DegronMD

Uniprot ID: Q2VWA4

Source protein: SKI family transcriptional corepressor 2

Source gene: SKOR2

Class: DEG_APCC_KENBOX_2

Location: 875:879

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7344

ASA_SCORE: 97

COIL: 0.6858

CONS_SCORE: 0.4295

DSS_SCORE: 0.6515

HELIX: 0.2742

FCONS_SCORE: 1.0376

RIG_SCORE: 0.6754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D887N	DO220872	MELA	ICGC	TKENN	DEG_APCC_KENBOX_2	0.1111
p.V883I	DO37782	SKCM	ICGC	TKENN	DEG_APCC_KENBOX_2	0.2222
p.D887V	ACH-000594	Lung Cancer	CCLE	TKENN	DEG_APCC_KENBOX_2	0.1111
p.P867H	ACH-000921	Lung Cancer	CCLE	TKENN	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14161	ARF GTPase-activating protein GIT2	DEG_APCC_KENBOX_2	754:758	TKENN	APC,CDC20,FZR1	0.5272	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_APCC_KENBOX_2	955:959	TKENN	APC,CDC20,FZR1	0.8487	More...
Q2VWA4	SKI family transcriptional corepressor 2	DEG_APCC_KENBOX_2	875:879	TKENN	APC,CDC20,FZR1	0.7344	More...
Q9P2D0	Inhibitor of Bruton tyrosine kinase	DEG_APCC_KENBOX_2	1165:1169	TKENN	APC,CDC20,FZR1	0.9746	More...
Q8ND24	RING finger protein 214	DEG_APCC_KENBOX_2	58:62	TKENN	APC,CDC20,FZR1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons