DegronMD

Uniprot ID: O95741

Source protein: Copine-6

Source gene: CPNE6

Class: DEG_COP1_1

Location: 2:12

E3 ligase: COP1

DEGRON score: 0.9285

ASA_SCORE: 83.9909

COIL: 0.9239

CONS_SCORE: 0.4721

DSS_SCORE: 0.7363

HELIX: 0.0472

FCONS_SCORE: 0.9856

RIG_SCORE: 0.691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P12A	TCGA-4R-AA8I	LIHC	TCGA	SDPEMGWVPEP	DEG_COP1_1	0.6392
p.P12A	DO49657	LIHC	ICGC	SDPEMGWVPEP	DEG_COP1_1	0.6392
p.M6I	TCGA-DX-A8BP	SARC	TCGA	SDPEMGWVPEP	DEG_COP1_1	0.6507
p.M6I	DO220056	SARC	ICGC	SDPEMGWVPEP	DEG_COP1_1	0.6507
p.P13Q	TCGA-GN-A265	SKCM	TCGA	SDPEMGWVPEP	DEG_COP1_1	0.3056
p.P13Q	DO37491	SKCM	ICGC	SDPEMGWVPEP	DEG_COP1_1	0.3056
p.M15I	TCGA-L5-A4OE	ESCA	TCGA	SDPEMGWVPEP	DEG_COP1_1	0.25
p.V22L	TCGA-VQ-A8PK	STAD	TCGA	SDPEMGWVPEP	DEG_COP1_1	0.0556
p.V22L	DO51771	STAD	ICGC	SDPEMGWVPEP	DEG_COP1_1	0.0556
p.E5K	DO232224	PBCA	ICGC	SDPEMGWVPEP	DEG_COP1_1	0.7022
p.P15L	DO38404	STAD	ICGC	SDPEMGWVPEP	DEG_COP1_1	0.25
p.R21W	DO43418	UCEC	ICGC	SDPEMGWVPEP	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95741	Copine-6	DEG_COP1_1	2:12	SDPEMGWVPEP	COP1	0.9285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons