DegronMD

Uniprot ID: Q9P2D0

Source protein: Inhibitor of Bruton tyrosine kinase

Source gene: IBTK

Class: LIG_APCC_ABBA_1

Location: 939:944

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5243

ASA_SCORE: 65.2833

COIL: 0.804

CONS_SCORE: 0.2935

DSS_SCORE: 0.297

HELIX: 0.127

FCONS_SCORE: 1.0809

RIG_SCORE: 0.7786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V953A	TCGA-86-7711	LUAD	TCGA	ITPYQD	LIG_APCC_ABBA_1	0.0833
p.V953A	DO25717	LUAD	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.0833
p.Y950C	TCGA-BA-A6DE	HNSC	TCGA	ITPYQD	LIG_APCC_ABBA_1	0.6111
p.Y950C	DO44438	HNSC	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.6111
p.M930I	TCGA-BF-A1PU	SKCM	TCGA	ITPYQD	LIG_APCC_ABBA_1	0.0833
p.M930I	DO50278	SKCM	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.0833
p.Y950H	TCGA-DI-A1BU	UCEC	TCGA	ITPYQD	LIG_APCC_ABBA_1	0.6111
p.Y950H	DO42023	UCEC	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.6111
p.V953I	TCGA-DK-A1A7	BLCA	TCGA	ITPYQD	LIG_APCC_ABBA_1	0.0833
p.V953I	DO483	BLCA	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.0833
p.D947H	TCGA-DK-A3IV	BLCA	TCGA	ITPYQD	LIG_APCC_ABBA_1	0.25
p.D947H	DO467	BLCA	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.25
p.D935N	DO234162	ESAD	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.2222
p.S949G	DO228228	LICA	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.6389
p.P946T	DO229029	LICA	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.2778
p.P946T	DO229027	LICA	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.2778
p.P941T	DO229045	LICA	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.7031
p.R936S	DO229227	THCA	ICGC	ITPYQD	LIG_APCC_ABBA_1	0.25
p.Q943E	SIDM00860	Head and Neck Carcinoma	GDSC	ITPYQD	LIG_APCC_ABBA_1	0.5633
p.Q943E	ACH-000846	Head and Neck Cancer	CCLE	ITPYQD	LIG_APCC_ABBA_1	0.5633
p.Q943E	FADU	upper_aerodigestive_tract	COSMIC	ITPYQD	LIG_APCC_ABBA_1	0.5633
p.M930T	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	ITPYQD	LIG_APCC_ABBA_1	0.0833
p.M930T	NCI-H647	lung	COSMIC	ITPYQD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2D0	Inhibitor of Bruton tyrosine kinase	LIG_APCC_ABBA_1	939:944	ITPYQD	APC,CDC20,FZR1	0.5243	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons