DegronMD - P15056(BRAF)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S113I	TCGA-44-3918	LUAD	TCGA	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.S113I	DO23732	LUAD	ICGC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.S112C	TCGA-5L-AAT1	BRCA	TCGA	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.S112C	DO219594	BRCA	ICGC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.M117T	TCGA-B5-A3FA	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.25
p.M117T	DO52402	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.25
p.T401I	TCGA-EA-A1QT	CESC	TCGA	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.8189
p.T401I	DO6302	CESC	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.8189
p.R389C	TCGA-EO-A22X	UCEC	TCGA	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.0833
p.R389C	TCGA-F5-6814	READ	TCGA	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.0833
p.R389C	DO36556	READ	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.0833
p.R389C	DO43907	UCEC	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.0833
p.F388L	TCGA-F7-A624	HNSC	TCGA	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.0556
p.F388L	DO44440	HNSC	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.0556
p.S129L	TCGA-G2-A2EL	BLCA	TCGA	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944
p.S129L	DO478	BLCA	ICGC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944
p.T401A	TCGA-KK-A59V	PRAD	TCGA	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.825
p.T401A	DO51346	PRAD	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.825
p.G397S	TCGA-MN-A4N1	LUAD	TCGA	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.3056
p.G397S	DO45328	LUAD	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.3056
p.M117I	TCGA-TS-A7P8	MESO	TCGA	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.25
p.R389H	DO233791	GACA	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.0833
p.A404D	DO229025	LICA	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.6682
p.R389S	DO229035	LICA	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.0833
p.S127R	DO229008	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.25
p.S394T	DO52693	MALY	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation blocking phosphorylation signal	0.6667
p.L410Q	DO232468	PBCA	ICGC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1944
p.A115V	SIDM00889	Cervical Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944
p.A115V	ACH-001333	Cervical Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944
p.A115V	C-33-A	cervix	COSMIC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944
p.T119S	SIDM00136	Colorectal Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation blocking phosphorylation signal	0.75
p.T119S	ACH-000552	Colon/Colorectal Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation blocking phosphorylation signal	0.75
p.T119S	HT-29	large intestine	COSMIC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation blocking phosphorylation signal	0.75
p.A400V	SIDM01146	Gastric Carcinoma	GDSC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.5825
p.A400V	ACH-000932	Gastric Cancer	CCLE	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.5825
p.A400V	NCI-SNU-1	stomach	COSMIC	LSATPPAS	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.5825
p.V120I	SIDM00217	Colorectal Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7076
p.V120I	ACH-000999	Colon/Colorectal Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7076
p.V120I	SNU-1040	large intestine	COSMIC	VTSSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7076

Kaplan plot for BRAF in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRAF

UniProt ID: P15056

Entrez ID: 673

Protein name: Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BRAF in