DegronMD

Uniprot ID: P15056

Source protein: Serine/threonine-protein kinase B-raf

Source gene: BRAF

Class: DEG_SPOP_SBC_1

Location: 120:124

E3 ligase: SPOP

DEGRON score: 0.9734

ASA_SCORE: 84.84

COIL: 0.9294

CONS_SCORE: 0.2629

DSS_SCORE: 0.4226

HELIX: 0.0514

FCONS_SCORE: 0.9398

RIG_SCORE: 0.6471

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S113I	TCGA-44-3918	LUAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1389
p.S113I	DO23732	LUAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.S112C	TCGA-5L-AAT1	BRCA	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1111
p.S112C	DO219594	BRCA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1111
p.M117T	TCGA-B5-A3FA	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.25
p.M117T	DO52402	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.25
p.S129L	TCGA-G2-A2EL	BLCA	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1944
p.S129L	DO478	BLCA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.M117I	TCGA-TS-A7P8	MESO	TCGA	VTSSS	DEG_SPOP_SBC_1	0.25
p.S127R	DO229008	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.25
p.A115V	SIDM00889	Cervical Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.A115V	ACH-001333	Cervical Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.1944
p.A115V	C-33-A	cervix	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.T119S	SIDM00136	Colorectal Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.75
p.T119S	ACH-000552	Colon/Colorectal Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.75
p.T119S	HT-29	large_intestine	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.75
p.V120I	SIDM00217	Colorectal Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.7076
p.V120I	ACH-000999	Colon/Colorectal Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.7076
p.V120I	SNU-1040	large_intestine	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.7076

Drug responses associated with BRAF mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000962	Ovarian Cancer	p.A747V (No)	CCLE	PLX4720	8
ACH-000962	Ovarian Cancer	p.A747V (No)	CCLE	RAF265	3.6721
ACH-001145	Ovarian Cancer	p.A747V (No)	CCLE	PLX4720	8
ACH-001145	Ovarian Cancer	p.A747V (No)	CCLE	RAF265	3.0296
ACH-000995	Leukemia	p.A728V (No)	CCLE	PLX4720	3.7589
ACH-000995	Leukemia	p.A728V (No)	CCLE	RAF265	0.3566
ACH-000988	Endometrial/Uterine Cancer	p.S727G (No)	CCLE	PLX4720	8
ACH-000890	Lung Cancer	p.S683N (No)	CCLE	PLX4720	8
ACH-000890	Lung Cancer	p.S683N (No)	CCLE	RAF265	3.4915
ACH-000941	Endometrial/Uterine Cancer	p.R682Q (No)	CCLE	PLX4720	8
ACH-000941	Endometrial/Uterine Cancer	p.R682Q (No)	CCLE	RAF265	8
ACH-000954	Endometrial/Uterine Cancer	p.R682Q (No)	CCLE	PLX4720	8
ACH-000954	Endometrial/Uterine Cancer	p.R682Q (No)	CCLE	RAF265	2.657
ACH-000862	Bladder Cancer	p.M650I (No)	CCLE	PLX4720	8
ACH-000862	Bladder Cancer	p.M650I (No)	CCLE	RAF265	4.1045
ACH-000346	Leukemia	p.K601N (No)	CCLE	PLX4720	3.7271
ACH-000346	Leukemia	p.K601N (No)	CCLE	RAF265	0.13
ACH-000304	Skin Cancer	p.V600D (No)	CCLE	PLX4720	8
ACH-000304	Skin Cancer	p.V600D (No)	CCLE	RAF265	2.8096
ACH-001239	Skin Cancer	p.V600D (No)	CCLE	PLX4720	1.5787
ACH-001239	Skin Cancer	p.V600D (No)	CCLE	RAF265	1.2205
ACH-000014	Metastasis	p.V600E (No)	CCLE	PLX4720	8
ACH-000014	Metastasis	p.V600E (No)	CCLE	RAF265	2.9046
ACH-000052	Bone Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000052	Bone Cancer	p.V600E (No)	CCLE	RAF265	0.8097
ACH-000112	Leukemia	p.V600E (No)	CCLE	PLX4720	0.0336
ACH-000112	Leukemia	p.V600E (No)	CCLE	RAF265	0.1571
ACH-000219	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.2583
ACH-000219	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.6227
ACH-000236	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	2.2788
ACH-000236	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	0.2024
ACH-000253	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	0.6257
ACH-000253	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	0.4351
ACH-000304	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000304	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.8096
ACH-000322	Skin Cancer	p.V600E (No)	CCLE	PLX4720	1.3363
ACH-000322	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.3401
ACH-000348	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000348	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.4054
ACH-000361	Liver Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000361	Liver Cancer	p.V600E (No)	CCLE	RAF265	0.174
ACH-000404	Skin Cancer	p.V600E (No)	CCLE	PLX4720	2.1106
ACH-000404	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.7067
ACH-000425	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.2497
ACH-000425	Skin Cancer	p.V600E (No)	CCLE	RAF265	1.0647
ACH-000450	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.313
ACH-000450	Skin Cancer	p.V600E (No)	CCLE	RAF265	1.1835
ACH-000456	Thyroid Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000456	Thyroid Cancer	p.V600E (No)	CCLE	RAF265	0.7156
ACH-000477	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.2855
ACH-000477	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.3818
ACH-000550	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000550	Skin Cancer	p.V600E (No)	CCLE	RAF265	4.4041
ACH-000552	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	1.6781
ACH-000552	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	0.8196
ACH-000572	Skin Cancer	p.V600E (No)	CCLE	PLX4720	1.2867
ACH-000572	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.5653
ACH-000579	Skin Cancer	p.V600E (No)	CCLE	PLX4720	1.0641
ACH-000579	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.7168
ACH-000580	Skin Cancer	p.V600E (No)	CCLE	PLX4720	2.207
ACH-000580	Skin Cancer	p.V600E (No)	CCLE	RAF265	8
ACH-000582	Skin Cancer	p.V600E (No)	CCLE	PLX4720	4.0397
ACH-000614	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.7706
ACH-000614	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.6658
ACH-000640	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000640	Skin Cancer	p.V600E (No)	CCLE	RAF265	8
ACH-000650	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.9044
ACH-000650	Skin Cancer	p.V600E (No)	CCLE	RAF265	1.1985
ACH-000661	Skin Cancer	p.V600E (No)	CCLE	PLX4720	1.2264
ACH-000661	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.2069
ACH-000730	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.3691
ACH-000730	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.5234
ACH-000750	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000750	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.7089
ACH-000765	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.5112
ACH-000765	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.367
ACH-000788	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000788	Skin Cancer	p.V600E (No)	CCLE	RAF265	5.511
ACH-000799	Skin Cancer	p.V600E (No)	CCLE	PLX4720	7.2646
ACH-000799	Skin Cancer	p.V600E (No)	CCLE	RAF265	8
ACH-000805	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.5542
ACH-000805	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.6644
ACH-000814	Skin Cancer	p.V600E (No)	CCLE	PLX4720	2.1028
ACH-000814	Skin Cancer	p.V600E (No)	CCLE	RAF265	3.4481
ACH-000822	Skin Cancer	p.V600E (No)	CCLE	PLX4720	5.1545
ACH-000822	Skin Cancer	p.V600E (No)	CCLE	RAF265	6.2842
ACH-000827	Skin Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000827	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.838
ACH-000835	Sarcoma	p.V600E (No)	CCLE	PLX4720	5.2712
ACH-000835	Sarcoma	p.V600E (No)	CCLE	RAF265	0.3259
ACH-000863	Brain Cancer	p.V600E (No)	CCLE	PLX4720	2.6529
ACH-000863	Brain Cancer	p.V600E (No)	CCLE	RAF265	0.2865
ACH-000884	Skin Cancer	p.V600E (No)	CCLE	PLX4720	2.3128
ACH-000884	Skin Cancer	p.V600E (No)	CCLE	RAF265	2.9112
ACH-000899	Skin Cancer	p.V600E (No)	CCLE	PLX4720	0.2041
ACH-000899	Skin Cancer	p.V600E (No)	CCLE	RAF265	0.3115
ACH-000906	Ovarian Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000906	Ovarian Cancer	p.V600E (No)	CCLE	RAF265	1.1061
ACH-000943	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-000943	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	1.5326
ACH-000985	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	0.9253
ACH-000985	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	1.9028
ACH-001039	Colon/Colorectal Cancer	p.V600E (No)	CCLE	PLX4720	0.3942
ACH-001039	Colon/Colorectal Cancer	p.V600E (No)	CCLE	RAF265	0.6063
ACH-001239	Skin Cancer	p.V600E (No)	CCLE	PLX4720	1.5787
ACH-001239	Skin Cancer	p.V600E (No)	CCLE	RAF265	1.2205
ACH-001306	Thyroid Cancer	p.V600E (No)	CCLE	PLX4720	5.3134
ACH-001306	Thyroid Cancer	p.V600E (No)	CCLE	RAF265	1.0202
ACH-001307	Thyroid Cancer	p.V600E (No)	CCLE	PLX4720	8
ACH-001307	Thyroid Cancer	p.V600E (No)	CCLE	RAF265	1.4163
ACH-000656	Lymphoma	p.599_599T>TT (No)	CCLE	PLX4720	8
ACH-000656	Lymphoma	p.599_599T>TT (No)	CCLE	RAF265	2.264
ACH-000956	Prostate Cancer	p.L597R (No)	CCLE	PLX4720	8
ACH-000956	Prostate Cancer	p.L597R (No)	CCLE	RAF265	5.3659
ACH-000841	Lung Cancer	p.L597V (No)	CCLE	PLX4720	5.2114
ACH-000841	Lung Cancer	p.L597V (No)	CCLE	RAF265	2.6685
ACH-000801	Skin Cancer	p.N581K (No)	CCLE	PLX4720	8
ACH-000801	Skin Cancer	p.N581K (No)	CCLE	RAF265	8
ACH-000963	Colon/Colorectal Cancer	p.R506G (No)	CCLE	PLX4720	8
ACH-000963	Colon/Colorectal Cancer	p.R506G (No)	CCLE	RAF265	8
ACH-000535	Pancreatic Cancer	p.487_492VTAPTP>A (No)	CCLE	PLX4720	3.0007
ACH-000291	Ovarian Cancer	p.NVTAP486del (No)	CCLE	PLX4720	8
ACH-000291	Ovarian Cancer	p.NVTAP486del (No)	CCLE	RAF265	1.3413
ACH-000687	Lymphoma	p.L485W (No)	CCLE	PLX4720	8
ACH-000687	Lymphoma	p.L485W (No)	CCLE	RAF265	0.2085
ACH-000448	Lung Cancer	p.G466V (No)	CCLE	PLX4720	8
ACH-000448	Lung Cancer	p.G466V (No)	CCLE	RAF265	0.4364
ACH-000826	Lung Cancer	p.G466V (No)	CCLE	PLX4720	5.936
ACH-000542	Ovarian Cancer	p.G464E (No)	CCLE	RAF265	0.3171
ACH-000946	Endometrial/Uterine Cancer	p.P403fs (No)	CCLE	PLX4720	8
ACH-000946	Endometrial/Uterine Cancer	p.P403fs (No)	CCLE	RAF265	0.6019
ACH-000961	Endometrial/Uterine Cancer	p.P403fs (No)	CCLE	PLX4720	8
ACH-000962	Ovarian Cancer	p.P403fs (No)	CCLE	PLX4720	8
ACH-000962	Ovarian Cancer	p.P403fs (No)	CCLE	RAF265	3.6721
ACH-000965	Endometrial/Uterine Cancer	p.P403fs (No)	CCLE	PLX4720	8
ACH-000965	Endometrial/Uterine Cancer	p.P403fs (No)	CCLE	RAF265	0.2966
ACH-001145	Ovarian Cancer	p.P403fs (No)	CCLE	PLX4720	8
ACH-001145	Ovarian Cancer	p.P403fs (No)	CCLE	RAF265	3.0296
ACH-000932	Gastric Cancer	p.A400V (No)	CCLE	PLX4720	8
ACH-000932	Gastric Cancer	p.A400V (No)	CCLE	RAF265	1.6186
ACH-000893	Lung Cancer	p.E375D (No)	CCLE	PLX4720	8
ACH-000893	Lung Cancer	p.E375D (No)	CCLE	RAF265	8
ACH-000828	Breast Cancer	p.I326T (No)	CCLE	PLX4720	8
ACH-000828	Breast Cancer	p.I326T (No)	CCLE	RAF265	3.5978
ACH-000372	Leukemia	p.I326V (No)	CCLE	PLX4720	8
ACH-000372	Leukemia	p.I326V (No)	CCLE	RAF265	1.3275
ACH-000647	Esophageal Cancer	p.I326V (No)	CCLE	PLX4720	8
ACH-000693	Esophageal Cancer	p.I326V (No)	CCLE	PLX4720	8
ACH-000813	Lung Cancer	p.I326V (No)	CCLE	PLX4720	8
ACH-000813	Lung Cancer	p.I326V (No)	CCLE	RAF265	2.2039
ACH-000978	Endometrial/Uterine Cancer	p.I326V (No)	CCLE	PLX4720	8
ACH-000978	Endometrial/Uterine Cancer	p.I326V (No)	CCLE	RAF265	8
ACH-000810	Skin Cancer	p.D287H (No)	CCLE	PLX4720	8
ACH-000810	Skin Cancer	p.D287H (No)	CCLE	RAF265	1.2007
ACH-000810	Skin Cancer	p.E275K (No)	CCLE	PLX4720	8
ACH-000810	Skin Cancer	p.E275K (No)	CCLE	RAF265	1.2007
ACH-000963	Colon/Colorectal Cancer	p.S273N (No)	CCLE	PLX4720	8
ACH-000963	Colon/Colorectal Cancer	p.S273N (No)	CCLE	RAF265	8
ACH-000657	Ovarian Cancer	p.V226M (No)	CCLE	PLX4720	8
ACH-000657	Ovarian Cancer	p.V226M (No)	CCLE	RAF265	1.2503
ACH-000750	Skin Cancer	p.I208V (No)	CCLE	PLX4720	8
ACH-000750	Skin Cancer	p.I208V (No)	CCLE	RAF265	2.7089
ACH-000007	Colon/Colorectal Cancer	p.E204V (No)	CCLE	PLX4720	8
ACH-000007	Colon/Colorectal Cancer	p.E204V (No)	CCLE	RAF265	1.0833
ACH-000007	Colon/Colorectal Cancer	p.E204L (No)	CCLE	PLX4720	8
ACH-000007	Colon/Colorectal Cancer	p.E204L (No)	CCLE	RAF265	1.0833
ACH-000007	Colon/Colorectal Cancer	p.E204* (No)	CCLE	PLX4720	8
ACH-000007	Colon/Colorectal Cancer	p.E204* (No)	CCLE	RAF265	1.0833
ACH-000552	Colon/Colorectal Cancer	p.T119S (Yes)	CCLE	PLX4720	1.6781
ACH-000552	Colon/Colorectal Cancer	p.T119S (Yes)	CCLE	RAF265	0.8196
ACH-000876	Breast Cancer	p.P74A (No)	CCLE	PLX4720	8
ACH-000876	Breast Cancer	p.P74A (No)	CCLE	RAF265	1.7842
ACH-000573	Breast Cancer	p.GAGA30del (No)	CCLE	PLX4720	8
ACH-000573	Breast Cancer	p.GAGA30del (No)	CCLE	RAF265	2.5681
ACH-000581	Gastric Cancer	p.GAGA30del (No)	CCLE	PLX4720	8
ACH-000581	Gastric Cancer	p.GAGA30del (No)	CCLE	RAF265	0.7355
ACH-000588	Myeloma	p.D22N (No)	CCLE	PLX4720	8
ACH-000588	Myeloma	p.D22N (No)	CCLE	RAF265	8
ACH-000983	Leukemia	p.D22N (No)	CCLE	PLX4720	8
ACH-000983	Leukemia	p.D22N (No)	CCLE	RAF265	1.4428
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	HG6-64-1	0.784
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	PLX-4720	16.2594
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	PLX-4720	100.3989
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	Dabrafenib	82.7468
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	RAF_9304	16.5565
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	PLX-4720	117.36
SIDM00333	UCEC\|endometrium	p.S727G (No)	GDSC	Dabrafenib	57.308
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.0182
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.9741
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.5513
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.8656
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.4113
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0157
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.3509
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.1975
SIDM01079	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0418
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	4.2515
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	21.6852
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	107.8543
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	19.3464
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	4.0953
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	41.9749
SIDM00515	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	10.7756
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.8358
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.3666
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.418
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6834
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0128
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.4653
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.0703
SIDM00795	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0312
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	HG6-64-1	2.6196
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	PLX-4720	11.7575
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	SB590885	26.6515
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	PLX-4720	21.026
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	Dabrafenib	17.6554
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G466V (No)	GDSC	RAF_9304	9.646
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	0.4556
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	0.1948
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	0.1844
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	2.8929
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	1.827
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	1.8882
SIDM00826	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	0.9285
SIDM00081	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	17.8392
SIDM00081	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.7996
SIDM00081	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.745
SIDM00081	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0414
SIDM00081	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.1934
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	23.4209
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.3144
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	1.1052
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.2105
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0228
SIDM00175	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.4072
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	0.3952
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	3.1222
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	6.6318
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	6.8551
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.3819
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	2.243
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	18.492
SIDM00997	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	5.8485
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.063
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	4.2356
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.5555
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	1.0791
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.2755
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0352
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.0645
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	5.8655
SIDM00108	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.9654
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	HG6-64-1	2.1006
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	PLX-4720	24.9523
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	SB590885	41.7999
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	PLX-4720	14.2852
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	Dabrafenib	3.048
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	RAF_9304	10.4101
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	PLX-4720	29.876
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.V600E (No)	GDSC	Dabrafenib	28.237
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.123
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	9.5257
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	26.0896
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	17.6452
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	23.313
SIDM00797	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	54.226
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.7478
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	5.4418
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	12.8241
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	32.6095
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	6.0803
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	5.6203
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	16.209
SIDM00976	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	20.102
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	AZ628	2.1021
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	19.2154
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	11.1863
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	20.4888
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	6.7105
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	0.0816
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	0.6322
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	8.8807
SIDM00527	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	2.5883
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	AZ628	2.1021
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	HG6-64-1	19.2154
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	PLX-4720	11.1863
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	SB590885	20.4888
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	PLX-4720	6.7105
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	Dabrafenib	0.0816
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	RAF_9304	0.6322
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	PLX-4720	8.8807
SIDM00527	COREAD\|large_intestine	p.V600M (No)	GDSC	Dabrafenib	2.5883
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.4911
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	33.3135
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.8179
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	1.6525
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	6.6069
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0437
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	3.7015
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	13.689
SIDM01107	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.5087
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	HG6-64-1	1.4481
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	PLX-4720	135.7882
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	SB590885	18.3599
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	PLX-4720	172.9987
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	Dabrafenib	25.7373
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	RAF_9304	5.0645
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	PLX-4720	266.66
SIDM00146	BRCA\|breast	p.G464V (No)	GDSC	Dabrafenib	74.817
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.7429
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	90.583
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	2.6462
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6485
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0242
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.1738
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	8.86
SIDM00974	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0691
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	AZ628	13.5498
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	HG6-64-1	71.8037
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	PLX-4720	7.4528
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	SB590885	12.2105
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	PLX-4720	21.3523
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	Dabrafenib	3.4676
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	RAF_9304	4.0747
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	PLX-4720	3.2582
SIDM01012	CLL\|lymphoid_neoplasm_other	p.K601N (No)	GDSC	Dabrafenib	0.7355
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.0407
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.424
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.4653
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.7453
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.8377
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.065
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.6961
SIDM00801	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.3076
SIDM00337	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.4113
SIDM00337	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.0916
SIDM00337	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6506
SIDM00337	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0183
SIDM00337	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.1851
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	2.2277
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	5.4267
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	3.2504
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.9954
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0409
SIDM00126	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.5765
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	AZ628	0.6784
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	HG6-64-1	13.7444
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	PLX-4720	239.1703
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	SB590885	71.3856
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	PLX-4720	132.5968
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	Dabrafenib	80.713
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	RAF_9304	2.2841
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	PLX-4720	136.47
SIDM00677	COREAD\|large_intestine	p.E204* (No)	GDSC	Dabrafenib	69.152
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.0482
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.235
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.716
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.6535
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	6.9841
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.1098
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	4.3918
SIDM00909	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.0444
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (No)	GDSC	PLX-4720	12.5075
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (No)	GDSC	SB590885	25.3313
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (No)	GDSC	PLX-4720	16.1451
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (No)	GDSC	Dabrafenib	1.7787
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (No)	GDSC	RAF_9304	0.1572
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (No)	GDSC	PLX-4720	11.655
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A404fs*9 (No)	GDSC	Dabrafenib	7.2347
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	4.0959
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.3271
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.1691
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.8412
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0223
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.3941
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.716
SIDM00003	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0291
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	AZ628	0.0612
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	2.3707
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	45.6741
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	7.5353
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	28.6275
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	1.7649
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	1.0174
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	18.61
SIDM01090	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	4.2239
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.4292
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	9.0433
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.2592
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0785
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.8168
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	4.8807
SIDM01106	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	1.4474
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.031
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.815
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	7.8042
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	4.34
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.438
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.1077
SIDM00516	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.3563
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	2.766
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	5.5788
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	5.252
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	1.786
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	0.5692
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	47.052
SIDM00945	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	0.1633
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	19.3586
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	29.6014
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	13.5538
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	4.4819
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	6.2087
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	21.224
SIDM00498	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	14.985
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	AZ628	47.4424
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	HG6-64-1	1.3276
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	PLX-4720	14.6807
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	SB590885	60.1877
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	PLX-4720	9.0501
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	Dabrafenib	0.3084
SIDM00575	LGG\|glioma	p.V600E (No)	GDSC	RAF_9304	8.155
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	2.2096
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	4.8529
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	2.515
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	4.163
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.1024
SIDM01105	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.4877
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	AZ628	0.111
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	1.4595
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	0.9686
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	1.8922
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.0185
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	0.3929
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	3.3546
SIDM00056	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.2933
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.7356
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.2481
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.0847
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.201
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0111
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.0885
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6414
SIDM01066	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0346
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	HG6-64-1	0.4194
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	36.8996
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	SB590885	10.9472
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	43.6899
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	3.2771
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	RAF_9304	6.9736
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	33.427
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	13.141
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	2.2766
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.8579
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.4844
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.681
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.4335
SIDM00401	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	3.0612
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	0.4977
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	6.8051
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	4.5796
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	5.8358
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.0588
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	1.6847
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	10.508
SIDM00600	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	6.4848
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.7143
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.3347
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.0775
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.3479
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.01
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.1192
SIDM00129	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.4551
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	4.1969
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	27.9632
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	46.1024
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	60.9245
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	29.5401
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	7.6081
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	45.522
SIDM00812	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	7.3583
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	AZ628	12.7473
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	HG6-64-1	2.8103
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	44.5673
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	SB590885	71.5953
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	174.065
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	Dabrafenib	178.0424
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	RAF_9304	26.29
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	15.929
SIDM00492	GBM\|glioma	p.V600E (No)	GDSC	Dabrafenib	6.1246
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V600E (No)	GDSC	AZ628	0.0193
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V600E (No)	GDSC	HG6-64-1	0.8979
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (No)	GDSC	AZ628	7.8207
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (No)	GDSC	HG6-64-1	2.2575
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (No)	GDSC	PLX-4720	33.6635
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (No)	GDSC	SB590885	63.0315
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (No)	GDSC	PLX-4720	52.979
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (No)	GDSC	Dabrafenib	34.8313
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (No)	GDSC	RAF_9304	8.2806
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (No)	GDSC	PLX-4720	23.185
SIDM01088	UNCLASSIFIED\|endometrium	p.P403fs*8 (No)	GDSC	Dabrafenib	136.69
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	AZ628	0.1194
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	HG6-64-1	0.5302
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	5.1001
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	SB590885	26.7941
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	5.3141
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	0.0952
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	RAF_9304	1.9808
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	31.912
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	49.59
SIDM00220	OV\|ovary	p.P403fs*8 (No)	GDSC	HG6-64-1	0.958
SIDM00220	OV\|ovary	p.P403fs*8 (No)	GDSC	PLX-4720	34.7171
SIDM00220	OV\|ovary	p.P403fs*8 (No)	GDSC	SB590885	34.8119
SIDM00220	OV\|ovary	p.P403fs*8 (No)	GDSC	PLX-4720	50.9251
SIDM00220	OV\|ovary	p.P403fs*8 (No)	GDSC	Dabrafenib	8.004
SIDM00220	OV\|ovary	p.P403fs*8 (No)	GDSC	RAF_9304	9.9127
SIDM00220	OV\|ovary	p.P403fs*8 (No)	GDSC	Dabrafenib	19.044
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	AZ628	0.1111
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	1.046
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	7.6466
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	9.4412
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	7.7144
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	3.7886
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	2.6704
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	7.57
SIDM00660	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	8.4019
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	10.3276
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.9015
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.7516
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	15.0547
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	2.0225
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	5.4464
SIDM01000	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	3.3405
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	27.6796
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	6.6239
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	2.3761
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	4.0624
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.1069
SIDM00955	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	2.9833
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.0214
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.3301
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.8578
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.4424
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.6006
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.1008
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.7017
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.0559
SIDM00695	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0451
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.3397
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	10.4879
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	5.9803
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	19.7206
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	2.5556
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	8.1401
SIDM00973	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	26.799
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	1.8268
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	29.2379
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	18.8072
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	81.458
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	6.4378
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	9.2259
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	104.73
SIDM00996	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	19.445
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.073
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.4072
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.713
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.4018
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0093
SIDM01242	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.4251
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	AZ628	22.0213
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	HG6-64-1	34.267
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	PLX-4720	97.014
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	SB590885	56.5869
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	PLX-4720	17.5982
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	Dabrafenib	11.2326
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	RAF_9304	4.2278
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	PLX-4720	659.27
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G466V (No)	GDSC	Dabrafenib	241.06
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	7.2849
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	0.725
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	1.5055
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	1.7193
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.0343
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	0.4244
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	8.6722
SIDM00987	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	1.5199
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (No)	GDSC	AZ628	1.5027
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (No)	GDSC	HG6-64-1	1.5217
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (No)	GDSC	PLX-4720	152.3118
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (No)	GDSC	SB590885	47.7205
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (No)	GDSC	PLX-4720	147.618
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (No)	GDSC	Dabrafenib	32.667
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (No)	GDSC	RAF_9304	78.5966
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (No)	GDSC	PLX-4720	195.01
SIDM00150	COREAD\|large_intestine	p.A404fs*9 (No)	GDSC	Dabrafenib	19.04
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.1752
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.7926
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	9.7138
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.4809
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.1633
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.7912
SIDM00975	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	2.7207
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	3.1424
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.1588
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.8132
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	2.6247
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.1281
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0515
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.4978
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	9.836
SIDM00149	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	3.7246
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	AZ628	0.6392
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	HG6-64-1	7.3787
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	PLX-4720	6.7394
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	SB590885	6.333
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	PLX-4720	2.4495
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	Dabrafenib	0.0554
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	RAF_9304	0.5014
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	PLX-4720	18.975
SIDM00861	UNCLASSIFIED\|ovary	p.V600E (No)	GDSC	Dabrafenib	1.4074
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	HG6-64-1	0.3982
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	4.8813
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	SB590885	6.1877
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	5.925
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	0.1105
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	RAF_9304	3.5103
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	PLX-4720	3.5991
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.V600E (No)	GDSC	Dabrafenib	14.611
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	HG6-64-1	0.7113
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	4.5807
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	SB590885	3.6674
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	9.4056
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	Dabrafenib	0.2694
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	RAF_9304	2.0031
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	PLX-4720	24.347
SIDM00867	GBM\|glioma	p.V600E (No)	GDSC	Dabrafenib	6.4612
SIDM00319	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	9.5978
SIDM00319	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	92.1974
SIDM00319	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	37.7428
SIDM00319	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	132.8688
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	HG6-64-1	2.4177
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	4.7456
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	SB590885	4.4704
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	6.9569
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	RAF_9304	1.3468
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	PLX-4720	7.1667
SIDM00136	COREAD\|large_intestine	p.V600E (No)	GDSC	Dabrafenib	1.1932
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (No)	GDSC	AZ628	7.6703
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (No)	GDSC	HG6-64-1	2.5897
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (No)	GDSC	PLX-4720	14.397
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (No)	GDSC	SB590885	32.9239
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (No)	GDSC	PLX-4720	89.2636
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (No)	GDSC	Dabrafenib	6.0411
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (No)	GDSC	RAF_9304	5.663
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (No)	GDSC	PLX-4720	13.009
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A404fs*9 (No)	GDSC	Dabrafenib	3.0189
SIDM00663	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	2.7738
SIDM00663	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	2.3063
SIDM00663	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	3.5247
SIDM00663	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	5.0274
SIDM00663	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.657
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	2.6125
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	9.7105
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	40.8578
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	38.8484
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	4.9847
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	19.631
SIDM01087	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	86.343
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	HG6-64-1	61.9214
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	PLX-4720	167.3606
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	SB590885	91.3112
