DegronMD

Uniprot ID: O95741

Source protein: Copine-6

Source gene: CPNE6

Class: LIG_APCC_ABBA_1

Location: 46:51

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5994

ASA_SCORE: 55.6333

COIL: 0.3845

CONS_SCORE: 0.5043

DSS_SCORE: 0.0862

HELIX: 0.0082

FCONS_SCORE: 0.8504

RIG_SCORE: 0.8811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S50Y	TCGA-86-7701	LUAD	TCGA	LKLYSD	LIG_APCC_ABBA_1	0.6009
p.S50Y	DO24441	LUAD	ICGC	LKLYSD	LIG_APCC_ABBA_1	0.6009
p.E58D	TCGA-BR-4201	STAD	TCGA	LKLYSD	LIG_APCC_ABBA_1	0.1389
p.E58D	DO38707	STAD	ICGC	LKLYSD	LIG_APCC_ABBA_1	0.1389
p.L37I	DO229257	THCA	ICGC	LKLYSD	LIG_APCC_ABBA_1	0.0833
p.D50Y	SIDM00627	Cervical Carcinoma	GDSC	LKLYSD	LIG_APCC_ABBA_1	0.7325
p.L46I	ACH-000943	Colon/Colorectal Cancer	CCLE	LKLYSD	LIG_APCC_ABBA_1	0.6063
p.L46I	RKO	large_intestine	COSMIC	LKLYSD	LIG_APCC_ABBA_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95741	Copine-6	LIG_APCC_ABBA_1	46:51	LKLYSD	APC,CDC20,FZR1	0.5994	More...
P52948	Nuclear pore complex protein Nup98-Nup96	LIG_APCC_ABBA_1	1496:1501	LKLYSD	APC,CDC20,FZR1	0.6209	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons