S1082N	DO10100	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation altering degron motif	0.7069
p.L1206F	TCGA-LG-A6GG	LIHC	TCGA	FKVHLE	LIG_APCC_ABBA_1	1194:1199	Mutation rewiring degron network	0.1389
p.L1206F	DO49699	LIHC	ICGC	FKVHLE	LIG_APCC_ABBA_1	1194:1199	Mutation rewiring degron network	0.1389
p.P1071S	TCGA-WE-AAA0	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.0833
p.P1071S	DO51294	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.0833
p.V1101I	DO48370	BLCA	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.0556
p.V1101I	SIDM00214	Colorectal Carcinoma	GDSC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.0556
p.V1101I	ACH-000955	Colon/Colorectal Cancer	CCLE	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.0556
p.V1101I	SNU-407	large intestine	COSMIC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.0556
p.N1490Y	DO52701	CLLE	ICGC	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation rewiring degron network	0.1667
p.M1118I	DO233764	GACA	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation altering degron motif	0.7618
p.G1129V	DO228924	LICA	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.0556
p.P232S	DO228944	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	232:236	Mutation altering degron motif	0.6752
p.P232S	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	232:236	Mutation altering degron motif	0.6752
p.P232S	ACH-000824	Esophageal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	232:236	Mutation altering degron motif	0.6752
p.P232S	KYSE-510	oesophagus	COSMIC	PATSS	DEG_SPOP_SBC_1	232:236	Mutation altering degron motif	0.6752
p.F1078C	DO228993	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.2778
p.T75S	DO229018	LICA	ICGC	PATST	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.6005
p.N217K	DO229022	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2222
p.P1201T	DO229036	LICA	ICGC	FKVHLE	LIG_APCC_ABBA_1	1194:1199	Mutation rewiring degron network	0.2778
p.T238K	DO229038	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.T225N	DO229045	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.7055
p.S67L	DO229446	SKCA	ICGC	PATST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2222
p.D1504G	DO229268	THCA	ICGC	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation blocking phosphorylation signal	0.6944
p.G214A	DO229211	THCA	ICGC	AGTTT	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1389
p.T238I	DO229245	THCA	ICGC	PATSS	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.I1498T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation altering degron motif	0.7078
p.I1498T	SIDM00650	Small Cell Lung Carcinoma	GDSC	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation altering degron motif	0.7078
p.I1498T	SIDM01681	Non-Cancerous	GDSC	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation altering degron motif	0.7078
p.R1103H	SIDM00072	Non-Cancerous	GDSC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1111
p.R1103H	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1111
p.R1103H	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.1111
p.T85A	SIDM00454	Rhabdomyosarcoma	GDSC	PATST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0556
p.T85A	SIDM01117	Small Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0556
p.T85A	SIDM00087	Plasma Cell Myeloma	GDSC	PATST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0556
p.T85A	SIDM00210	Ovarian Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0556
p.T85A	SIDM00721	Small Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0556
p.T85A	SIDM00628	Breast Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0556
p.S76G	SIDM00473	Oral Cavity Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.S76G	ACH-000619	Head and Neck Cancer	CCLE	PATST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.S76G	PE/CA-PJ15	upper aerodigestive tract	COSMIC	PATST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.P1088L	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.2222
p.P1088L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.2222
p.F1078L	SIDM00457	Plasma Cell Myeloma	GDSC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.2778
p.F1078L	ACH-000024	Myeloma	CCLE	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.2778
p.F1078L	ACH-000057	Myeloma	CCLE	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.2778
p.F1078L	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.2778
p.V1077M	SIDM00761	Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.25
p.V1077M	ACH-000752	Lung Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.25
p.V1077M	NCI-H196	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.25
p.A1119T	SIDM01619	Endometrial Carcinoma	GDSC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation altering degron motif	0.7139
p.A1119T	ACH-000984	Endometrial/Uterine Cancer	CCLE	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation altering degron motif	0.7139
p.M1122T	ACH-000973	Bladder Cancer	CCLE	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation substituting flanking lysine	0.3611
p.G214S	ACH-000982	Colon/Colorectal Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1389
p.R1120H	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation rewiring degron network	0.3056
p.P1188R	NCI-H196	lung	COSMIC	FKVHLE	LIG_APCC_ABBA_1	1194:1199	Mutation rewiring degron network	0.1667
p.E1493K	MCC13	skin	COSMIC	LKLYSD	LIG_APCC_ABBA_1	1496:1501	Mutation rewiring degron network	0.25
p.N1078T	A388	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.2778
p.V1094M	NCI-H196	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	1080:1084	Mutation rewiring degron network	0.0556
p.V1118I	SNU-407	large intestine	COSMIC	TRRQLGLVP	DEG_APCC_DBOX_1	1111:1119	Mutation altering degron motif	0.5965

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUP98

UniProt ID: P52948

Entrez ID: 4928

Protein name: Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUP98 in