DegronMD

Uniprot ID: Q14161

Source protein: ARF GTPase-activating protein GIT2

Source gene: GIT2

Class: LIG_APCC_ABBA_1

Location: 283:288

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5665

ASA_SCORE: 80.85

COIL: 0.3815

CONS_SCORE: 0.6848

DSS_SCORE: 0.225

HELIX: 0.5973

FCONS_SCORE: 1.1777

RIG_SCORE: 0.8521

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A296S	TCGA-A5-A0G2	UCEC	TCGA	MDVYDE	LIG_APCC_ABBA_1	0.1111
p.H276N	TCGA-EE-A183	SKCM	TCGA	MDVYDE	LIG_APCC_ABBA_1	0.1389
p.D284N	DO228655	LICA	ICGC	MDVYDE	LIG_APCC_ABBA_1	0.5821
p.H278N	DO37715	SKCM	ICGC	MDVYDE	LIG_APCC_ABBA_1	0.1944
p.A298S	DO41235	UCEC	ICGC	MDVYDE	LIG_APCC_ABBA_1	0.0556
p.V285M	SIDM00082	Melanoma	GDSC	MDVYDE	LIG_APCC_ABBA_1	0.6097
p.V285M	SK-MEL-2	skin	COSMIC	MDVYDE	LIG_APCC_ABBA_1	0.6097
p.V284M	SK-MEL-2	skin	COSMIC	MDVYDE	LIG_APCC_ABBA_1	0.7208
p.V287M	SK-MEL-2	skin	COSMIC	MDVYDE	LIG_APCC_ABBA_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14161	ARF GTPase-activating protein GIT2	LIG_APCC_ABBA_1	283:288	MDVYDE	APC,CDC20,FZR1	0.5665	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons