DegronMD - O60318(MCM3AP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A190S	TCGA-18-3417	LUSC	TCGA	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.A190S	DO26584	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.A1081V	TCGA-19-5956	GBM	TCGA	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2222
p.A1081V	DO13863	GBM	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2222
p.A1081V	DO227905	PBCA	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2222
p.A1081V	DO229542	UTCA	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2222
p.E1078K	TCGA-39-5031	LUSC	TCGA	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.3056
p.E1078K	TCGA-FD-A43P	BLCA	TCGA	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.3056
p.E1078K	TCGA-IB-7651	PAAD	TCGA	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.3056
p.E1078K	DO44049	BLCA	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.3056
p.E1078K	DO26526	LUSC	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.3056
p.E1078K	DO46657	PAAD	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.3056
p.P1069A	TCGA-AA-3715	COAD	TCGA	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.25
p.P1069A	DO8018	COAD	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.25
p.P1068S	TCGA-AA-3715	COAD	TCGA	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2222
p.P1068S	DO8018	COAD	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2222
p.N206H	TCGA-AJ-A3EL	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1944
p.N206H	DO41542	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1944
p.P195H	TCGA-AP-A1DV	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2778
p.P195H	DO43186	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2778
p.N987Y	TCGA-B0-4811	KIRC	TCGA	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation rewiring degron network	0.1944
p.N987Y	DO17552	KIRC	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation rewiring degron network	0.1944
p.A190T	TCGA-B5-A3FC	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.A190T	DO41871	UCEC	ICGC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.Y989H	TCGA-BR-4361	STAD	TCGA	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation rewiring degron network	0.1389
p.Y989H	DO38887	STAD	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation rewiring degron network	0.1389
p.V974A	TCGA-KO-8410	KICH	TCGA	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation rewiring degron network	0.3056
p.V974A	DO220572	KICH	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation rewiring degron network	0.3056
p.K988R	TCGA-XF-AAML	BLCA	TCGA	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation substituting flanking lysine	0.2778
p.K988R	DO51933	BLCA	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation substituting flanking lysine	0.2778
p.F93S	TCGA-XK-AAIW	PRAD	TCGA	PSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.F93S	DO51407	PRAD	ICGC	PSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.C981Y	DO222867	BTCA	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation altering degron motif	0.5976
p.S102L	DO230334	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7667
p.S102L	DO229010	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7667
p.S102L	DO234205	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7667
p.S102L	DO234285	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7667
p.V1062M	DO229346	LAML	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.0556
p.V1062M	SIDM00434	Plasma Cell Myeloma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.0556
p.V1062M	SIDM00232	Kidney Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.0556
p.V1062M	SIDM00577	Neuroblastoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.0556
p.V1062M	SIDM00315	Glioblastoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.0556
p.V1062M	SIDM00040	Gastric Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.0556
p.V1062M	SIDM00619	Thyroid Gland Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.0556
p.V1062M	SIDM00549	B-Lymphoblastic Leukemia	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.0556
p.V1062M	SIDM01658	Unknown	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.0556
p.D1085E	DO228952	LICA	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.1111
p.A1081E	DO228952	LICA	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2222
p.A1081E	DO229018	LICA	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2222
p.P1067T	DO229015	LICA	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.1944
p.P979H	DO229028	LICA	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation altering degron motif	0.7694
p.P1066T	DO229031	LICA	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.1667
p.P972L	DO50956	LICA	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation rewiring degron network	0.25
p.D1079E	DO229234	THCA	ICGC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2778
p.P1073T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation altering degron motif	0.5919
p.P1073T	ACH-002272	Lymphoma	CCLE	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation altering degron motif	0.5919
p.P1073T	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation altering degron motif	0.5919
p.S1076Y	SIDM00953	Small Cell Lung Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation altering degron motif	0.6009
p.S1076Y	SIDM00092	Ovarian Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation altering degron motif	0.6009
p.S1076Y	SIDM00310	Mesothelioma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation altering degron motif	0.6009
p.F192I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1944
p.F192I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1944
p.F209V	SIDM00889	Cervical Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1111
p.F209V	ACH-001333	Cervical Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1111
p.F209V	C-33-A	cervix	COSMIC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1111
p.H977D	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation altering degron motif	0.6577
p.H977D	SIDM00861	Ovarian Carcinoma	GDSC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation altering degron motif	0.6577
p.H977D	ES-2	ovary	COSMIC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation altering degron motif	0.6577
p.H977D	NCI-H1563	lung	COSMIC	PRHTPVCS	DEG_SCF_FBW7_1	975:982	Mutation altering degron motif	0.6577
p.V1072M	SIDM00542	Glioblastoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation altering degron motif	0.6097
p.V1072M	D-392MG	central nervous system	COSMIC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation altering degron motif	0.6097
p.E1065Q	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.1389
p.E1065Q	ACH-000951	Lung Cancer	CCLE	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.1389
p.E1065Q	NCI-H2342	lung	COSMIC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.1389
p.P1067L	SIDM00217	Colorectal Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.1944
p.P1067L	SNU-1040	large intestine	COSMIC	VPMYSD	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.1944
p.V197L	SIDM01229	Neuroblastoma	GDSC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.6765
p.V197L	BE2-M17	autonomic ganglia	COSMIC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.6765
p.S193P	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCM3AP

UniProt ID: O60318

Entrez ID: 8888

Protein name: Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCM3AP in