DegronMD

Uniprot ID: Q8ND24

Source protein: RING finger protein 214

Source gene: RNF214

Class: DEG_APCC_DBOX_1

Location: 124:132

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.976

ASA_SCORE: 87.3222

COIL: 0.7611

CONS_SCORE: 0.4147

DSS_SCORE: 0.5645

HELIX: 0.1753

FCONS_SCORE: 0.9966

RIG_SCORE: 0.712

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T141A	TCGA-33-AASD	LUSC	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	0.0833
p.T141A	DO219127	LUSC	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.0833
p.G138W	TCGA-86-7701	LUAD	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	0.1667
p.G138W	DO24441	LUAD	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.1667
p.R133W	TCGA-A2-A3Y0	BRCA	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	0.3056
p.R133W	DO44273	BRCA	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.3056
p.R125Q	TCGA-AA-3966	COAD	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	0.7329
p.R125Q	TCGA-B5-A3FC	UCEC	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	0.7329
p.R125Q	DO10068	COAD	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.7329
p.R125Q	DO41871	UCEC	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.7329
p.R125Q	SIDM00217	Colorectal Carcinoma	GDSC	LRESLHPVT	DEG_APCC_DBOX_1	0.7329
p.R125Q	ACH-000999	Colon/Colorectal Cancer	CCLE	LRESLHPVT	DEG_APCC_DBOX_1	0.7329
p.R125Q	SNU-1040	large_intestine	COSMIC	LRESLHPVT	DEG_APCC_DBOX_1	0.7329
p.S134Y	TCGA-AG-3892	READ	TCGA	LRESLHPVT	DEG_APCC_DBOX_1	0.7222
p.S134Y	DO36394	READ	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.7222
p.R131Q	DO222404	BTCA	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.7329
p.R125W	DO234303	ESAD	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.8634
p.D121Y	DO228986	LICA	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.25
p.K115R	DO32173	OV	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.0833
p.R131W	DO228138	PBCA	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.8634
p.K122M	DO229213	THCA	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.2778
p.N116S	DO50075	UCEC	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.1111
p.Q125H	DO42312	UCEC	ICGC	LRESLHPVT	DEG_APCC_DBOX_1	0.7582
p.D121H	SIDM00294	Small Cell Lung Carcinoma	GDSC	LRESLHPVT	DEG_APCC_DBOX_1	0.25
p.D121H	ACH-001549	Lung Cancer	CCLE	LRESLHPVT	DEG_APCC_DBOX_1	0.25
p.D121H	LU-135	lung	COSMIC	LRESLHPVT	DEG_APCC_DBOX_1	0.25
p.L121I	SNU-1040	large_intestine	COSMIC	LRESLHPVT	DEG_APCC_DBOX_1	0.25
p.K122E	NUGC-3	stomach	COSMIC	LRESLHPVT	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRESLHPVT

Degron related mutations and impact score

Drug responses associated with RNF214 mutations

All proteins holding degron of LRESLHPVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8ND24	RING finger protein 214	DEG_APCC_DBOX_1	124:132	LRESLHPVT	APC,CDC20,FZR1	0.976	More...