DegronMD

Uniprot ID: O60318

Source protein: Germinal-center associated nuclear protein

Source gene: MCM3AP

Class: DEG_SCF_FBW7_1

Location: 975:982

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 80.5

COIL: 0.8311

CONS_SCORE: 0.2955

DSS_SCORE: 0.451

HELIX: 0.0209

FCONS_SCORE: 0.8588

RIG_SCORE: 0.7608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N987Y	TCGA-B0-4811	KIRC	TCGA	PRHTPVCS	DEG_SCF_FBW7_1	0.1944
p.N987Y	DO17552	KIRC	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	0.1944
p.Y989H	TCGA-BR-4361	STAD	TCGA	PRHTPVCS	DEG_SCF_FBW7_1	0.1389
p.Y989H	DO38887	STAD	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	0.1389
p.V974A	TCGA-KO-8410	KICH	TCGA	PRHTPVCS	DEG_SCF_FBW7_1	0.3056
p.V974A	DO220572	KICH	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	0.3056
p.K988R	TCGA-XF-AAML	BLCA	TCGA	PRHTPVCS	DEG_SCF_FBW7_1	0.2778
p.K988R	DO51933	BLCA	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	0.2778
p.C981Y	DO222867	BTCA	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	0.5976
p.P979H	DO229028	LICA	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	0.7694
p.P972L	DO50956	LICA	ICGC	PRHTPVCS	DEG_SCF_FBW7_1	0.25
p.H977D	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PRHTPVCS	DEG_SCF_FBW7_1	0.6577
p.H977D	SIDM00861	Ovarian Carcinoma	GDSC	PRHTPVCS	DEG_SCF_FBW7_1	0.6577
p.H977D	ES-2	ovary	COSMIC	PRHTPVCS	DEG_SCF_FBW7_1	0.6577
p.H977D	NCI-H1563	lung	COSMIC	PRHTPVCS	DEG_SCF_FBW7_1	0.6577

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60318	Germinal-center associated nuclear protein	DEG_SCF_FBW7_1	975:982	PRHTPVCS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons