DegronMD

Uniprot ID: Q8ND24

Source protein: RING finger protein 214

Source gene: RNF214

Class: DEG_ODPH_VHL_1

Location: 459:472

E3 ligase: VHL

DEGRON score: 0.9923

ASA_SCORE: 78.0857

COIL: 0.9025

CONS_SCORE: 0.6103

DSS_SCORE: 0.4038

HELIX: 0.0341

FCONS_SCORE: 0.9484

RIG_SCORE: 0.7135

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L459M	TCGA-AA-3715	COAD	TCGA	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.711
p.V475A	TCGA-B5-A1MR	UCEC	TCGA	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.25
p.R462Q	TCGA-EY-A2OM	UCEC	TCGA	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.6218
p.R462W	TCGA-N8-A4PO	UCS	TCGA	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.7523
p.I467T	TCGA-SC-A6LM	MESO	TCGA	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.5966
p.T459P	DO8018	COAD	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.7031
p.V475I	DO7828	COAD	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.25
p.V475I	DO37435	SKCM	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.25
p.V475I	DO50140	STAD	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.25
p.R454W	DO233935	GACA	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.1944
p.V455M	DO14250	HNSC	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.2222
p.M470I	DO23590	LUAD	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.7618
p.P477H	DO37431	SKCM	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.1944
p.R454Q	DO50127	STAD	ICGC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.1944
p.M472V	SIDM01649	Non-Cancerous	GDSC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.6097
p.M472V	SIDM00184	Melanoma	GDSC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.6097
p.R466W	NCI-H1703	lung	COSMIC	LAPRMPFSIGQVTM	DEG_ODPH_VHL_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8ND24	RING finger protein 214	DEG_ODPH_VHL_1	459:472	LAPRMPFSIGQVTM	VHL	0.9923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons