DegronMD - Q14161(GIT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N758I	TCGA-17-Z061	LUAD	TCGA	TKENN	DEG_APCC_KENBOX_2	754:758	Mutation altering degron motif	0.6169
p.L749P	TCGA-A5-A0G2	UCEC	TCGA	TKENN	DEG_APCC_KENBOX_2	754:758	Mutation rewiring degron network	0.1944
p.L749P	DO41235	UCEC	ICGC	TKENN	DEG_APCC_KENBOX_2	754:758	Mutation rewiring degron network	0.1944
p.A296S	TCGA-A5-A0G2	UCEC	TCGA	MDVYDE	LIG_APCC_ABBA_1	283:288	Mutation rewiring degron network	0.1111
p.P545S	TCGA-D3-A8GI	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.0833
p.P545S	DO50284	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.0833
p.H276N	TCGA-EE-A183	SKCM	TCGA	MDVYDE	LIG_APCC_ABBA_1	283:288	Mutation rewiring degron network	0.1389
p.S568Y	TCGA-EJ-7317	PRAD	TCGA	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation blocking phosphorylation signal	0.5
p.S568Y	TCGA-ZF-AA4W	BLCA	TCGA	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation blocking phosphorylation signal	0.5
p.A552V	DO229005	COCA	ICGC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.2778
p.A552V	DO229353	LAML	ICGC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.2778
p.A552V	DO52365	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.2778
p.D284N	DO228655	LICA	ICGC	MDVYDE	LIG_APCC_ABBA_1	283:288	Mutation altering degron motif	0.5821
p.Q562K	DO229018	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation blocking phosphorylation signal	0.6667
p.P564T	DO229038	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.1667
p.N547I	DO231155	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.1389
p.H278N	DO37715	SKCM	ICGC	MDVYDE	LIG_APCC_ABBA_1	283:288	Mutation rewiring degron network	0.1944
p.A298S	DO41235	UCEC	ICGC	MDVYDE	LIG_APCC_ABBA_1	283:288	Mutation rewiring degron network	0.0556
p.V285M	SIDM00082	Melanoma	GDSC	MDVYDE	LIG_APCC_ABBA_1	283:288	Mutation altering degron motif	0.6097
p.V285M	SK-MEL-2	skin	COSMIC	MDVYDE	LIG_APCC_ABBA_1	283:288	Mutation altering degron motif	0.6097
p.F544L	SIDM00881	Breast Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.0556
p.F544L	ACH-000352	Breast Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.0556
p.F544L	HCC1428	breast	COSMIC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.0556
p.V554A	SIDM01128	Small Cell Lung Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.5825
p.V554A	ACH-000767	Lung Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.5825
p.V554A	NCI-H526	lung	COSMIC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.5825
p.G549R	SIDM01700	Hodgkin's Lymphoma	GDSC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.1944
p.G549R	ACH-000165	Non-Cancerous	CCLE	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.1944
p.S561N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.25
p.V284M	SK-MEL-2	skin	COSMIC	MDVYDE	LIG_APCC_ABBA_1	283:288	Mutation altering degron motif	0.7208
p.D551E	HuH-7	liver	COSMIC	VTSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.25
p.V287M	SK-MEL-2	skin	COSMIC	MDVYDE	LIG_APCC_ABBA_1	283:288	Mutation altering degron motif	0.7208

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GIT2

UniProt ID: Q14161

Entrez ID: 9815

Protein name: ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GIT2 in