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	RAF_9304	8.4746
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	PLX-4720	34.291
SIDM00541	COREAD\|large_intestine	p.N581Y (No)	GDSC	Dabrafenib	41.914
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	HG6-64-1	0.3475
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	PLX-4720	9.3928
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	SB590885	12.1057
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	PLX-4720	8.9339
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	RAF_9304	4.5987
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	PLX-4720	17.166
SIDM01110	LIHC\|liver	p.V600E (No)	GDSC	Dabrafenib	60.518
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	HG6-64-1	0.9491
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	PLX-4720	20.0525
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	SB590885	47.0321
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	PLX-4720	46.5981
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	Dabrafenib	17.3698
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	RAF_9304	18.4974
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	PLX-4720	28.557
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.G469A (No)	GDSC	Dabrafenib	45.968
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	AZ628	0.4774
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.654
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	11.4967
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	8.7089
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	11.0183
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.4923
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	4.3033
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	14.364
SIDM00225	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	33.301
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	0.3248
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	5.7641
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	22.8943
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	9.3493
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.21
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	3.4172
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	24.878
SIDM00992	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	8.1065
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	33.9182
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.9826
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	1.8369
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.8845
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.2461
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.3552
SIDM00080	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	18.338
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	PLX-4720	114.7274
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	SB590885	37.3331
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	PLX-4720	187.5677
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	Dabrafenib	14.6545
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	RAF_9304	27.2961
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	PLX-4720	232.94
SIDM00417	MM\|myeloma	p.K601N (No)	GDSC	Dabrafenib	3.7526
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	79.6307
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.2274
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.1377
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.0683
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0128
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.3932
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.3399
SIDM00890	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0431
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.4918
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.214
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.1252
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.8329
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.029
SIDM01240	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.5179
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.7973
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	11.1957
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	7.681
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	14.267
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	3.8498
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	16.327
SIDM01060	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	7.9645
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	HG6-64-1	0.7973
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	PLX-4720	11.1957
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	SB590885	7.681
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	PLX-4720	14.267
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	RAF_9304	3.8498
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	PLX-4720	16.327
SIDM01060	SKCM\|melanoma	p.V600M (No)	GDSC	Dabrafenib	7.9645
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	PLX-4720	51.9587
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	PLX-4720	155.6419
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	Dabrafenib	2.9927
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	RAF_9304	0.1818
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	PLX-4720	21.511
SIDM00291	SKCM\|melanoma	p.G469V (No)	GDSC	Dabrafenib	13.473
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	1.1153
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	76.4739
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	44.4897
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6548
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0317
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.5022
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6024
SIDM00107	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0438
SIDM01104	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	41.0719
SIDM01104	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	143.8874
SIDM01104	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	44.0069
SIDM01104	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	69.8297
SIDM01104	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	17.3207
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	HG6-64-1	0.6707
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	1.7545
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	SB590885	12.7808
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	1.8853
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	0.0623
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	RAF_9304	0.281
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	PLX-4720	4.1829
SIDM00496	THCA\|thyroid	p.V600E (No)	GDSC	Dabrafenib	3.9789
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	AZ628	0.0335
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	HG6-64-1	1.3842
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	PLX-4720	0.2116
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	SB590885	0.1301
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	PLX-4720	0.9465
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	Dabrafenib	0.0111
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	RAF_9304	0.2852
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	PLX-4720	0.3942
SIDM01001	BRCA\|breast	p.V600E (No)	GDSC	Dabrafenib	0.0062
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.8374
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.1263
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	5.276
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.2087
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0412
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	1.7572
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	3.0651
SIDM00857	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.4851
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	HG6-64-1	0.7489
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.1371
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	SB590885	0.286
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	0.6227
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0427
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	RAF_9304	0.2362
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	PLX-4720	1.1234
SIDM00284	SKCM\|melanoma	p.V600E (No)	GDSC	Dabrafenib	0.0986
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	PLX-4720	23.5475
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	SB590885	3.6874
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	PLX-4720	28.9959
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	Dabrafenib	1.0539
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	RAF_9304	1.027
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	PLX-4720	269.4
SIDM00968	OV\|ovary	p.G464E (No)	GDSC	Dabrafenib	13.331
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	HG6-64-1	0.4144
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	PLX-4720	128.9641
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	SB590885	58.8035
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	PLX-4720	80.6032
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	Dabrafenib	16.7904
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	RAF_9304	3.2104
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	PLX-4720	172.85
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.L485_P490delinsY (No)	GDSC	Dabrafenib	84.017
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	AZ628	5.616
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	HG6-64-1	15.5807
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	PLX-4720	83.1165
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	SB590885	35.7633
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	PLX-4720	124.3484
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	Dabrafenib	121.7009
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	RAF_9304	4.9625
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	PLX-4720	366.19
SIDM00578	NB\|neuroblastoma	p.I326V (No)	GDSC	Dabrafenib	312.91
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	AZ628	201.7796
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	HG6-64-1	44.2281
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	SB590885	5.4412
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	PLX-4720	202.1652
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	Dabrafenib	277.3225
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	RAF_9304	52.7835
SIDM00772	BRCA\|breast	p.E296K (No)	GDSC	Dabrafenib	28.631
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	HG6-64-1	2.4582
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	PLX-4720	40.8215
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	SB590885	53.7745
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	PLX-4720	100.7327
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	Dabrafenib	38.4906
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	RAF_9304	5.4494
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	PLX-4720	40.399
SIDM00210	UNCLASSIFIED\|ovary	p.V226M (No)	GDSC	Dabrafenib	49.801
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	HG6-64-1	1.4679
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	PLX-4720	35.2742
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	SB590885	17.3394
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	PLX-4720	217.5603
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	Dabrafenib	207.0116
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	RAF_9304	7.5345
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	PLX-4720	413.5
SIDM00680	COREAD\|large_intestine	p.D211G (No)	GDSC	Dabrafenib	257.61
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	HG6-64-1	5.9278
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	PLX-4720	165.7139
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	SB590885	32.1117
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	PLX-4720	70.6978
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	Dabrafenib	33.0926
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	RAF_9304	14.3405
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	PLX-4720	173.1
SIDM00499	PRAD\|prostate	p.L597R (No)	GDSC	Dabrafenib	428.57
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	HG6-64-1	4.4843
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	PLX-4720	30.3453
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	SB590885	5.2656
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	PLX-4720	100.8936
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	Dabrafenib	69.1367
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	RAF_9304	10.8244
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	PLX-4720	24.619
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I326V (No)	GDSC	Dabrafenib	23.109
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	HG6-64-1	0.7148
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	PLX-4720	125.5491
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	SB590885	62.7746
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	PLX-4720	161.0492
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	Dabrafenib	114.1437
SIDM00131	GBM\|glioma	p.R146Q (No)	GDSC	RAF_9304	6.5207
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	PLX-4720	18.9574
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	SB590885	218.9344
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	PLX-4720	172.243
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	Dabrafenib	51.2182
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	RAF_9304	14.3193
SIDM00777	COREAD\|large_intestine	p.G596R (No)	GDSC	Dabrafenib	20.359
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	AZ628	0.6784
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	HG6-64-1	13.7444
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	PLX-4720	239.1703
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	SB590885	71.3856
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	PLX-4720	132.5968
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	Dabrafenib	80.713
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	RAF_9304	2.2841
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	PLX-4720	136.47
SIDM00677	COREAD\|large_intestine	p.E204V (No)	GDSC	Dabrafenib	69.152
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	PLX-4720	886.8253
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	SB590885	437.8463
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	PLX-4720	471.7159
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	Dabrafenib	226.941
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	RAF_9304	184.3223
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	PLX-4720	214.19
SIDM00971	BRCA\|breast	p.I326T (No)	GDSC	Dabrafenib	1495
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	PLX-4720	188.8846
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	SB590885	85.2709
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	PLX-4720	134.821
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	Dabrafenib	15.5531
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	RAF_9304	4.8864
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	PLX-4720	269.92
SIDM00214	COREAD\|large_intestine	p.R726C (No)	GDSC	Dabrafenib	91.258
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	HG6-64-1	0.958
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	PLX-4720	34.7171
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	SB590885	34.8119
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	PLX-4720	50.9251
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	Dabrafenib	8.004
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	RAF_9304	9.9127
SIDM00220	OV\|ovary	p.A747V (No)	GDSC	Dabrafenib	19.044
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	HG6-64-1	0.3902
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	26.3838
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	SB590885	28.6295
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	44.5205
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	Dabrafenib	101.4116
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	RAF_9304	4.9368
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	56.092
SIDM01030	ESCA\|oesophagus	p.I326V (No)	GDSC	Dabrafenib	135.91
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	HG6-64-1	2.595
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	PLX-4720	96.4523
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	SB590885	71.3977
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	PLX-4720	125.1844
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	RAF_9304	4.0883
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	PLX-4720	69.564
SIDM00551	ESCA\|oesophagus	p.C194G (No)	GDSC	Dabrafenib	176.3
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	HG6-64-1	0.6561
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	PLX-4720	47.872
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	SB590885	73.0867
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	PLX-4720	22.7722
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	Dabrafenib	35.4235
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	RAF_9304	4.8508
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	PLX-4720	34.825
SIDM00132	PAAD\|pancreas	p.V487_P492delinsA (No)	GDSC	Dabrafenib	59.149
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	HG6-64-1	113.1124
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	PLX-4720	161.095
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	SB590885	183.4434
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	PLX-4720	219.324
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	Dabrafenib	219.324
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	RAF_9304	50.3157
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	PLX-4720	137.21
SIDM01045	UCEC\|endometrium	p.I326V (No)	GDSC	Dabrafenib	468.69
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	AZ628	6.8003
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	HG6-64-1	12.148
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	100.9473
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	SB590885	107.1339
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	56.948
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	Dabrafenib	21.2137
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	RAF_9304	10.0795
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	PLX-4720	153.48
SIDM00369	ESCA\|oesophagus	p.I326V (No)	GDSC	Dabrafenib	301.82
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	HG6-64-1	0.7143
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	PLX-4720	0.3347
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	SB590885	0.0775
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	PLX-4720	0.3479
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	Dabrafenib	0.01
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	RAF_9304	0.1192
SIDM00129	SKCM\|melanoma	p.G759* (No)	GDSC	PLX-4720	0.4551
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	HG6-64-1	1.1856
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	PLX-4720	29.9772
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	SB590885	9.8517
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	PLX-4720	57.9452
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	Dabrafenib	19.1118
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	RAF_9304	6.1975
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	PLX-4720	297.21
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.S683N (No)	GDSC	Dabrafenib	218.02
SIDM00217	COREAD\|large_intestine	p.V120I (Yes)	GDSC	PLX-4720	173.5516
SIDM00217	COREAD\|large_intestine	p.V120I (Yes)	GDSC	Dabrafenib	88.5347
SIDM00217	COREAD\|large_intestine	p.V120I (Yes)	GDSC	RAF_9304	59.291
SIDM00217	COREAD\|large_intestine	p.V120I (Yes)	GDSC	PLX-4720	334.77
SIDM00217	COREAD\|large_intestine	p.V120I (Yes)	GDSC	Dabrafenib	175.03
SIDM00217	COREAD\|large_intestine	p.S76P (No)	GDSC	PLX-4720	173.5516
SIDM00217	COREAD\|large_intestine	p.S76P (No)	GDSC	Dabrafenib	88.5347
SIDM00217	COREAD\|large_intestine	p.S76P (No)	GDSC	RAF_9304	59.291
SIDM00217	COREAD\|large_intestine	p.S76P (No)	GDSC	PLX-4720	334.77
SIDM00217	COREAD\|large_intestine	p.S76P (No)	GDSC	Dabrafenib	175.03
SIDM00889	CESC\|cervix	p.A115V (Yes)	GDSC	HG6-64-1	0.8731
SIDM00889	CESC\|cervix	p.A115V (Yes)	GDSC	PLX-4720	63.3044
SIDM00889	CESC\|cervix	p.A115V (Yes)	GDSC	SB590885	75.8924
SIDM00889	CESC\|cervix	p.A115V (Yes)	GDSC	PLX-4720	41.9715
SIDM00889	CESC\|cervix	p.A115V (Yes)	GDSC	Dabrafenib	17.5007
SIDM00889	CESC\|cervix	p.A115V (Yes)	GDSC	RAF_9304	8.3295
SIDM00889	CESC\|cervix	p.A115V (Yes)	GDSC	PLX-4720	42.328
SIDM00889	CESC\|cervix	p.A115V (Yes)	GDSC	Dabrafenib	80.283
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	AZ628	1.5027
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	HG6-64-1	1.5217
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	PLX-4720	152.3118
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	SB590885	47.7205
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	PLX-4720	147.618
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	Dabrafenib	32.667
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	RAF_9304	78.5966
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	PLX-4720	195.01
