DegronMD

Uniprot ID: P15056

Source protein: Serine/threonine-protein kinase B-raf

Source gene: BRAF

Class: DEG_SCF_FBW7_1

Location: 398:405

E3 ligase: FBXW7

DEGRON score: 0.9884

ASA_SCORE: 70.375

COIL: 0.8975

CONS_SCORE: 0.2878

DSS_SCORE: 0.6685

HELIX: 0.0425

FCONS_SCORE: 0.9688

RIG_SCORE: 0.628

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T401I	TCGA-EA-A1QT	CESC	TCGA	LSATPPAS	DEG_SCF_FBW7_1	0.8189
p.T401I	DO6302	CESC	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.8189
p.R389C	TCGA-EO-A22X	UCEC	TCGA	LSATPPAS	DEG_SCF_FBW7_1	0.0833
p.R389C	TCGA-F5-6814	READ	TCGA	LSATPPAS	DEG_SCF_FBW7_1	0.0833
p.R389C	DO36556	READ	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.0833
p.R389C	DO43907	UCEC	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.0833
p.F388L	TCGA-F7-A624	HNSC	TCGA	LSATPPAS	DEG_SCF_FBW7_1	0.0556
p.F388L	DO44440	HNSC	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.0556
p.T401A	TCGA-KK-A59V	PRAD	TCGA	LSATPPAS	DEG_SCF_FBW7_1	0.825
p.T401A	DO51346	PRAD	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.825
p.G397S	TCGA-MN-A4N1	LUAD	TCGA	LSATPPAS	DEG_SCF_FBW7_1	0.3056
p.G397S	DO45328	LUAD	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.3056
p.R389H	DO233791	GACA	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.0833
p.A404D	DO229025	LICA	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.6682
p.R389S	DO229035	LICA	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.0833
p.S394T	DO52693	MALY	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.6667
p.L410Q	DO232468	PBCA	ICGC	LSATPPAS	DEG_SCF_FBW7_1	0.1944
p.A400V	SIDM01146	Gastric Carcinoma	GDSC	LSATPPAS	DEG_SCF_FBW7_1	0.5825
p.A400V	ACH-000932	Gastric Cancer	CCLE	LSATPPAS	DEG_SCF_FBW7_1	0.5825
p.A400V	NCI-SNU-1	stomach	COSMIC	LSATPPAS	DEG_SCF_FBW7_1	0.5825

Drug responses associated with BRAF mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000962	Ovarian Cancer	p.A747V (No)	CCLE	PLX4720	8
ACH-000962	Ovarian Cancer	p.A747V (No)	CCLE	RAF265	3.6721
ACH-001145	Ovarian Cancer	p.A747V (No)	CCLE	PLX4720	8
ACH-001145	Ovarian Cancer	p.A747V (No)	CCLE	RAF265	3.0296
ACH-000995	Leukemia	p.A728V (No)	CCLE	PLX4720	3.7589
ACH-000995	Leukemia	p.A728V (No)	CCLE	RAF265	0.3566
ACH-000988	Endometrial/Uterine Cancer	p.S727G (No)	CCLE	PLX4720	8
ACH-000890	Lung Cancer	p.S683N (No)	CCLE	PLX4720	8
ACH-000890	Lung Cancer	p.S683N (No)	CCLE	RAF265	3.4915
ACH-000941	Endometrial/Uterine Cancer	p.R682Q (No)	CCLE	PLX4720	8
ACH-000941	Endometrial/Uterine Cancer	p.R682Q (No)	CCLE	RAF265	8
ACH-000954	Endometrial/Uterine Cancer	p.R682Q (No)	CCLE	PLX4720	8
ACH-000954	Endometrial/Uterine Cancer	p.R682Q (No)	CCLE	RAF265	2.657
ACH-000862	Bladder Cancer	p.M650I (No)	CCLE	PLX4720	8
ACH-000862	Bladder Cancer	p.M650I (No)	CCLE	RAF265	4.1045
ACH-000346	Leukemia	p.K601N (No)	CCLE	PLX4720	3.7271
ACH-000346	Leukemia	p.K601N (No)	CCLE	RAF265	0.13
ACH-000304	Skin Cancer	p.V600D (No)	CCLE	PLX4720	8
ACH-000304	Skin Cancer	p.V600D (No)	CCLE	RAF265	2.8096
ACH-001239	Skin Cancer	p.V600D (No)	CCLE	PLX4720	1.5787
ACH-001239	Skin Cancer	p.V600D (No)	CCLE	RAF265	1.2205
ACH-000014	Metastasis	p.V600E (No)	CCLE	PLX4720	8
ACH-000014	Metastasis	p.V600E (No)	CCLE	RAF265	2.9046
ACH-000052	Bone Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000052	Bone Cancer	p.V600E (No)	CCLE	RAF265	0.8097
ACH-000112	Leukemia	p.V600E (No)	CCLE	PLX4720	0.0336
ACH-000112	Leukemia	p.V600E (No)	CCLE	RAF265	0.1571
ACH-000219	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.2583
ACH-000219	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.6227
ACH-000236	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	2.2788
ACH-000236	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	0.2024
ACH-000253	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	0.6257
ACH-000253	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	0.4351
ACH-000304	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000304	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.8096
ACH-000322	Skin Cancer	p.V600E (No)	CCLE	PLX4720	1.3363
ACH-000322	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.3401
ACH-000348	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000348	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.4054
ACH-000361	Liver Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000361	Liver Cancer	p.V600E (No)	CCLE	RAF265	0.174
ACH-000404	Skin Cancer	p.V600E (No)	CCLE	PLX4720	2.1106
ACH-000404	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.7067
ACH-000425	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.2497
ACH-000425	Skin Cancer	p.V600E (No)	CCLE	RAF265	1.0647
ACH-000450	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.313
ACH-000450	Skin Cancer	p.V600E (No)	CCLE	RAF265	1.1835
ACH-000456	Thyroid Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000456	Thyroid Cancer	p.V600E (No)	CCLE	RAF265	0.7156
ACH-000477	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.2855
ACH-000477	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.3818
ACH-000550	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000550	Skin Cancer	p.V600E (No)	CCLE	RAF265	4.4041
ACH-000552	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	1.6781
ACH-000552	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	0.8196
ACH-000572	Skin Cancer	p.V600E (No)	CCLE	PLX4720	1.2867
ACH-000572	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.5653
ACH-000579	Skin Cancer	p.V600E (No)	CCLE	PLX4720	1.0641
ACH-000579	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.7168
ACH-000580	Skin Cancer	p.V600E (No)	CCLE	PLX4720	2.207
ACH-000580	Skin Cancer	p.V600E (No)	CCLE	RAF265	8
ACH-000582	Skin Cancer	p.V600E (No)	CCLE	PLX4720	4.0397
ACH-000614	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.7706
ACH-000614	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.6658
ACH-000640	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000640	Skin Cancer	p.V600E (No)	CCLE	RAF265	8
ACH-000650	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.9044
ACH-000650	Skin Cancer	p.V600E (No)	CCLE	RAF265	1.1985
ACH-000661	Skin Cancer	p.V600E (No)	CCLE	PLX4720	1.2264
ACH-000661	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.2069
ACH-000730	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.3691
ACH-000730	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.5234
ACH-000750	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000750	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.7089
ACH-000765	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.5112
ACH-000765	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.367
ACH-000788	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000788	Skin Cancer	p.V600E (No)	CCLE	RAF265	5.511
ACH-000799	Skin Cancer	p.V600E (No)	CCLE	PLX4720	7.2646
ACH-000799	Skin Cancer	p.V600E (No)	CCLE	RAF265	8
ACH-000805	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.5542
ACH-000805	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.6644
ACH-000814	Skin Cancer	p.V600E (No)	CCLE	PLX4720	2.1028
ACH-000814	Skin Cancer	p.V600E (No)	CCLE	RAF265	3.4481
ACH-000822	Skin Cancer	p.V600E (No)	CCLE	PLX4720	5.1545
ACH-000822	Skin Cancer	p.V600E (No)	CCLE	RAF265	6.2842
ACH-000827	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000827	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.838
ACH-000835	Sarcoma	p.V600E (No)	CCLE	PLX4720	5.2712
ACH-000835	Sarcoma	p.V600E (No)	CCLE	RAF265	0.3259
ACH-000863	Brain Cancer	p.V600E (No)	CCLE	PLX4720	2.6529
ACH-000863	Brain Cancer	p.V600E (No)	CCLE	RAF265	0.2865
ACH-000884	Skin Cancer	p.V600E (No)	CCLE	PLX4720	2.3128
ACH-000884	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.9112
ACH-000899	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.2041
ACH-000899	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.3115
ACH-000906	Ovarian Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000906	Ovarian Cancer	p.V600E (No)	CCLE	RAF265	1.1061
ACH-000943	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000943	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	1.5326
ACH-000985	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	0.9253
ACH-000985	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	1.9028
ACH-001039	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	0.3942
ACH-001039	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	0.6063
ACH-001239	Skin Cancer	p.V600E (No)	CCLE	PLX4720	1.5787
ACH-001239	Skin Cancer	p.V600E (No)	CCLE	RAF265	1.2205
ACH-001306	Thyroid Cancer	p.V600E (No)	CCLE	PLX4720	5.3134
ACH-001306	Thyroid Cancer	p.V600E (No)	CCLE	RAF265	1.0202
ACH-001307	Thyroid Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-001307	Thyroid Cancer	p.V600E (No)	CCLE	RAF265	1.4163
ACH-000656	Lymphoma	p.599_599T>TT (No)	CCLE	PLX4720	8
ACH-000656	Lymphoma	p.599_599T>TT (No)	CCLE	RAF265	2.264
ACH-000956	Prostate Cancer	p.L597R (No)	CCLE	PLX4720	8
ACH-000956	Prostate Cancer	p.L597R (No)	CCLE	RAF265	5.3659
ACH-000841	Lung Cancer	p.L597V (No)	CCLE	PLX4720	5.2114
ACH-000841	Lung Cancer	p.L597V (No)	CCLE	RAF265	2.6685
ACH-000801	Skin Cancer	p.N581K (No)	CCLE	PLX4720	8
ACH-000801	Skin Cancer	p.N581K (No)	CCLE	RAF265	8
ACH-000963	Colon/Colorectal Cancer	p.R506G (No)	CCLE	PLX4720	8
ACH-000963	Colon/Colorectal Cancer	p.R506G (No)	CCLE	RAF265	8
ACH-000535	Pancreatic Cancer	p.487_492VTAPTP>A (No)	CCLE	PLX4720	3.0007
ACH-000291	Ovarian Cancer	p.NVTAP486del (No)	CCLE	PLX4720	8
ACH-000291	Ovarian Cancer	p.NVTAP486del (No)	CCLE	RAF265	1.3413
ACH-000687	Lymphoma	p.L485W (No)	CCLE	PLX4720	8
ACH-000687	Lymphoma	p.L485W (No)	CCLE	RAF265	0.2085
ACH-000448	Lung Cancer	p.G466V (No)	CCLE	PLX4720	8
ACH-000448	Lung Cancer	p.G466V (No)	CCLE	RAF265	0.4364
ACH-000826	Lung Cancer	p.G466V (No)	CCLE	PLX4720	5.936
ACH-000542	Ovarian Cancer	p.G464E (No)	CCLE	RAF265	0.3171
ACH-000946	Endometrial/Uterine Cancer	p.P403fs (Yes)	CCLE	PLX4720	8
ACH-000946	Endometrial/Uterine Cancer	p.P403fs (Yes)	CCLE	RAF265	0.6019
ACH-000961	Endometrial/Uterine Cancer	p.P403fs (Yes)	CCLE	PLX4720	8
ACH-000962	Ovarian Cancer	p.P403fs (Yes)	CCLE	PLX4720	8
ACH-000962	Ovarian Cancer	p.P403fs (Yes)	CCLE	RAF265	3.6721
ACH-000965	Endometrial/Uterine Cancer	p.P403fs (Yes)	CCLE	PLX4720	8
ACH-000965	Endometrial/Uterine Cancer	p.P403fs (Yes)	CCLE	RAF265	0.2966
ACH-001145	Ovarian Cancer	p.P403fs (Yes)	CCLE	PLX4720	8
ACH-001145	Ovarian Cancer	p.P403fs (Yes)	CCLE	RAF265	3.0296
ACH-000932	Gastric Cancer	p.A400V (Yes)	CCLE	PLX4720	8
ACH-000932	Gastric Cancer	p.A400V (Yes)	CCLE	RAF265	1.6186
ACH-000893	Lung Cancer	p.E375D (No)	CCLE	PLX4720	8
ACH-000893	Lung Cancer	p.E375D (No)	CCLE	RAF265	8
ACH-000828	Breast Cancer	p.I326T (No)	CCLE	PLX4720	8
ACH-000828	Breast Cancer	p.I326T (No)	CCLE	RAF265	3.5978
ACH-000372	Leukemia	p.I326V (No)	CCLE	PLX4720	8
ACH-000372	Leukemia	p.I326V (No)	CCLE	RAF265	1.3275
ACH-000647	Esophageal Cancer	p.I326V (No)	CCLE	PLX4720	8
ACH-000693	Esophageal Cancer	p.I326V (No)	CCLE	PLX4720	8
ACH-000813	Lung Cancer	p.I326V (No)	CCLE	PLX4720	8
ACH-000813	Lung Cancer	p.I326V (No)	CCLE	RAF265	2.2039
ACH-000978	Endometrial/Uterine Cancer	p.I326V (No)	CCLE	PLX4720	8
ACH-000978	Endometrial/Uterine Cancer	p.I326V (No)	CCLE	RAF265	8
ACH-000810	Skin Cancer	p.D287H (No)	CCLE	PLX4720	8
ACH-000810	Skin Cancer	p.D287H (No)	CCLE	RAF265	1.2007
ACH-000810	Skin Cancer	p.E275K (No)	CCLE	PLX4720	8
ACH-000810	Skin Cancer	p.E275K (No)	CCLE	RAF265	1.2007
ACH-000963	Colon/Colorectal Cancer	p.S273N (No)	CCLE	PLX4720	8
ACH-000963	Colon/Colorectal Cancer	p.S273N (No)	CCLE	RAF265	8
ACH-000657	Ovarian Cancer	p.V226M (No)	CCLE	PLX4720	8
ACH-000657	Ovarian Cancer	p.V226M (No)	CCLE	RAF265	1.2503
ACH-000750	Skin Cancer	p.I208V (No)	CCLE	PLX4720	8
ACH-000750	Skin Cancer	p.I208V (No)	CCLE	RAF265	2.7089
ACH-000007	Colon/Colorectal Cancer	p.E204V (No)	CCLE	PLX4720	8
ACH-000007	Colon/Colorectal Cancer	p.E204V (No)	CCLE	RAF265	1.0833
ACH-000007	Colon/Colorectal Cancer	p.E204L (No)	CCLE	PLX4720	8
ACH-000007	Colon/Colorectal Cancer	p.E204L (No)	CCLE	RAF265	1.0833
ACH-000007	Colon/Colorectal Cancer	p.E204* (No)	CCLE	PLX4720	8
ACH-000007	Colon/Colorectal Cancer	p.E204* (No)	CCLE	RAF265	1.0833
ACH-000552	Colon/Colorectal Cancer	p.T119S (No)	CCLE	PLX4720	1.6781
ACH-000552	Colon/Colorectal Cancer	p.T119S (No)	CCLE	RAF265	0.8196
