DegronMD - Q9P2D0(IBTK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V953A	TCGA-86-7711	LUAD	TCGA	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.V953A	DO25717	LUAD	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.S1174I	TCGA-AA-3672	COAD	TCGA	TKENN	DEG_APCC_KENBOX_2	1165:1169	Mutation rewiring degron network	0.1944
p.S1174I	DO9010	COAD	ICGC	TKENN	DEG_APCC_KENBOX_2	1165:1169	Mutation rewiring degron network	0.1944
p.Y950C	TCGA-BA-A6DE	HNSC	TCGA	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation blocking phosphorylation signal	0.6111
p.Y950C	DO44438	HNSC	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation blocking phosphorylation signal	0.6111
p.M930I	TCGA-BF-A1PU	SKCM	TCGA	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.M930I	DO50278	SKCM	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.N1173Y	TCGA-CQ-5333	HNSC	TCGA	TKENN	DEG_APCC_KENBOX_2	1165:1169	Mutation rewiring degron network	0.2222
p.N1173Y	DO14218	HNSC	ICGC	TKENN	DEG_APCC_KENBOX_2	1165:1169	Mutation rewiring degron network	0.2222
p.Y950H	TCGA-DI-A1BU	UCEC	TCGA	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation blocking phosphorylation signal	0.6111
p.Y950H	DO42023	UCEC	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation blocking phosphorylation signal	0.6111
p.V953I	TCGA-DK-A1A7	BLCA	TCGA	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.V953I	DO483	BLCA	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.D947H	TCGA-DK-A3IV	BLCA	TCGA	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.25
p.D947H	DO467	BLCA	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.25
p.D935N	DO234162	ESAD	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.2222
p.Q1155R	DO234350	ESAD	ICGC	TKENN	DEG_APCC_KENBOX_2	1165:1169	Mutation rewiring degron network	0.0556
p.S949G	DO228228	LICA	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation blocking phosphorylation signal	0.6389
p.P946T	DO229029	LICA	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.2778
p.P946T	DO229027	LICA	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.2778
p.P941T	DO229045	LICA	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation altering degron motif	0.7031
p.R936S	DO229227	THCA	ICGC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.25
p.Q943E	SIDM00860	Head and Neck Carcinoma	GDSC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation altering degron motif	0.5633
p.Q943E	ACH-000846	Head and Neck Cancer	CCLE	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation altering degron motif	0.5633
p.Q943E	FADU	upper aerodigestive tract	COSMIC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation altering degron motif	0.5633
p.M930T	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.M930T	NCI-H647	lung	COSMIC	ITPYQD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.N1168S	SIDM01051	Ovarian Carcinoma	GDSC	TKENN	DEG_APCC_KENBOX_2	1165:1169	Mutation altering degron motif	0.7069
p.N1168S	SIDM01567	Hodgkin's Lymphoma	GDSC	TKENN	DEG_APCC_KENBOX_2	1165:1169	Mutation altering degron motif	0.7069

Kaplan plot for IBTK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IBTK

UniProt ID: Q9P2D0

Entrez ID: 25998

Protein name: Inhibitor of Bruton tyrosine kinase (IBtk)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IBTK in