DegronMD

Uniprot ID: Q15678

Source protein: Tyrosine-protein phosphatase non-receptor type 14

Source gene: PTPN14

Class: DEG_APCC_KENBOX_2

Location: 955:959

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8487

ASA_SCORE: 111.32

COIL: 0.9184

CONS_SCORE: 0.3489

DSS_SCORE: 0.3371

HELIX: 0.0414

FCONS_SCORE: 0.5432

RIG_SCORE: 0.771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E957V	TCGA-69-7978	LUAD	TCGA	TKENN	DEG_APCC_KENBOX_2	0.7693
p.E957V	DO24920	LUAD	ICGC	TKENN	DEG_APCC_KENBOX_2	0.7693
p.N959S	TCGA-AZ-4315	COAD	TCGA	TKENN	DEG_APCC_KENBOX_2	0.5958
p.N959S	DO8842	COAD	ICGC	TKENN	DEG_APCC_KENBOX_2	0.5958
p.R949Q	TCGA-BG-A0MQ	UCEC	TCGA	TKENN	DEG_APCC_KENBOX_2	0.1667
p.R949Q	DO228416	LICA	ICGC	TKENN	DEG_APCC_KENBOX_2	0.1667
p.R949Q	DO41127	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	0.1667
p.T960K	DO229041	LICA	ICGC	TKENN	DEG_APCC_KENBOX_2	0.3056
p.T955N	DO229041	LICA	ICGC	TKENN	DEG_APCC_KENBOX_2	0.5944
p.P954T	DO229045	LICA	ICGC	TKENN	DEG_APCC_KENBOX_2	0.3056
p.N948I	ACH-000872	Lung Cancer	CCLE	TKENN	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14161	ARF GTPase-activating protein GIT2	DEG_APCC_KENBOX_2	754:758	TKENN	APC,CDC20,FZR1	0.5272	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_APCC_KENBOX_2	955:959	TKENN	APC,CDC20,FZR1	0.8487	More...
Q2VWA4	SKI family transcriptional corepressor 2	DEG_APCC_KENBOX_2	875:879	TKENN	APC,CDC20,FZR1	0.7344	More...
Q9P2D0	Inhibitor of Bruton tyrosine kinase	DEG_APCC_KENBOX_2	1165:1169	TKENN	APC,CDC20,FZR1	0.9746	More...
Q8ND24	RING finger protein 214	DEG_APCC_KENBOX_2	58:62	TKENN	APC,CDC20,FZR1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons