DegronMD

Uniprot ID: P52948

Source protein: Nuclear pore complex protein Nup98-Nup96

Source gene: NUP98

Class: LIG_APCC_ABBA_1

Location: 1194:1199

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9654

ASA_SCORE: 55.15

COIL: 0.1332

CONS_SCORE: 0.2591

DSS_SCORE: 0.3362

HELIX: 0.0163

FCONS_SCORE: 0.9904

RIG_SCORE: 0.8072

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1195I	TCGA-43-2581	LUSC	TCGA	FKVHLE	LIG_APCC_ABBA_1	0.7618
p.M1195I	DO26602	LUSC	ICGC	FKVHLE	LIG_APCC_ABBA_1	0.7618
p.S1185I	TCGA-D3-A2J6	SKCM	TCGA	FKVHLE	LIG_APCC_ABBA_1	0.0833
p.S1185I	DO37901	SKCM	ICGC	FKVHLE	LIG_APCC_ABBA_1	0.0833
p.P1191S	TCGA-EO-A22R	UCEC	TCGA	FKVHLE	LIG_APCC_ABBA_1	0.25
p.P1191S	DO42713	UCEC	ICGC	FKVHLE	LIG_APCC_ABBA_1	0.25
p.L1206F	TCGA-LG-A6GG	LIHC	TCGA	FKVHLE	LIG_APCC_ABBA_1	0.1389
p.L1206F	DO49699	LIHC	ICGC	FKVHLE	LIG_APCC_ABBA_1	0.1389
p.P1201T	DO229036	LICA	ICGC	FKVHLE	LIG_APCC_ABBA_1	0.2778
p.P1188R	NCI-H196	lung	COSMIC	FKVHLE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52948	Nuclear pore complex protein Nup98-Nup96	LIG_APCC_ABBA_1	1194:1199	FKVHLE	APC,CDC20,FZR1	0.9654	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons