DegronMD - P02533(KRT14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S432F	TCGA-17-Z059	LUAD	TCGA	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation blocking phosphorylation signal	0.5278
p.R439T	TCGA-39-5022	LUSC	TCGA	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.2778
p.R439T	DO27604	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.2778
p.V452A	TCGA-AD-6964	COAD	TCGA	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452A	DO8360	COAD	ICGC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.D440N	TCGA-QC-A7B5	SARC	TCGA	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.D440N	DO220239	SARC	ICGC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.R449C	DO234307	ESAD	ICGC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.2222
p.R446H	DO232224	PBCA	ICGC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.V452I	SIDM00253	Neuroblastoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM01183	Other Solid Cancers	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00107	Melanoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM01878	Non-Cancerous	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00693	Bladder Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00286	Neuroblastoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00995	Other Solid Cancers	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00767	Small Cell Lung Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00335	Endometrial Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM01732	Non-Cancerous	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00927	Small Cell Lung Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00542	Glioblastoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00123	Kidney Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00184	Melanoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM00701	Non-Cancerous	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM01529	Bladder Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.V452I	SIDM01615	Non-Small Cell Lung Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389

Kaplan plot for KRT14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT14

UniProt ID: P02533

Entrez ID: 3861

Protein name: Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT14 in