DegronMD

Uniprot ID: Q14161

Source protein: ARF GTPase-activating protein GIT2

Source gene: GIT2

Class: DEG_APCC_KENBOX_2

Location: 754:758

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5272

ASA_SCORE: 136.14

COIL: 0.8604

CONS_SCORE: 0.3618

DSS_SCORE: 0.6842

HELIX: 0.1338

FCONS_SCORE: 0.7022

RIG_SCORE: 0.7606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N758I	TCGA-17-Z061	LUAD	TCGA	TKENN	DEG_APCC_KENBOX_2	0.6169
p.L749P	TCGA-A5-A0G2	UCEC	TCGA	TKENN	DEG_APCC_KENBOX_2	0.1944
p.L749P	DO41235	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14161	ARF GTPase-activating protein GIT2	DEG_APCC_KENBOX_2	754:758	TKENN	APC,CDC20,FZR1	0.5272	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_APCC_KENBOX_2	955:959	TKENN	APC,CDC20,FZR1	0.8487	More...
Q2VWA4	SKI family transcriptional corepressor 2	DEG_APCC_KENBOX_2	875:879	TKENN	APC,CDC20,FZR1	0.7344	More...
Q9P2D0	Inhibitor of Bruton tyrosine kinase	DEG_APCC_KENBOX_2	1165:1169	TKENN	APC,CDC20,FZR1	0.9746	More...
Q8ND24	RING finger protein 214	DEG_APCC_KENBOX_2	58:62	TKENN	APC,CDC20,FZR1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons