DegronMD

Uniprot ID: Q8ND24

Source protein: RING finger protein 214

Source gene: RNF214

Class: DEG_APCC_KENBOX_2

Location: 58:62

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9956

ASA_SCORE: 104.24

COIL: 0.7194

CONS_SCORE: 0.3435

DSS_SCORE: 0.6528

HELIX: 0.246

FCONS_SCORE: 1.0152

RIG_SCORE: 0.6664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L67F	TCGA-AX-A2HC	UCEC	TCGA	TKENN	DEG_APCC_KENBOX_2	0.1944
p.L67F	DO41572	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	0.1944
p.R63I	TCGA-BS-A0UF	UCEC	TCGA	TKENN	DEG_APCC_KENBOX_2	0.3056
p.R63I	DO41488	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	0.3056
p.Q65E	DO1249	BRCA	ICGC	TKENN	DEG_APCC_KENBOX_2	0.25
p.D72G	DO7954	COAD	ICGC	TKENN	DEG_APCC_KENBOX_2	0.0556
p.T56S	DO222765	COCA	ICGC	TKENN	DEG_APCC_KENBOX_2	0.7222
p.K69N	DO36394	READ	ICGC	TKENN	DEG_APCC_KENBOX_2	0.1389
p.K69N	DO41488	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	0.1389
p.D66Y	DO43041	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	0.2222
p.I57V	SIDM00463	T-Lymphoblastic Leukemia	GDSC	TKENN	DEG_APCC_KENBOX_2	0.3056
p.I57V	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	TKENN	DEG_APCC_KENBOX_2	0.3056
p.Q72R	SIDM00587	Biliary Tract Carcinoma	GDSC	TKENN	DEG_APCC_KENBOX_2	0.0556
p.D64Y	MFE-319	endometrium	COSMIC	TKENN	DEG_APCC_KENBOX_2	0.2778
p.D66G	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	TKENN	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14161	ARF GTPase-activating protein GIT2	DEG_APCC_KENBOX_2	754:758	TKENN	APC,CDC20,FZR1	0.5272	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_APCC_KENBOX_2	955:959	TKENN	APC,CDC20,FZR1	0.8487	More...
Q2VWA4	SKI family transcriptional corepressor 2	DEG_APCC_KENBOX_2	875:879	TKENN	APC,CDC20,FZR1	0.7344	More...
Q9P2D0	Inhibitor of Bruton tyrosine kinase	DEG_APCC_KENBOX_2	1165:1169	TKENN	APC,CDC20,FZR1	0.9746	More...
Q8ND24	RING finger protein 214	DEG_APCC_KENBOX_2	58:62	TKENN	APC,CDC20,FZR1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons