DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11046:11050

E3 ligase: SPOP

DEGRON score: 0.9225

ASA_SCORE: 86.5

COIL: 0.92

CONS_SCORE: 0

DSS_SCORE: 0.4251

HELIX: 0.0132

FCONS_SCORE: 0

RIG_SCORE: 0.7034

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S11054G	TCGA-2G-AAEX	TGCT	TCGA	VTSSS	DEG_SPOP_SBC_1	0.2222
p.V11041M	TCGA-61-2095	OV	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1944
p.V11041M	DO234304	ESAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.V11041M	DO27987	OV	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.S11054N	TCGA-AG-A002	READ	TCGA	VTSSS	DEG_SPOP_SBC_1	0.2222
p.G11040R	TCGA-BF-AAP4	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1667
p.G11040R	DO219468	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.G11040R	SIDM00188	Kidney Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.G11040R	ACH-002139	Kidney Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.1667
p.G11040R	HA7-RCC	kidney	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.S11056I	TCGA-CV-7104	HNSC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1667
p.S11056I	DO14798	HNSC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.G11040E	TCGA-EE-A29T	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1667
p.G11040E	DO37742	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.G11051V	TCGA-EE-A29X	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	0.3056
p.G11051V	DO37595	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	0.3056
p.P11058L	TCGA-ER-A19G	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1111
p.P11058L	DO47284	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1111
p.L11045V	TCGA-FD-A6TB	BLCA	TCGA	VTSSS	DEG_SPOP_SBC_1	0.3056
p.L11045V	DO51879	BLCA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.3056
p.V11041L	TCGA-FX-A2QS	SARC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1944
p.V11041L	DO220116	SARC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.S11056R	DO223542	CLLE	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.S11056G	DO234212	ESAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.T11055K	DO228981	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.P11058T	DO50924	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1111
p.V11042L	DO231049	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.2222
p.S11050G	SIDM01119	Other Solid Cancers	GDSC	VTSSS	DEG_SPOP_SBC_1	0.6993
p.S11050G	ACH-000775	Lung Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.6993
p.S11050G	NCI-H727	lung	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.6993
p.S11056C	SIDM01056	Breast Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.S11056C	ACH-000330	Breast Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.1667
p.S11056C	EFM-19	breast	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.V11052L	SIDM01133	Other Solid Cancers	GDSC	VTSSS	DEG_SPOP_SBC_1	0.2778
p.V11052L	ACH-002177	Lung Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.2778
p.V11052L	NCI-H835	lung	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.2778
p.S11050I	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.7341
p.S11050I	ACH-000888	Lung Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.7341
p.S11050I	NCI-H1793	lung	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.7341
p.V11038A	LNCaP-Clone-FGC	prostate	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60318	Germinal-center associated nuclear protein	DEG_SPOP_SBC_1	197:201	VTSSS	SPOP	0.938	More...
P02533	Keratin, type I cytoskeletal 14	DEG_SPOP_SBC_1	441:445	VTSSS	SPOP	0.9845	More...
P15056	Serine/threonine-protein kinase B-raf	DEG_SPOP_SBC_1	120:124	VTSSS	SPOP	0.9734	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	207:211	VTSSS	SPOP	0.9601	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	2008:2012	VTSSS	SPOP	0.9659	More...
Q14161	ARF GTPase-activating protein GIT2	DEG_SPOP_SBC_1	554:558	VTSSS	SPOP	0.9992	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	3641:3645	VTSSS	SPOP	0.8527	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3548:3552	VTSSS	SPOP	0.9001	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	442:446	VTSSS	SPOP	0.9354	More...
Q8IY22	C-Maf-inducing protein	DEG_SPOP_SBC_1	3:7	VTSSS	SPOP	0.9749	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	108:112	VTSSS	SPOP	0.9792	More...
Q8TF40	Folliculin-interacting protein 1	DEG_SPOP_SBC_1	104:108	VTSSS	SPOP	0.9551	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3897:3901	VTSSS	SPOP	0.9951	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4932:4936	VTSSS	SPOP	0.8363	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7283:7287	VTSSS	SPOP	0.9977	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8158:8162	VTSSS	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11046:11050	VTSSS	SPOP	0.9225	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	565:569	VTSSS	SPOP	0.9982	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1615:1619	VTSSS	SPOP	0.8983	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	965:969	VTSSS	SPOP	0.9734	More...
A6NNH2	Protein FAM90A27P	DEG_SPOP_SBC_1	449:453	VTSSS	SPOP	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VTSSS