DegronMD - O95741(CPNE6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P12A	TCGA-4R-AA8I	LIHC	TCGA	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation altering degron motif	0.6392
p.P12A	DO49657	LIHC	ICGC	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation altering degron motif	0.6392
p.S50Y	TCGA-86-7701	LUAD	TCGA	LKLYSD	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.6009
p.S50Y	DO24441	LUAD	ICGC	LKLYSD	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.6009
p.E58D	TCGA-BR-4201	STAD	TCGA	LKLYSD	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.1389
p.E58D	DO38707	STAD	ICGC	LKLYSD	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.1389
p.M6I	TCGA-DX-A8BP	SARC	TCGA	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation altering degron motif	0.6507
p.M6I	DO220056	SARC	ICGC	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation altering degron motif	0.6507
p.P13Q	TCGA-GN-A265	SKCM	TCGA	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation rewiring degron network	0.3056
p.P13Q	DO37491	SKCM	ICGC	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation rewiring degron network	0.3056
p.M15I	TCGA-L5-A4OE	ESCA	TCGA	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation rewiring degron network	0.25
p.V22L	TCGA-VQ-A8PK	STAD	TCGA	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation rewiring degron network	0.0556
p.V22L	DO51771	STAD	ICGC	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation rewiring degron network	0.0556
p.E5K	DO232224	PBCA	ICGC	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation altering degron motif	0.7022
p.P15L	DO38404	STAD	ICGC	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation rewiring degron network	0.25
p.L37I	DO229257	THCA	ICGC	LKLYSD	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.0833
p.R21W	DO43418	UCEC	ICGC	SDPEMGWVPEP	DEG_COP1_1	2:12	Mutation rewiring degron network	0.0833
p.D50Y	SIDM00627	Cervical Carcinoma	GDSC	LKLYSD	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.7325
p.L46I	ACH-000943	Colon/Colorectal Cancer	CCLE	LKLYSD	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.6063
p.L46I	RKO	large intestine	COSMIC	LKLYSD	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.6063

Kaplan plot for CPNE6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPNE6

UniProt ID: O95741

Entrez ID: 9362

Protein name: Copine-6 (Copine VI) (Neuronal-copine) (N-copine)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CPNE6 in