ACH-000876	Breast Cancer	p.P74A (No)	CCLE	PLX4720	8
ACH-000876	Breast Cancer	p.P74A (No)	CCLE	RAF265	1.7842
ACH-000573	Breast Cancer	p.GAGA30del (No)	CCLE	PLX4720	8
ACH-000573	Breast Cancer	p.GAGA30del (No)	CCLE	RAF265	2.5681
ACH-000581	Gastric Cancer	p.GAGA30del (No)	CCLE	PLX4720	8
ACH-000581	Gastric Cancer	p.GAGA30del (No)	CCLE	RAF265	0.7355
ACH-000588	Myeloma	p.D22N (No)	CCLE	PLX4720	8
ACH-000588	Myeloma	p.D22N (No)	CCLE	RAF265	8
ACH-000983	Leukemia	p.D22N (No)	CCLE	PLX4720	8
ACH-000983	Leukemia	p.D22N (No)	CCLE	RAF265	1.4428
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	HG6-64-1	0.784
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	PLX-4720	16.2594
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	PLX-4720	100.3989
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	Dabrafenib	82.7468
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	RAF_9304	16.5565
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	PLX-4720	117.36
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	Dabrafenib	57.308
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.0182
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.9741
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.5513
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.8656
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.4113
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0157
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.3509
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.1975
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0418
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	4.2515
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	21.6852
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	107.8543
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	19.3464
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	4.0953
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	41.9749
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	10.7756
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.8358
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.3666
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.418
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6834
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0128
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.4653
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.0703
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0312
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	HG6-64-1	2.6196
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	PLX-4720	11.7575
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	SB590885	26.6515
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	PLX-4720	21.026
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	Dabrafenib	17.6554
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	RAF_9304	9.646
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	0.4556
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	0.1948
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	0.1844
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	2.8929
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	1.827
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	1.8882
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	0.9285
SIDM00081	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	17.8392
SIDM00081	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.7996
SIDM00081	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.745
SIDM00081	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0414
SIDM00081	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.1934
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	23.4209
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.3144
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	1.1052
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.2105
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0228
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.4072
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	0.3952
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	3.1222
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	6.6318
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	6.8551
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.3819
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	2.243
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	18.492
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	5.8485
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.063
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	4.2356
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.5555
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	1.0791
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.2755
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0352
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.0645
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	5.8655
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.9654
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	HG6-64-1	2.1006
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	PLX-4720	24.9523
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	SB590885	41.7999
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	PLX-4720	14.2852
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	Dabrafenib	3.048
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	RAF_9304	10.4101
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	PLX-4720	29.876
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	Dabrafenib	28.237
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.123
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	9.5257
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	26.0896
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	17.6452
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	23.313
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	54.226
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.7478
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	5.4418
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	12.8241
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	32.6095
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	6.0803
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	5.6203
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	16.209
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	20.102
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	AZ628	2.1021
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	19.2154
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	11.1863
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	20.4888
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	6.7105
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	0.0816
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	0.6322
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	8.8807
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	2.5883
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	AZ628	2.1021
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	HG6-64-1	19.2154
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	PLX-4720	11.1863
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	SB590885	20.4888
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	PLX-4720	6.7105
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	Dabrafenib	0.0816
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	RAF_9304	0.6322
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	PLX-4720	8.8807
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	Dabrafenib	2.5883
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.4911
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	33.3135
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.8179
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	1.6525
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	6.6069
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0437
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	3.7015
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	13.689
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.5087
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	HG6-64-1	1.4481
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	PLX-4720	135.7882
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	SB590885	18.3599
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	PLX-4720	172.9987
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	Dabrafenib	25.7373
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	RAF_9304	5.0645
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	PLX-4720	266.66
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	Dabrafenib	74.817
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.7429
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	90.583
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	2.6462
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6485
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0242
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.1738
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	8.86
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0691
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	AZ628	13.5498
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	HG6-64-1	71.8037
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	PLX-4720	7.4528
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	SB590885	12.2105
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	PLX-4720	21.3523
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	Dabrafenib	3.4676
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	RAF_9304	4.0747
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	PLX-4720	3.2582
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	Dabrafenib	0.7355
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.0407
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.424
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.4653
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.7453
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.8377
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.065
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.6961
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.3076
SIDM00337	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.4113
SIDM00337	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.0916
SIDM00337	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6506
SIDM00337	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0183
SIDM00337	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.1851
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	2.2277
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	5.4267
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	3.2504
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.9954
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0409
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.5765
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	AZ628	0.6784
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	HG6-64-1	13.7444
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	PLX-4720	239.1703
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	SB590885	71.3856
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	PLX-4720	132.5968
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	Dabrafenib	80.713
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	RAF_9304	2.2841
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	PLX-4720	136.47
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	Dabrafenib	69.152
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.0482
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.235
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.716
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.6535
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	6.9841
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.1098
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	4.3918
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.0444
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (Yes)	GDSC	PLX-4720	12.5075
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (Yes)	GDSC	SB590885	25.3313
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (Yes)	GDSC	PLX-4720	16.1451
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (Yes)	GDSC	Dabrafenib	1.7787
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (Yes)	GDSC	RAF_9304	0.1572
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (Yes)	GDSC	PLX-4720	11.655
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (Yes)	GDSC	Dabrafenib	7.2347
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	4.0959
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.3271
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.1691
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.8412
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0223
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.3941
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.716
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0291
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	AZ628	0.0612
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	2.3707
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	45.6741
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	7.5353
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	28.6275
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	1.7649
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	1.0174
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	18.61
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	4.2239
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.4292
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	9.0433
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.2592
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0785
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.8168
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	4.8807
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	1.4474
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.031
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.815
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	7.8042
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	4.34
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.438
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.1077
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.3563
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	2.766
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	5.5788
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	5.252
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	1.786
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	0.5692
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	47.052
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	0.1633
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	19.3586
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	29.6014
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	13.5538
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	4.4819
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	6.2087
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	21.224
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	14.985
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	AZ628	47.4424
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	HG6-64-1	1.3276
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	PLX-4720	14.6807
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	SB590885	60.1877
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	PLX-4720	9.0501
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	Dabrafenib	0.3084
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	RAF_9304	8.155
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	2.2096
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	4.8529
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	2.515
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	4.163
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.1024
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.4877
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	AZ628	0.111
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	1.4595
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	0.9686
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	1.8922
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.0185
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	0.3929
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	3.3546
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.2933
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.7356
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.2481
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.0847
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.201
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0111
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.0885
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6414
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0346
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	HG6-64-1	0.4194
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	36.8996
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	SB590885	10.9472
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	43.6899
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	3.2771
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	RAF_9304	6.9736
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	33.427
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	13.141
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	2.2766
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.8579
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.4844
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.681
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.4335
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	3.0612
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	0.4977
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	6.8051
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	4.5796
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	5.8358
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.0588
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	1.6847
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	10.508
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	6.4848
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.7143
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.3347
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.0775
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.3479
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.01
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.1192
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.4551
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	4.1969
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	27.9632
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	46.1024
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	60.9245
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	29.5401
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	7.6081
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	45.522
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	7.3583
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	AZ628	12.7473
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	HG6-64-1	2.8103
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	44.5673
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	SB590885	71.5953
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	174.065
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	Dabrafenib	178.0424
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	RAF_9304	26.29
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	15.929
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	Dabrafenib	6.1246
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V600E (No)	GDSC	AZ628	0.0193
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V600E (No)	GDSC	HG6-64-1	0.8979
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (Yes)	GDSC	AZ628	7.8207
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (Yes)	GDSC	HG6-64-1	2.2575
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (Yes)	GDSC	PLX-4720	33.6635
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (Yes)	GDSC	SB590885	63.0315
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (Yes)	GDSC	PLX-4720	52.979
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (Yes)	GDSC	Dabrafenib	34.8313
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (Yes)	GDSC	RAF_9304	8.2806
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (Yes)	GDSC	PLX-4720	23.185
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (Yes)	GDSC	Dabrafenib	136.69
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	AZ628	0.1194
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	HG6-64-1	0.5302
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	5.1001
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	SB590885	26.7941
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	5.3141
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	0.0952
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	RAF_9304	1.9808
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	31.912
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	49.59
SIDM00220	OV\|ovary	p.P403fs*8 (Yes)	GDSC	HG6-64-1	0.958
SIDM00220	OV\|ovary	p.P403fs*8 (Yes)	GDSC	PLX-4720	34.7171
SIDM00220	OV\|ovary	p.P403fs*8 (Yes)	GDSC	SB590885	34.8119
SIDM00220	OV\|ovary	p.P403fs*8 (Yes)	GDSC	PLX-4720	50.9251
SIDM00220	OV\|ovary	p.P403fs*8 (Yes)	GDSC	Dabrafenib	8.004
SIDM00220	OV\|ovary	p.P403fs*8 (Yes)	GDSC	RAF_9304	9.9127
SIDM00220	OV\|ovary	p.P403fs*8 (Yes)	GDSC	Dabrafenib	19.044
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	AZ628	0.1111
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	1.046
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	7.6466
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	9.4412
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	7.7144
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	3.7886
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	2.6704
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	7.57
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	8.4019
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	10.3276
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.9015
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.7516
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	15.0547
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	2.0225
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	5.4464
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	3.3405
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	27.6796
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	6.6239
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	2.3761
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	4.0624
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.1069
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	2.9833
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.0214
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.3301
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.8578
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.4424
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.6006
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.1008
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.7017
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.0559
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0451
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.3397
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	10.4879
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	5.9803
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	19.7206
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	2.5556
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	8.1401
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	26.799
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	1.8268
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	29.2379
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	18.8072
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	81.458
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	6.4378
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	9.2259
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	104.73
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	19.445
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.073
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.4072
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.713
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.4018
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0093
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.4251
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	AZ628	22.0213
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	HG6-64-1	34.267
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	PLX-4720	97.014
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	SB590885	56.5869
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	PLX-4720	17.5982
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	Dabrafenib	11.2326
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	RAF_9304	4.2278
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	PLX-4720	659.27
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	Dabrafenib	241.06
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	7.2849
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	0.725
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	1.5055
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	1.7193
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.0343
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	0.4244
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	8.6722
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	1.5199
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (Yes)	GDSC	AZ628	1.5027
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (Yes)	GDSC	HG6-64-1	1.5217
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (Yes)	GDSC	PLX-4720	152.3118
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (Yes)	GDSC	SB590885	47.7205
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (Yes)	GDSC	PLX-4720	147.618
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (Yes)	GDSC	Dabrafenib	32.667
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (Yes)	GDSC	RAF_9304	78.5966
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (Yes)	GDSC	PLX-4720	195.01
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (Yes)	GDSC	Dabrafenib	19.04
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.1752
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.7926
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	9.7138
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.4809
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.1633
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.7912
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	2.7207
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	3.1424
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.1588
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.8132
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	2.6247
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.1281
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0515
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.4978
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	9.836
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	3.7246
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	AZ628	0.6392
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	HG6-64-1	7.3787
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	PLX-4720	6.7394
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	SB590885	6.333
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	PLX-4720	2.4495
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	Dabrafenib	0.0554
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	RAF_9304	0.5014
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	PLX-4720	18.975
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	Dabrafenib	1.4074
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	HG6-64-1	0.3982
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	4.8813
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	SB590885	6.1877
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	5.925
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	0.1105
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	RAF_9304	3.5103
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	3.5991
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	14.611
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	HG6-64-1	0.7113
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	4.5807
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	SB590885	3.6674
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	9.4056
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	Dabrafenib	0.2694
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	RAF_9304	2.0031
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	24.347
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	Dabrafenib	6.4612
SIDM00319	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	9.5978
SIDM00319	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	92.1974
SIDM00319	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	37.7428
SIDM00319	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	132.8688
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	2.4177
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	4.7456
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	4.4704
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	6.9569
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	1.3468
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	7.1667
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	1.1932
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (Yes)	GDSC	AZ628	7.6703
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (Yes)	GDSC	HG6-64-1	2.5897
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (Yes)	GDSC	PLX-4720	14.397
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (Yes)	GDSC	SB590885	32.9239
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (Yes)	GDSC	PLX-4720	89.2636
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (Yes)	GDSC	Dabrafenib	6.0411
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (Yes)	GDSC	RAF_9304	5.663
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (Yes)	GDSC	PLX-4720	13.009
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (Yes)	GDSC	Dabrafenib	3.0189
SIDM00663	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	2.7738
SIDM00663	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.3063
SIDM00663	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	3.5247
SIDM00663	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	5.0274
SIDM00663	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.657
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	2.6125
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	9.7105
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	40.8578
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	38.8484
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	4.9847
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	19.631
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	86.343
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	HG6-64-1	61.9214
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	PLX-4720	167.3606
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	SB590885	91.3112
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	RAF_9304	8.4746
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	PLX-4720	34.291
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	Dabrafenib	41.914
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	HG6-64-1	0.3475
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	PLX-4720	9.3928
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	SB590885	12.1057
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	PLX-4720	8.9339
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	RAF_9304	4.5987
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	PLX-4720	17.166
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	Dabrafenib	60.518
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	HG6-64-1	0.9491
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	PLX-4720	20.0525
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	SB590885	47.0321
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	PLX-4720	46.5981
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	Dabrafenib	17.3698
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	RAF_9304	18.4974
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	PLX-4720	28.557
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	Dabrafenib	45.968
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.4774
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.654
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	11.4967
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	8.7089
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	11.0183
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.4923
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	4.3033
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	14.364
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	33.301
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	0.3248
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	5.7641
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	22.8943
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	9.3493
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.21
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	3.4172
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	24.878
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	8.1065
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	33.9182
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.9826
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	1.8369
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.8845
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.2461
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.3552
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	18.338
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	PLX-4720	114.7274
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	SB590885	37.3331
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	PLX-4720	187.5677
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	Dabrafenib	14.6545
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	RAF_9304	27.2961
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	PLX-4720	232.94
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	Dabrafenib	3.7526
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	79.6307
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.2274
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.1377
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.0683
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0128
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.3932
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.3399
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0431
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.4918
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.214
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.1252
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.8329
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.029
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.5179
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.7973
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	11.1957
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	7.681
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	14.267
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	3.8498
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	16.327
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	7.9645
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	HG6-64-1	0.7973
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	PLX-4720	11.1957
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	SB590885	7.681
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	PLX-4720	14.267
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	RAF_9304	3.8498
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	PLX-4720	16.327
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	Dabrafenib	7.9645
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	PLX-4720	51.9587
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	PLX-4720	155.6419
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	Dabrafenib	2.9927
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	RAF_9304	0.1818
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	PLX-4720	21.511
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	Dabrafenib	13.473
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.1153
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	76.4739
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	44.4897
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6548
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0317
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.5022
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6024
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0438
SIDM01104	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	41.0719
SIDM01104	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	143.8874
SIDM01104	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	44.0069
SIDM01104	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	69.8297
SIDM01104	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	17.3207
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	0.6707
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	1.7545
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	12.7808
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	1.8853
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.0623
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	0.281
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	4.1829
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	3.9789
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	AZ628	0.0335
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	HG6-64-1	1.3842
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	PLX-4720	0.2116
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	SB590885	0.1301
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	PLX-4720	0.9465
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	Dabrafenib	0.0111
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	RAF_9304	0.2852
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	PLX-4720	0.3942
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	Dabrafenib	0.0062
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.8374
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.1263
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	5.276
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.2087
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0412
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.7572
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.0651
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.4851
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.7489
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.1371
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.286
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6227
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0427
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.2362
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.1234
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0986
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	PLX-4720	23.5475
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	SB590885	3.6874
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	PLX-4720	28.9959
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	Dabrafenib	1.0539
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	RAF_9304	1.027
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	PLX-4720	269.4
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	Dabrafenib	13.331
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	HG6-64-1	0.4144
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	PLX-4720	128.9641
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	SB590885	58.8035
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	PLX-4720	80.6032
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	Dabrafenib	16.7904
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	RAF_9304	3.2104
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	PLX-4720	172.85
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	Dabrafenib	84.017
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	AZ628	5.616
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	HG6-64-1	15.5807
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	PLX-4720	83.1165
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	SB590885	35.7633
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	PLX-4720	124.3484
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	Dabrafenib	121.7009
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	RAF_9304	4.9625
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	PLX-4720	366.19
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	Dabrafenib	312.91
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	AZ628	201.7796
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	HG6-64-1	44.2281
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	SB590885	5.4412
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	PLX-4720	202.1652
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	Dabrafenib	277.3225
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	RAF_9304	52.7835
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	Dabrafenib	28.631
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	HG6-64-1	2.4582
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	PLX-4720	40.8215
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	SB590885	53.7745
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	PLX-4720	100.7327
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	Dabrafenib	38.4906
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	RAF_9304	5.4494
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	PLX-4720	40.399
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	Dabrafenib	49.801
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	HG6-64-1	1.4679
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	PLX-4720	35.2742
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	SB590885	17.3394
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	PLX-4720	217.5603
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	Dabrafenib	207.0116
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	RAF_9304	7.5345
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	PLX-4720	413.5
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	Dabrafenib	257.61
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	HG6-64-1	5.9278
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	PLX-4720	165.7139
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	SB590885	32.1117
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	PLX-4720	70.6978
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	Dabrafenib	33.0926
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	RAF_9304	14.3405
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	PLX-4720	173.1
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	Dabrafenib	428.57
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	HG6-64-1	4.4843
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	PLX-4720	30.3453
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	SB590885	5.2656
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	PLX-4720	100.8936
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	Dabrafenib	69.1367
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	RAF_9304	10.8244
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	PLX-4720	24.619
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	Dabrafenib	23.109
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	HG6-64-1	0.7148
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	PLX-4720	125.5491
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	SB590885	62.7746
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	PLX-4720	161.0492
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	Dabrafenib	114.1437
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	RAF_9304	6.5207
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	PLX-4720	18.9574
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	SB590885	218.9344
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	PLX-4720	172.243
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	Dabrafenib	51.2182
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	RAF_9304	14.3193
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	Dabrafenib	20.359
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	AZ628	0.6784
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	HG6-64-1	13.7444
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	PLX-4720	239.1703
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	SB590885	71.3856
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	PLX-4720	132.5968
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	Dabrafenib	80.713
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	RAF_9304	2.2841
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	PLX-4720	136.47
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	Dabrafenib	69.152
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	PLX-4720	886.8253
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	SB590885	437.8463
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	PLX-4720	471.7159
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	Dabrafenib	226.941
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	RAF_9304	184.3223
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	PLX-4720	214.19
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	Dabrafenib	1495
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	PLX-4720	188.8846
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	SB590885	85.2709
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	PLX-4720	134.821
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	Dabrafenib	15.5531
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	RAF_9304	4.8864
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	PLX-4720	269.92
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	Dabrafenib	91.258
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	HG6-64-1	0.958
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	PLX-4720	34.7171
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	SB590885	34.8119
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	PLX-4720	50.9251
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	Dabrafenib	8.004
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	RAF_9304	9.9127
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	Dabrafenib	19.044
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	HG6-64-1	0.3902
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	26.3838
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	SB590885	28.6295
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	44.5205
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	Dabrafenib	101.4116
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	RAF_9304	4.9368
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	56.092
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	Dabrafenib	135.91
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	HG6-64-1	2.595
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	PLX-4720	96.4523
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	SB590885	71.3977
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	PLX-4720	125.1844
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	RAF_9304	4.0883
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	PLX-4720	69.564
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	Dabrafenib	176.3
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	HG6-64-1	0.6561
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	PLX-4720	47.872
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	SB590885	73.0867
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	PLX-4720	22.7722
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	Dabrafenib	35.4235
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	RAF_9304	4.8508
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	PLX-4720	34.825
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	Dabrafenib	59.149
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	HG6-64-1	113.1124
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	PLX-4720	161.095
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	SB590885	183.4434
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	PLX-4720	219.324
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	Dabrafenib	219.324
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	RAF_9304	50.3157
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	PLX-4720	137.21
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	Dabrafenib	468.69
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	AZ628	6.8003
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	HG6-64-1	12.148
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	100.9473
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	SB590885	107.1339
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	56.948
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	Dabrafenib	21.2137
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	RAF_9304	10.0795
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	153.48
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	Dabrafenib	301.82
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	HG6-64-1	0.7143
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	PLX-4720	0.3347
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	SB590885	0.0775
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	PLX-4720	0.3479
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	Dabrafenib	0.01
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	RAF_9304	0.1192
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	PLX-4720	0.4551
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	HG6-64-1	1.1856
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	PLX-4720	29.9772
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	SB590885	9.8517
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	PLX-4720	57.9452
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	Dabrafenib	19.1118
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	RAF_9304	6.1975
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	PLX-4720	297.21
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	Dabrafenib	218.02
SIDM00217	COREAD\|large_intestine	p.V120I (No)	GDSC	PLX-4720	173.5516
SIDM00217	COREAD\|large_intestine	p.V120I (No)	GDSC	Dabrafenib	88.5347
SIDM00217	COREAD\|large_intestine	p.V120I (No)	GDSC	RAF_9304	59.291
SIDM00217	COREAD\|large_intestine	p.V120I (No)	GDSC	PLX-4720	334.77
SIDM00217	COREAD\|large_intestine	p.V120I (No)	GDSC	Dabrafenib	175.03
