DegronMD

Uniprot ID: P52948

Source protein: Nuclear pore complex protein Nup98-Nup96

Source gene: NUP98

Class: LIG_APCC_ABBA_1

Location: 1496:1501

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6209

ASA_SCORE: 22.8333

COIL: 0.3325

CONS_SCORE: 0.4599

DSS_SCORE: 0.0353

HELIX: 0.6557

FCONS_SCORE: 1.196

RIG_SCORE: 0.8517

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1506H	TCGA-AJ-A3EK	UCEC	TCGA	LKLYSD	LIG_APCC_ABBA_1	0.1944
p.R1506H	DO41584	UCEC	ICGC	LKLYSD	LIG_APCC_ABBA_1	0.1944
p.D1501Y	TCGA-BS-A0TJ	UCEC	TCGA	LKLYSD	LIG_APCC_ABBA_1	0.7325
p.D1501Y	DO42953	UCEC	ICGC	LKLYSD	LIG_APCC_ABBA_1	0.7325
p.R1496Q	TCGA-D1-A17Q	UCEC	TCGA	LKLYSD	LIG_APCC_ABBA_1	0.7329
p.R1496Q	DO41903	UCEC	ICGC	LKLYSD	LIG_APCC_ABBA_1	0.7329
p.P1502S	TCGA-EE-A3J7	SKCM	TCGA	LKLYSD	LIG_APCC_ABBA_1	0.3056
p.P1502S	DO48770	SKCM	ICGC	LKLYSD	LIG_APCC_ABBA_1	0.3056
p.N1490Y	DO52701	CLLE	ICGC	LKLYSD	LIG_APCC_ABBA_1	0.1667
p.D1504G	DO229268	THCA	ICGC	LKLYSD	LIG_APCC_ABBA_1	0.6944
p.I1498T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LKLYSD	LIG_APCC_ABBA_1	0.7078
p.I1498T	SIDM00650	Small Cell Lung Carcinoma	GDSC	LKLYSD	LIG_APCC_ABBA_1	0.7078
p.I1498T	SIDM01681	Non-Cancerous	GDSC	LKLYSD	LIG_APCC_ABBA_1	0.7078
p.E1493K	MCC13	skin	COSMIC	LKLYSD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95741	Copine-6	LIG_APCC_ABBA_1	46:51	LKLYSD	APC,CDC20,FZR1	0.5994	More...
P52948	Nuclear pore complex protein Nup98-Nup96	LIG_APCC_ABBA_1	1496:1501	LKLYSD	APC,CDC20,FZR1	0.6209	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons