DegronMD - Q8ND24(RNF214)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T141A	TCGA-33-AASD	LUSC	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.T141A	DO219127	LUSC	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.G138W	TCGA-86-7701	LUAD	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.G138W	DO24441	LUAD	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.R133W	TCGA-A2-A3Y0	BRCA	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.R133W	DO44273	BRCA	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.L459M	TCGA-AA-3715	COAD	TCGA	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation altering degron motif	0.711
p.R125Q	TCGA-AA-3966	COAD	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7329
p.R125Q	TCGA-B5-A3FC	UCEC	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7329
p.R125Q	DO10068	COAD	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7329
p.R125Q	DO41871	UCEC	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7329
p.R125Q	SIDM00217	Colorectal Carcinoma	GDSC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7329
p.R125Q	ACH-000999	Colon/Colorectal Cancer	CCLE	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7329
p.R125Q	SNU-1040	large intestine	COSMIC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7329
p.S134Y	TCGA-AG-3892	READ	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation blocking phosphorylation signal	0.7222
p.S134Y	DO36394	READ	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation blocking phosphorylation signal	0.7222
p.L67F	TCGA-AX-A2HC	UCEC	TCGA	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1944
p.L67F	DO41572	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1944
p.V475A	TCGA-B5-A1MR	UCEC	TCGA	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation rewiring degron network	0.25
p.R63I	TCGA-BS-A0UF	UCEC	TCGA	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.3056
p.R63I	DO41488	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.3056
p.R462Q	TCGA-EY-A2OM	UCEC	TCGA	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation altering degron motif	0.6218
p.E29K	TCGA-G2-A2EL	BLCA	TCGA	PESSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1111
p.E29K	DO478	BLCA	ICGC	PESSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1111
p.R462W	TCGA-N8-A4PO	UCS	TCGA	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation altering degron motif	0.7523
p.I467T	TCGA-SC-A6LM	MESO	TCGA	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation altering degron motif	0.5966
p.Q65E	DO1249	BRCA	ICGC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.25
p.R131Q	DO222404	BTCA	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7329
p.T459P	DO8018	COAD	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation altering degron motif	0.7031
p.D72G	DO7954	COAD	ICGC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.0556
p.V475I	DO7828	COAD	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation rewiring degron network	0.25
p.V475I	DO37435	SKCM	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation rewiring degron network	0.25
p.V475I	DO50140	STAD	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation rewiring degron network	0.25
p.T56S	DO222765	COCA	ICGC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation blocking phosphorylation signal	0.7222
p.P14H	DO234199	ESAD	ICGC	PESSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.R125W	DO234303	ESAD	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.8634
p.R454W	DO233935	GACA	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation rewiring degron network	0.1944
p.V455M	DO14250	HNSC	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation rewiring degron network	0.2222
p.D121Y	DO228986	LICA	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.25
p.C23F	DO229045	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.M470I	DO23590	LUAD	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation altering degron motif	0.7618
p.S20F	DO228889	MALY	ICGC	PESSS	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.9093
p.K115R	DO32173	OV	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.R131W	DO228138	PBCA	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.8634
p.K69N	DO36394	READ	ICGC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1389
p.K69N	DO41488	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.1389
p.P477H	DO37431	SKCM	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation rewiring degron network	0.1944
p.R454Q	DO50127	STAD	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation rewiring degron network	0.1944
p.K122M	DO229213	THCA	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2778
p.N116S	DO50075	UCEC	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.Q125H	DO42312	UCEC	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7582
p.D66Y	DO43041	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.2222
p.M472V	SIDM01649	Non-Cancerous	GDSC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation altering degron motif	0.6097
p.M472V	SIDM00184	Melanoma	GDSC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation altering degron motif	0.6097
p.I57V	SIDM00463	T-Lymphoblastic Leukemia	GDSC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.3056
p.I57V	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.3056
p.Q72R	SIDM00587	Biliary Tract Carcinoma	GDSC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.0556
p.D121H	SIDM00294	Small Cell Lung Carcinoma	GDSC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.25
p.D121H	ACH-001549	Lung Cancer	CCLE	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.25
p.D121H	LU-135	lung	COSMIC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.25
p.A11T	ACH-001061	Colon/Colorectal Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1667
p.L121I	SNU-1040	large intestine	COSMIC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.25
p.D64Y	MFE-319	endometrium	COSMIC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.2778
p.K122E	NUGC-3	stomach	COSMIC	LRESLHPVT	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2778
p.D66G	KM-H2	haematopoietic and lymphoid tissue	COSMIC	TKENN	DEG_APCC_KENBOX_2	58:62	Mutation rewiring degron network	0.2222
p.R466W	NCI-H1703	lung	COSMIC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	459:472	Mutation altering degron motif	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF214

UniProt ID: Q8ND24

Entrez ID: 257160

Protein name: RING finger protein 214

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF214 in