DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 4932:4936

E3 ligase: SPOP

DEGRON score: 0.8363

ASA_SCORE: 83.14

COIL: 0.8802

CONS_SCORE: 0

DSS_SCORE: 0.602

HELIX: 0.0194

FCONS_SCORE: 0

RIG_SCORE: 0.6586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D4944G	TCGA-18-3406	LUSC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1111
p.D4944G	DO26438	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1111
p.S4937R	TCGA-AA-3510	COAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.3056
p.S4937R	DO7783	COAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.3056
p.A4923T	TCGA-AA-3984	COAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.0833
p.A4923T	DO9002	COAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.0833
p.A4923V	TCGA-B5-A3FC	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.0833
p.A4923V	DO41871	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.0833
p.P4941T	TCGA-BS-A0UF	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1944
p.P4941T	DO41488	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.P4943L	TCGA-DA-A3F5	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1389
p.P4943L	DO37435	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.P4941S	TCGA-GN-A26C	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1944
p.P4941S	DO37782	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.V4927A	TCGA-MP-A4T6	LUAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1944
p.V4927A	DO45395	LUAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.D4944Y	DO223003	ESCA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1111
p.T4933I	DO11854	GBM	ICGC	VTSSS	DEG_SPOP_SBC_1	0.5966
p.T4930K	DO228948	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.2778
p.S4939F	DO220911	MELA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.25
p.R4929K	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.25
p.R4929K	ACH-000747	Lung Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.25
p.R4929K	NCI-H1703	lung	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60318	Germinal-center associated nuclear protein	DEG_SPOP_SBC_1	197:201	VTSSS	SPOP	0.938	More...
P02533	Keratin, type I cytoskeletal 14	DEG_SPOP_SBC_1	441:445	VTSSS	SPOP	0.9845	More...
P15056	Serine/threonine-protein kinase B-raf	DEG_SPOP_SBC_1	120:124	VTSSS	SPOP	0.9734	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	207:211	VTSSS	SPOP	0.9601	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	2008:2012	VTSSS	SPOP	0.9659	More...
Q14161	ARF GTPase-activating protein GIT2	DEG_SPOP_SBC_1	554:558	VTSSS	SPOP	0.9992	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	3641:3645	VTSSS	SPOP	0.8527	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3548:3552	VTSSS	SPOP	0.9001	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	442:446	VTSSS	SPOP	0.9354	More...
Q8IY22	C-Maf-inducing protein	DEG_SPOP_SBC_1	3:7	VTSSS	SPOP	0.9749	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	108:112	VTSSS	SPOP	0.9792	More...
Q8TF40	Folliculin-interacting protein 1	DEG_SPOP_SBC_1	104:108	VTSSS	SPOP	0.9551	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3897:3901	VTSSS	SPOP	0.9951	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4932:4936	VTSSS	SPOP	0.8363	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7283:7287	VTSSS	SPOP	0.9977	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8158:8162	VTSSS	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11046:11050	VTSSS	SPOP	0.9225	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	565:569	VTSSS	SPOP	0.9982	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1615:1619	VTSSS	SPOP	0.8983	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	965:969	VTSSS	SPOP	0.9734	More...
A6NNH2	Protein FAM90A27P	DEG_SPOP_SBC_1	449:453	VTSSS	SPOP	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VTSSS