SIDM00217	COREAD\|large_intestine	p.S76P (No)	GDSC	PLX-4720	173.5516
SIDM00217	COREAD\|large_intestine	p.S76P (No)	GDSC	Dabrafenib	88.5347
SIDM00217	COREAD\|large_intestine	p.S76P (No)	GDSC	RAF_9304	59.291
SIDM00217	COREAD\|large_intestine	p.S76P (No)	GDSC	PLX-4720	334.77
SIDM00217	COREAD\|large_intestine	p.S76P (No)	GDSC	Dabrafenib	175.03
SIDM00889	CESC\|cervix	p.A115V (No)	GDSC	HG6-64-1	0.8731
SIDM00889	CESC\|cervix	p.A115V (No)	GDSC	PLX-4720	63.3044
SIDM00889	CESC\|cervix	p.A115V (No)	GDSC	SB590885	75.8924
SIDM00889	CESC\|cervix	p.A115V (No)	GDSC	PLX-4720	41.9715
SIDM00889	CESC\|cervix	p.A115V (No)	GDSC	Dabrafenib	17.5007
SIDM00889	CESC\|cervix	p.A115V (No)	GDSC	RAF_9304	8.3295
SIDM00889	CESC\|cervix	p.A115V (No)	GDSC	PLX-4720	42.328
SIDM00889	CESC\|cervix	p.A115V (No)	GDSC	Dabrafenib	80.283
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	AZ628	1.5027
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	HG6-64-1	1.5217
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	PLX-4720	152.3118
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	SB590885	47.7205
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	PLX-4720	147.618
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	Dabrafenib	32.667
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	RAF_9304	78.5966
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	PLX-4720	195.01
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	Dabrafenib	19.04
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	HG6-64-1	2.8556
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	PLX-4720	129.431
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	SB590885	67.683
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	PLX-4720	214.1023
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	Dabrafenib	122.2077
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	RAF_9304	9.3137
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	PLX-4720	142.36
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	Dabrafenib	353.77
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	HG6-64-1	6.8422
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	PLX-4720	95.7786
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	SB590885	1.8165
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	PLX-4720	58.1484
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	Dabrafenib	0.0264
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	RAF_9304	0.5262
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	PLX-4720	141.51
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	Dabrafenib	0.7779
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	AZ628	55.9174
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	HG6-64-1	40.8254
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	PLX-4720	60.7242
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	SB590885	93.9636
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	PLX-4720	86.4617
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	Dabrafenib	110.6714
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	RAF_9304	84.0123
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	PLX-4720	759.01
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	AZ628	1.1505
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	HG6-64-1	2.3141
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	PLX-4720	66.5647
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	SB590885	27.3066
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	PLX-4720	33.2664
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	Dabrafenib	65.027
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	RAF_9304	4.539
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	PLX-4720	46.626
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	Dabrafenib	40.909
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	HG6-64-1	11.5239
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	PLX-4720	178.9034
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	SB590885	72.958
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	PLX-4720	121.4102
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	Dabrafenib	31.2908
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	RAF_9304	6.5261
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	PLX-4720	102.35
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	Dabrafenib	277.09
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	AZ628	3.1424
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	HG6-64-1	1.1588
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	PLX-4720	2.8132
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	SB590885	2.6247
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	PLX-4720	3.1281
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	Dabrafenib	0.0515
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	RAF_9304	0.4978
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	PLX-4720	9.836
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	Dabrafenib	3.7246
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	HG6-64-1	5.1355
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	PLX-4720	140.6543
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	SB590885	7.9844
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	PLX-4720	143.2376
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	Dabrafenib	138.0282
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	RAF_9304	9.7863
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	PLX-4720	117.58
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	Dabrafenib	260.62
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	HG6-64-1	5.1355
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	PLX-4720	140.6543
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	SB590885	7.9844
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	PLX-4720	143.2376
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	Dabrafenib	138.0282
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	RAF_9304	9.7863
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	PLX-4720	117.58
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	Dabrafenib	260.62
SIDM00392	SKCM\|melanoma	p.D287H (No)	GDSC	HG6-64-1	2.1878
SIDM00392	SKCM\|melanoma	p.D287H (No)	GDSC	PLX-4720	33.9119
SIDM00392	SKCM\|melanoma	p.D287H (No)	GDSC	PLX-4720	106.5127
SIDM00392	SKCM\|melanoma	p.D287H (No)	GDSC	Dabrafenib	25.2998
SIDM00392	SKCM\|melanoma	p.D287H (No)	GDSC	RAF_9304	1.1505
SIDM00392	SKCM\|melanoma	p.E275K (No)	GDSC	HG6-64-1	2.1878
SIDM00392	SKCM\|melanoma	p.E275K (No)	GDSC	PLX-4720	33.9119
SIDM00392	SKCM\|melanoma	p.E275K (No)	GDSC	PLX-4720	106.5127
SIDM00392	SKCM\|melanoma	p.E275K (No)	GDSC	Dabrafenib	25.2998
SIDM00392	SKCM\|melanoma	p.E275K (No)	GDSC	RAF_9304	1.1505
SIDM00136	COREAD\|large_intestine	p.T119S (No)	GDSC	HG6-64-1	2.4177
SIDM00136	COREAD\|large_intestine	p.T119S (No)	GDSC	PLX-4720	4.7456
SIDM00136	COREAD\|large_intestine	p.T119S (No)	GDSC	SB590885	4.4704
SIDM00136	COREAD\|large_intestine	p.T119S (No)	GDSC	PLX-4720	6.9569
SIDM00136	COREAD\|large_intestine	p.T119S (No)	GDSC	RAF_9304	1.3468
SIDM00136	COREAD\|large_intestine	p.T119S (No)	GDSC	PLX-4720	7.1667
SIDM00136	COREAD\|large_intestine	p.T119S (No)	GDSC	Dabrafenib	1.1932
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	HG6-64-1	1.2179
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	PLX-4720	67.9463
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	SB590885	68.2782
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	PLX-4720	44.0458
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	Dabrafenib	5.9294
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	RAF_9304	4.9226
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	PLX-4720	330.3
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	Dabrafenib	35.497
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	HG6-64-1	2.2635
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	PLX-4720	83.0188
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	SB590885	74.948
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	PLX-4720	89.9396
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	Dabrafenib	31.3018
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	RAF_9304	24.7008
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	PLX-4720	38.82
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	Dabrafenib	108.7
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	AZ628	7.3299
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	HG6-64-1	2.3565
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	PLX-4720	7.3671
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	SB590885	5.8546
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	PLX-4720	24.5475
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	Dabrafenib	7.0761
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	RAF_9304	22.3291
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	PLX-4720	106.13
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	Dabrafenib	19.14
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	HG6-64-1	0.7938
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	PLX-4720	44.089
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	SB590885	41.2288
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	PLX-4720	89.9366
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	Dabrafenib	88.9832
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	RAF_9304	5.9598
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	PLX-4720	69.682
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	Dabrafenib	203.53
SIDM01146	STAD\|stomach	p.A400V (Yes)	GDSC	AZ628	0.4586
SIDM01146	STAD\|stomach	p.A400V (Yes)	GDSC	HG6-64-1	1.2271
SIDM01146	STAD\|stomach	p.A400V (Yes)	GDSC	PLX-4720	27.2982
SIDM01146	STAD\|stomach	p.A400V (Yes)	GDSC	SB590885	10.1108
SIDM01146	STAD\|stomach	p.A400V (Yes)	GDSC	PLX-4720	181.7476
SIDM01146	STAD\|stomach	p.A400V (Yes)	GDSC	Dabrafenib	48.7313
SIDM01146	STAD\|stomach	p.A400V (Yes)	GDSC	RAF_9304	9.7076
SIDM01146	STAD\|stomach	p.A400V (Yes)	GDSC	PLX-4720	147.53
SIDM01146	STAD\|stomach	p.A400V (Yes)	GDSC	Dabrafenib	116.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSATPPAS

Degron related mutations and impact score

Drug responses associated with BRAF mutations

All proteins holding degron of LSATPPAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15056	Serine/threonine-protein kinase B-raf	DEG_SCF_FBW7_1	398:405	LSATPPAS	FBXW7	0.9884	More...