DegronMD

Uniprot ID: Q14161

Source protein: ARF GTPase-activating protein GIT2

Source gene: GIT2

Class: DEG_SPOP_SBC_1

Location: 554:558

E3 ligase: SPOP

DEGRON score: 0.9992

ASA_SCORE: 71.92

COIL: 0.763

CONS_SCORE: 0.3961

DSS_SCORE: 0.4452

HELIX: 0.0762

FCONS_SCORE: 1.0346

RIG_SCORE: 0.646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P545S	TCGA-D3-A8GI	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	0.0833
p.P545S	DO50284	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	0.0833
p.S568Y	TCGA-EJ-7317	PRAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.5
p.S568Y	TCGA-ZF-AA4W	BLCA	TCGA	VTSSS	DEG_SPOP_SBC_1	0.5
p.A552V	DO229005	COCA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.2778
p.A552V	DO229353	LAML	ICGC	VTSSS	DEG_SPOP_SBC_1	0.2778
p.A552V	DO52365	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.2778
p.Q562K	DO229018	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.6667
p.P564T	DO229038	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.N547I	DO231155	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.F544L	SIDM00881	Breast Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.0556
p.F544L	ACH-000352	Breast Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.0556
p.F544L	HCC1428	breast	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.0556
p.V554A	SIDM01128	Small Cell Lung Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.5825
p.V554A	ACH-000767	Lung Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.5825
p.V554A	NCI-H526	lung	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.5825
p.G549R	SIDM01700	Hodgkin's Lymphoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.G549R	ACH-000165	Non-Cancerous	CCLE	VTSSS	DEG_SPOP_SBC_1	0.1944
p.S561N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.25
p.D551E	HuH-7	liver	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60318	Germinal-center associated nuclear protein	DEG_SPOP_SBC_1	197:201	VTSSS	SPOP	0.938	More...
P02533	Keratin, type I cytoskeletal 14	DEG_SPOP_SBC_1	441:445	VTSSS	SPOP	0.9845	More...
P15056	Serine/threonine-protein kinase B-raf	DEG_SPOP_SBC_1	120:124	VTSSS	SPOP	0.9734	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	207:211	VTSSS	SPOP	0.9601	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	2008:2012	VTSSS	SPOP	0.9659	More...
Q14161	ARF GTPase-activating protein GIT2	DEG_SPOP_SBC_1	554:558	VTSSS	SPOP	0.9992	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	3641:3645	VTSSS	SPOP	0.8527	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3548:3552	VTSSS	SPOP	0.9001	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	442:446	VTSSS	SPOP	0.9354	More...
Q8IY22	C-Maf-inducing protein	DEG_SPOP_SBC_1	3:7	VTSSS	SPOP	0.9749	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	108:112	VTSSS	SPOP	0.9792	More...
Q8TF40	Folliculin-interacting protein 1	DEG_SPOP_SBC_1	104:108	VTSSS	SPOP	0.9551	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3897:3901	VTSSS	SPOP	0.9951	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4932:4936	VTSSS	SPOP	0.8363	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7283:7287	VTSSS	SPOP	0.9977	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8158:8162	VTSSS	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11046:11050	VTSSS	SPOP	0.9225	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	565:569	VTSSS	SPOP	0.9982	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1615:1619	VTSSS	SPOP	0.8983	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	965:969	VTSSS	SPOP	0.9734	More...
A6NNH2	Protein FAM90A27P	DEG_SPOP_SBC_1	449:453	VTSSS	SPOP	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSSS

Degron related mutations and impact score

Drug responses associated with GIT2 mutations

All proteins holding degron of VTSSS