DegronMD

Uniprot ID: P02533

Source protein: Keratin, type I cytoskeletal 14

Source gene: KRT14

Class: DEG_SPOP_SBC_1

Location: 441:445

E3 ligase: SPOP

DEGRON score: 0.9845

ASA_SCORE: 81.64

COIL: 0.7798

CONS_SCORE: 0.4202

DSS_SCORE: 0.6091

HELIX: 0.0148

FCONS_SCORE: 0.8613

RIG_SCORE: 0.6391

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S432F	TCGA-17-Z059	LUAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.5278
p.R439T	TCGA-39-5022	LUSC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.2778
p.R439T	DO27604	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.2778
p.V452A	TCGA-AD-6964	COAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452A	DO8360	COAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.D440N	TCGA-QC-A7B5	SARC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.3056
p.D440N	DO220239	SARC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.3056
p.R449C	DO234307	ESAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.2222
p.R446H	DO232224	PBCA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.3056
p.V452I	SIDM00253	Neuroblastoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM01183	Other Solid Cancers	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00107	Melanoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM01878	Non-Cancerous	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00693	Bladder Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00286	Neuroblastoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00995	Other Solid Cancers	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00767	Small Cell Lung Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00335	Endometrial Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM01732	Non-Cancerous	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00927	Small Cell Lung Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00542	Glioblastoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00123	Kidney Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00184	Melanoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM00701	Non-Cancerous	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM01529	Bladder Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.V452I	SIDM01615	Non-Small Cell Lung Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60318	Germinal-center associated nuclear protein	DEG_SPOP_SBC_1	197:201	VTSSS	SPOP	0.938	More...
P02533	Keratin, type I cytoskeletal 14	DEG_SPOP_SBC_1	441:445	VTSSS	SPOP	0.9845	More...
P15056	Serine/threonine-protein kinase B-raf	DEG_SPOP_SBC_1	120:124	VTSSS	SPOP	0.9734	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	207:211	VTSSS	SPOP	0.9601	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	2008:2012	VTSSS	SPOP	0.9659	More...
Q14161	ARF GTPase-activating protein GIT2	DEG_SPOP_SBC_1	554:558	VTSSS	SPOP	0.9992	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	3641:3645	VTSSS	SPOP	0.8527	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3548:3552	VTSSS	SPOP	0.9001	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	442:446	VTSSS	SPOP	0.9354	More...
Q8IY22	C-Maf-inducing protein	DEG_SPOP_SBC_1	3:7	VTSSS	SPOP	0.9749	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	108:112	VTSSS	SPOP	0.9792	More...
Q8TF40	Folliculin-interacting protein 1	DEG_SPOP_SBC_1	104:108	VTSSS	SPOP	0.9551	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3897:3901	VTSSS	SPOP	0.9951	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4932:4936	VTSSS	SPOP	0.8363	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7283:7287	VTSSS	SPOP	0.9977	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8158:8162	VTSSS	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11046:11050	VTSSS	SPOP	0.9225	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	565:569	VTSSS	SPOP	0.9982	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1615:1619	VTSSS	SPOP	0.8983	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	965:969	VTSSS	SPOP	0.9734	More...
A6NNH2	Protein FAM90A27P	DEG_SPOP_SBC_1	449:453	VTSSS	SPOP	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSSS

Degron related mutations and impact score

Drug responses associated with KRT14 mutations

All proteins holding degron of VTSSS