DegronMD

Uniprot ID: Q8TF40

Source protein: Folliculin-interacting protein 1

Source gene: FNIP1

Class: DEG_SPOP_SBC_1

Location: 104:108

E3 ligase: SPOP

DEGRON score: 0.9551

ASA_SCORE: 81.76

COIL: 0.87

CONS_SCORE: 0.3208

DSS_SCORE: 0.431

HELIX: 0.1114

FCONS_SCORE: 1.0362

RIG_SCORE: 0.6725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q113H	TCGA-DF-A2KU	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1944
p.Q113H	DO223286	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.V104A	TCGA-FI-A2D5	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.5825
p.V104A	DO41331	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.5825
p.Q118L	TCGA-UB-A7MB	LIHC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.0556
p.Q118L	DO52318	LIHC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.0556
p.Q113R	TCGA-ZQ-A9CR	STAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1944
p.Q113R	DO50145	STAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.S103F	SIDM01169	Ovarian Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.3056
p.S103F	ACH-000885	Ovarian Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.3056
p.S103F	TOV-21G	ovary	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.3056
p.S108F	SIDM00796	Head and Neck Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.7982
p.S108F	ACH-000740	Head and Neck Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.7982
p.S108F	A253	salivary_gland	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.7982
p.L115I	SIDM00217	Colorectal Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.L115I	ACH-000999	Colon/Colorectal Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.1389
p.L115I	SNU-1040	large_intestine	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.S106L	SIDM00839	Colorectal Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.7667
p.S106L	ACH-000950	Colon/Colorectal Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.7667
p.S106L	LoVo	large_intestine	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.7667
p.K102R	ACH-000831	Endometrial/Uterine Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60318	Germinal-center associated nuclear protein	DEG_SPOP_SBC_1	197:201	VTSSS	SPOP	0.938	More...
P02533	Keratin, type I cytoskeletal 14	DEG_SPOP_SBC_1	441:445	VTSSS	SPOP	0.9845	More...
P15056	Serine/threonine-protein kinase B-raf	DEG_SPOP_SBC_1	120:124	VTSSS	SPOP	0.9734	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	207:211	VTSSS	SPOP	0.9601	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	2008:2012	VTSSS	SPOP	0.9659	More...
Q14161	ARF GTPase-activating protein GIT2	DEG_SPOP_SBC_1	554:558	VTSSS	SPOP	0.9992	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	3641:3645	VTSSS	SPOP	0.8527	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3548:3552	VTSSS	SPOP	0.9001	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	442:446	VTSSS	SPOP	0.9354	More...
Q8IY22	C-Maf-inducing protein	DEG_SPOP_SBC_1	3:7	VTSSS	SPOP	0.9749	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	108:112	VTSSS	SPOP	0.9792	More...
Q8TF40	Folliculin-interacting protein 1	DEG_SPOP_SBC_1	104:108	VTSSS	SPOP	0.9551	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3897:3901	VTSSS	SPOP	0.9951	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4932:4936	VTSSS	SPOP	0.8363	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7283:7287	VTSSS	SPOP	0.9977	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8158:8162	VTSSS	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11046:11050	VTSSS	SPOP	0.9225	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	565:569	VTSSS	SPOP	0.9982	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1615:1619	VTSSS	SPOP	0.8983	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	965:969	VTSSS	SPOP	0.9734	More...
A6NNH2	Protein FAM90A27P	DEG_SPOP_SBC_1	449:453	VTSSS	SPOP	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSSS

Degron related mutations and impact score

Drug responses associated with FNIP1 mutations

All proteins holding degron of VTSSS