SIDM00150	COREAD\|large_intestine	p.A712T (No)	GDSC	Dabrafenib	19.04
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	HG6-64-1	2.8556
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	PLX-4720	129.431
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	SB590885	67.683
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	PLX-4720	214.1023
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	Dabrafenib	122.2077
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	RAF_9304	9.3137
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	PLX-4720	142.36
SIDM00267	UNCLASSIFIED\|biliary_tract	p.V645I (No)	GDSC	Dabrafenib	353.77
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	HG6-64-1	6.8422
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	PLX-4720	95.7786
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	SB590885	1.8165
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	PLX-4720	58.1484
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	Dabrafenib	0.0264
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	RAF_9304	0.5262
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	PLX-4720	141.51
SIDM01141	OV\|ovary	p.N486_P490delNVTAP (No)	GDSC	Dabrafenib	0.7779
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	AZ628	55.9174
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	HG6-64-1	40.8254
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	PLX-4720	60.7242
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	SB590885	93.9636
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	PLX-4720	86.4617
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	Dabrafenib	110.6714
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	RAF_9304	84.0123
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.A320S (No)	GDSC	PLX-4720	759.01
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	AZ628	1.1505
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	HG6-64-1	2.3141
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	PLX-4720	66.5647
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	SB590885	27.3066
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	PLX-4720	33.2664
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	Dabrafenib	65.027
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	RAF_9304	4.539
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	PLX-4720	46.626
SIDM00423	DLBC\|B_cell_lymphoma	p.T599_V600insT (No)	GDSC	Dabrafenib	40.909
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	HG6-64-1	11.5239
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	PLX-4720	178.9034
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	SB590885	72.958
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	PLX-4720	121.4102
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	Dabrafenib	31.2908
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	RAF_9304	6.5261
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	PLX-4720	102.35
SIDM00534	COREAD\|large_intestine	p.R354Q (No)	GDSC	Dabrafenib	277.09
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	AZ628	3.1424
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	HG6-64-1	1.1588
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	PLX-4720	2.8132
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	SB590885	2.6247
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	PLX-4720	3.1281
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	Dabrafenib	0.0515
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	RAF_9304	0.4978
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	PLX-4720	9.836
SIDM00149	SKCM\|melanoma	p.I208V (No)	GDSC	Dabrafenib	3.7246
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	HG6-64-1	5.1355
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	PLX-4720	140.6543
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	SB590885	7.9844
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	PLX-4720	143.2376
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	Dabrafenib	138.0282
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	RAF_9304	9.7863
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	PLX-4720	117.58
SIDM00487	COREAD\|large_intestine	p.R506G (No)	GDSC	Dabrafenib	260.62
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	HG6-64-1	5.1355
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	PLX-4720	140.6543
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	SB590885	7.9844
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	PLX-4720	143.2376
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	Dabrafenib	138.0282
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	RAF_9304	9.7863
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	PLX-4720	117.58
SIDM00487	COREAD\|large_intestine	p.S273N (No)	GDSC	Dabrafenib	260.62
SIDM00392	SKCM\|melanoma	p.D287H (No)	GDSC	HG6-64-1	2.1878
SIDM00392	SKCM\|melanoma	p.D287H (No)	GDSC	PLX-4720	33.9119
SIDM00392	SKCM\|melanoma	p.D287H (No)	GDSC	PLX-4720	106.5127
SIDM00392	SKCM\|melanoma	p.D287H (No)	GDSC	Dabrafenib	25.2998
SIDM00392	SKCM\|melanoma	p.D287H (No)	GDSC	RAF_9304	1.1505
SIDM00392	SKCM\|melanoma	p.E275K (No)	GDSC	HG6-64-1	2.1878
SIDM00392	SKCM\|melanoma	p.E275K (No)	GDSC	PLX-4720	33.9119
SIDM00392	SKCM\|melanoma	p.E275K (No)	GDSC	PLX-4720	106.5127
SIDM00392	SKCM\|melanoma	p.E275K (No)	GDSC	Dabrafenib	25.2998
SIDM00392	SKCM\|melanoma	p.E275K (No)	GDSC	RAF_9304	1.1505
SIDM00136	COREAD\|large_intestine	p.T119S (Yes)	GDSC	HG6-64-1	2.4177
SIDM00136	COREAD\|large_intestine	p.T119S (Yes)	GDSC	PLX-4720	4.7456
SIDM00136	COREAD\|large_intestine	p.T119S (Yes)	GDSC	SB590885	4.4704
SIDM00136	COREAD\|large_intestine	p.T119S (Yes)	GDSC	PLX-4720	6.9569
SIDM00136	COREAD\|large_intestine	p.T119S (Yes)	GDSC	RAF_9304	1.3468
SIDM00136	COREAD\|large_intestine	p.T119S (Yes)	GDSC	PLX-4720	7.1667
SIDM00136	COREAD\|large_intestine	p.T119S (Yes)	GDSC	Dabrafenib	1.1932
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	HG6-64-1	1.2179
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	PLX-4720	67.9463
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	SB590885	68.2782
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	PLX-4720	44.0458
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	Dabrafenib	5.9294
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	RAF_9304	4.9226
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	PLX-4720	330.3
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L597V (No)	GDSC	Dabrafenib	35.497
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	HG6-64-1	2.2635
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	PLX-4720	83.0188
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	SB590885	74.948
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	PLX-4720	89.9396
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	Dabrafenib	31.3018
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	RAF_9304	24.7008
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	PLX-4720	38.82
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.E375D (No)	GDSC	Dabrafenib	108.7
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	AZ628	7.3299
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	HG6-64-1	2.3565
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	PLX-4720	7.3671
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	SB590885	5.8546
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	PLX-4720	24.5475
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	Dabrafenib	7.0761
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	RAF_9304	22.3291
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	PLX-4720	106.13
SIDM01259	ALL\|lymphoblastic_leukemia	p.D361G (No)	GDSC	Dabrafenib	19.14
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	HG6-64-1	0.7938
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	PLX-4720	44.089
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	SB590885	41.2288
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	PLX-4720	89.9366
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	Dabrafenib	88.9832
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	RAF_9304	5.9598
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	PLX-4720	69.682
SIDM00537	COREAD\|large_intestine	p.T529A (No)	GDSC	Dabrafenib	203.53
SIDM01146	STAD\|stomach	p.A400V (No)	GDSC	AZ628	0.4586
SIDM01146	STAD\|stomach	p.A400V (No)	GDSC	HG6-64-1	1.2271
SIDM01146	STAD\|stomach	p.A400V (No)	GDSC	PLX-4720	27.2982
SIDM01146	STAD\|stomach	p.A400V (No)	GDSC	SB590885	10.1108
SIDM01146	STAD\|stomach	p.A400V (No)	GDSC	PLX-4720	181.7476
SIDM01146	STAD\|stomach	p.A400V (No)	GDSC	Dabrafenib	48.7313
SIDM01146	STAD\|stomach	p.A400V (No)	GDSC	RAF_9304	9.7076
SIDM01146	STAD\|stomach	p.A400V (No)	GDSC	PLX-4720	147.53
SIDM01146	STAD\|stomach	p.A400V (No)	GDSC	Dabrafenib	116.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60318	Germinal-center associated nuclear protein	DEG_SPOP_SBC_1	197:201	VTSSS	SPOP	0.938	More...
P02533	Keratin, type I cytoskeletal 14	DEG_SPOP_SBC_1	441:445	VTSSS	SPOP	0.9845	More...
P15056	Serine/threonine-protein kinase B-raf	DEG_SPOP_SBC_1	120:124	VTSSS	SPOP	0.9734	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	207:211	VTSSS	SPOP	0.9601	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	2008:2012	VTSSS	SPOP	0.9659	More...
Q14161	ARF GTPase-activating protein GIT2	DEG_SPOP_SBC_1	554:558	VTSSS	SPOP	0.9992	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	3641:3645	VTSSS	SPOP	0.8527	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3548:3552	VTSSS	SPOP	0.9001	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	442:446	VTSSS	SPOP	0.9354	More...
Q8IY22	C-Maf-inducing protein	DEG_SPOP_SBC_1	3:7	VTSSS	SPOP	0.9749	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	108:112	VTSSS	SPOP	0.9792	More...
Q8TF40	Folliculin-interacting protein 1	DEG_SPOP_SBC_1	104:108	VTSSS	SPOP	0.9551	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3897:3901	VTSSS	SPOP	0.9951	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4932:4936	VTSSS	SPOP	0.8363	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7283:7287	VTSSS	SPOP	0.9977	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8158:8162	VTSSS	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11046:11050	VTSSS	SPOP	0.9225	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	565:569	VTSSS	SPOP	0.9982	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1615:1619	VTSSS	SPOP	0.8983	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	965:969	VTSSS	SPOP	0.9734	More...
A6NNH2	Protein FAM90A27P	DEG_SPOP_SBC_1	449:453	VTSSS	SPOP	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSSS

Degron related mutations and impact score

Drug responses associated with BRAF mutations

All proteins holding degron of VTSSS