DegronMD

Uniprot ID: O60318

Source protein: Germinal-center associated nuclear protein

Source gene: MCM3AP

Class: LIG_APCC_ABBA_1

Location: 1072:1077

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9921

ASA_SCORE: 74.9

COIL: 0.7967

CONS_SCORE: 0.2883

DSS_SCORE: 0.7104

HELIX: 0.1678

FCONS_SCORE: 1.0371

RIG_SCORE: 0.6973

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1081V	TCGA-19-5956	GBM	TCGA	VPMYSD	LIG_APCC_ABBA_1	0.2222
p.A1081V	DO13863	GBM	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.2222
p.A1081V	DO227905	PBCA	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.2222
p.A1081V	DO229542	UTCA	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.2222
p.E1078K	TCGA-39-5031	LUSC	TCGA	VPMYSD	LIG_APCC_ABBA_1	0.3056
p.E1078K	TCGA-FD-A43P	BLCA	TCGA	VPMYSD	LIG_APCC_ABBA_1	0.3056
p.E1078K	TCGA-IB-7651	PAAD	TCGA	VPMYSD	LIG_APCC_ABBA_1	0.3056
p.E1078K	DO44049	BLCA	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.3056
p.E1078K	DO26526	LUSC	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.3056
p.E1078K	DO46657	PAAD	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.3056
p.P1069A	TCGA-AA-3715	COAD	TCGA	VPMYSD	LIG_APCC_ABBA_1	0.25
p.P1069A	DO8018	COAD	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.25
p.P1068S	TCGA-AA-3715	COAD	TCGA	VPMYSD	LIG_APCC_ABBA_1	0.2222
p.P1068S	DO8018	COAD	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.2222
p.V1062M	DO229346	LAML	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.0556
p.V1062M	SIDM00434	Plasma Cell Myeloma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.0556
p.V1062M	SIDM00232	Kidney Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.0556
p.V1062M	SIDM00577	Neuroblastoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.0556
p.V1062M	SIDM00315	Glioblastoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.0556
p.V1062M	SIDM00040	Gastric Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.0556
p.V1062M	SIDM00619	Thyroid Gland Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.0556
p.V1062M	SIDM00549	B-Lymphoblastic Leukemia	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.0556
p.V1062M	SIDM01658	Unknown	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.0556
p.D1085E	DO228952	LICA	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.1111
p.A1081E	DO228952	LICA	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.2222
p.A1081E	DO229018	LICA	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.2222
p.P1067T	DO229015	LICA	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.1944
p.P1066T	DO229031	LICA	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.1667
p.D1079E	DO229234	THCA	ICGC	VPMYSD	LIG_APCC_ABBA_1	0.2778
p.P1073T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.5919
p.P1073T	ACH-002272	Lymphoma	CCLE	VPMYSD	LIG_APCC_ABBA_1	0.5919
p.P1073T	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPMYSD	LIG_APCC_ABBA_1	0.5919
p.S1076Y	SIDM00953	Small Cell Lung Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.6009
p.S1076Y	SIDM00092	Ovarian Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.6009
p.S1076Y	SIDM00310	Mesothelioma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.6009
p.V1072M	SIDM00542	Glioblastoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.6097
p.V1072M	D-392MG	central_nervous_system	COSMIC	VPMYSD	LIG_APCC_ABBA_1	0.6097
p.E1065Q	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.1389
p.E1065Q	ACH-000951	Lung Cancer	CCLE	VPMYSD	LIG_APCC_ABBA_1	0.1389
p.E1065Q	NCI-H2342	lung	COSMIC	VPMYSD	LIG_APCC_ABBA_1	0.1389
p.P1067L	SIDM00217	Colorectal Carcinoma	GDSC	VPMYSD	LIG_APCC_ABBA_1	0.1944
p.P1067L	SNU-1040	large_intestine	COSMIC	VPMYSD	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPMYSD

Degron related mutations and impact score

Drug responses associated with MCM3AP mutations

All proteins holding degron of VPMYSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60318	Germinal-center associated nuclear protein	LIG_APCC_ABBA_1	1072:1077	VPMYSD	APC,CDC20,FZR1	0.9921	More...