DegronMD

Uniprot ID: P52948

Source protein: Nuclear pore complex protein Nup98-Nup96

Source gene: NUP98

Class: DEG_APCC_DBOX_1

Location: 1111:1119

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9903

ASA_SCORE: 81.2

COIL: 0.731

CONS_SCORE: 0.2488

DSS_SCORE: 0.4328

HELIX: 0.1081

FCONS_SCORE: 0.9507

RIG_SCORE: 0.7805

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1103C	TCGA-AN-A0AK	BRCA	TCGA	TRRQLGLVP	DEG_APCC_DBOX_1	0.1111
p.R1103C	DO1608	BRCA	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	0.1111
p.R1124H	TCGA-AP-A059	UCEC	TCGA	TRRQLGLVP	DEG_APCC_DBOX_1	0.1944
p.R1124H	DO41361	UCEC	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	0.1944
p.R1124C	TCGA-EO-A3AZ	UCEC	TCGA	TRRQLGLVP	DEG_APCC_DBOX_1	0.1944
p.R1124C	DO50078	UCEC	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	0.1944
p.R1127C	TCGA-ER-A198	SKCM	TCGA	TRRQLGLVP	DEG_APCC_DBOX_1	0.1111
p.R1127C	TCGA-FI-A2D5	UCEC	TCGA	TRRQLGLVP	DEG_APCC_DBOX_1	0.1111
p.R1127C	DO47563	SKCM	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	0.1111
p.R1127C	DO41331	UCEC	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	0.1111
p.V1101I	DO48370	BLCA	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	0.0556
p.V1101I	SIDM00214	Colorectal Carcinoma	GDSC	TRRQLGLVP	DEG_APCC_DBOX_1	0.0556
p.V1101I	ACH-000955	Colon/Colorectal Cancer	CCLE	TRRQLGLVP	DEG_APCC_DBOX_1	0.0556
p.V1101I	SNU-407	large_intestine	COSMIC	TRRQLGLVP	DEG_APCC_DBOX_1	0.0556
p.M1118I	DO233764	GACA	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	0.7618
p.G1129V	DO228924	LICA	ICGC	TRRQLGLVP	DEG_APCC_DBOX_1	0.0556
p.R1103H	SIDM00072	Non-Cancerous	GDSC	TRRQLGLVP	DEG_APCC_DBOX_1	0.1111
p.R1103H	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	TRRQLGLVP	DEG_APCC_DBOX_1	0.1111
p.R1103H	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	TRRQLGLVP	DEG_APCC_DBOX_1	0.1111
p.A1119T	SIDM01619	Endometrial Carcinoma	GDSC	TRRQLGLVP	DEG_APCC_DBOX_1	0.7139
p.A1119T	ACH-000984	Endometrial/Uterine Cancer	CCLE	TRRQLGLVP	DEG_APCC_DBOX_1	0.7139
p.M1122T	ACH-000973	Bladder Cancer	CCLE	TRRQLGLVP	DEG_APCC_DBOX_1	0.3611
p.R1120H	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	TRRQLGLVP	DEG_APCC_DBOX_1	0.3056
p.V1118I	SNU-407	large_intestine	COSMIC	TRRQLGLVP	DEG_APCC_DBOX_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_APCC_DBOX_1	1111:1119	TRRQLGLVP	APC,CDC20,FZR1	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRRQLGLVP

Degron related mutations and impact score

Drug responses associated with NUP98 mutations

All proteins holding degron of TRRQLGLVP