DegronMD

Uniprot ID: Q9P2D0

Source protein: Inhibitor of Bruton tyrosine kinase

Source gene: IBTK

Class: DEG_APCC_KENBOX_2

Location: 1165:1169

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9746

ASA_SCORE: 128.02

COIL: 0.8572

CONS_SCORE: 0.2734

DSS_SCORE: 0.5634

HELIX: 0.1328

FCONS_SCORE: 0.9143

RIG_SCORE: 0.7236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1174I	TCGA-AA-3672	COAD	TCGA	TKENN	DEG_APCC_KENBOX_2	0.1944
p.S1174I	DO9010	COAD	ICGC	TKENN	DEG_APCC_KENBOX_2	0.1944
p.N1173Y	TCGA-CQ-5333	HNSC	TCGA	TKENN	DEG_APCC_KENBOX_2	0.2222
p.N1173Y	DO14218	HNSC	ICGC	TKENN	DEG_APCC_KENBOX_2	0.2222
p.Q1155R	DO234350	ESAD	ICGC	TKENN	DEG_APCC_KENBOX_2	0.0556
p.N1168S	SIDM01051	Ovarian Carcinoma	GDSC	TKENN	DEG_APCC_KENBOX_2	0.7069
p.N1168S	SIDM01567	Hodgkin's Lymphoma	GDSC	TKENN	DEG_APCC_KENBOX_2	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14161	ARF GTPase-activating protein GIT2	DEG_APCC_KENBOX_2	754:758	TKENN	APC,CDC20,FZR1	0.5272	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_APCC_KENBOX_2	955:959	TKENN	APC,CDC20,FZR1	0.8487	More...
Q2VWA4	SKI family transcriptional corepressor 2	DEG_APCC_KENBOX_2	875:879	TKENN	APC,CDC20,FZR1	0.7344	More...
Q9P2D0	Inhibitor of Bruton tyrosine kinase	DEG_APCC_KENBOX_2	1165:1169	TKENN	APC,CDC20,FZR1	0.9746	More...
Q8ND24	RING finger protein 214	DEG_APCC_KENBOX_2	58:62	TKENN	APC,CDC20,FZR1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons