DegronMD - Q9UPP1(PHF8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R894C	TCGA-2W-A8YY	CESC	TCGA	SPKARVTPT	DEG_SIAH_1	880:888	Mutation rewiring degron network	0.1667
p.P878T	TCGA-36-2548	OV	TCGA	SPKARVTPT	DEG_SIAH_1	880:888	Mutation rewiring degron network	0.2778
p.S777C	TCGA-55-7570	LUAD	TCGA	PATSS	DEG_SPOP_SBC_1	774:778	Mutation altering degron motif	0.7541
p.S522F	TCGA-56-7822	LUSC	TCGA	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation blocking phosphorylation signal	0.5
p.S522F	TCGA-BF-A5ES	SKCM	TCGA	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation blocking phosphorylation signal	0.5
p.S771L	TCGA-90-A4ED	LUSC	TCGA	PATSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.25
p.S771L	TCGA-EK-A3GK	CESC	TCGA	PATSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.25
p.T957P	TCGA-AA-3846	COAD	TCGA	VTSSS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.1111
p.S968F	TCGA-B5-A1MX	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	965:969	Mutation altering degron motif	0.7982
p.P887Q	TCGA-BF-A1PZ	SKCM	TCGA	SPKARVTPT	DEG_SIAH_1	880:888	Mutation altering degron motif	0.7035
p.P887Q	TCGA-ER-A19B	SKCM	TCGA	SPKARVTPT	DEG_SIAH_1	880:888	Mutation altering degron motif	0.7035
p.H509N	TCGA-BF-A1Q0	SKCM	TCGA	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6312
p.P890L	TCGA-BK-A6W3	UCEC	TCGA	SPKARVTPT	DEG_SIAH_1	880:888	Mutation rewiring degron network	0.2778
p.P970L	TCGA-EE-A3AG	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.3056
p.R897H	TCGA-EY-A1GK	UCEC	TCGA	SPKARVTPT	DEG_SIAH_1	880:888	Mutation rewiring degron network	0.0833
p.A513T	DO3524	BRCA	ICGC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.3056
p.A780T	DO229010	COCA	ICGC	PATSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.2778
p.P962Q	DO229026	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.25
p.P958H	DO229032	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.1389
p.A956D	DO229045	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.0833
p.D876V	DO23136	LINC	ICGC	SPKARVTPT	DEG_SIAH_1	880:888	Mutation rewiring degron network	0.2222
p.R765Q	DO24507	LUAD	ICGC	PATSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0833
p.R506L	DO51192	LUAD	ICGC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.2778
p.A504P	DO27453	LUSC	ICGC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.2222
p.E499K	DO222536	MELA	ICGC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.0833
p.E499K	DO218850	SKCA	ICGC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.0833
p.E499K	DO229227	THCA	ICGC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.0833
p.R506Q	DO47636	SKCM	ICGC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.2778
p.G976R	DO229259	THCA	ICGC	VTSSS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.1389
p.E772K	DO43578	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.2778
p.E772K	DO42793	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.2778
p.P878Q	SIDM00541	Colorectal Carcinoma	GDSC	SPKARVTPT	DEG_SIAH_1	880:888	Mutation rewiring degron network	0.2778
p.P878Q	HT55	large intestine	COSMIC	SPKARVTPT	DEG_SIAH_1	880:888	Mutation rewiring degron network	0.2778
p.R517K	SIDM00845	Burkitt's Lymphoma	GDSC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1944
p.R517K	Daudi	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1944
p.R884L	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	SPKARVTPT	DEG_SIAH_1	880:888	Mutation altering degron motif	0.7316
p.R884L	NCI-H1437	lung	COSMIC	SPKARVTPT	DEG_SIAH_1	880:888	Mutation altering degron motif	0.7316
p.E510Q	ACH-000786	Lymphoma	CCLE	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6744
p.E510Q	ACH-000992	Head and Neck Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6744
p.E510Q	ACH-001067	Brain Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6744
p.E510Q	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6744
p.E510Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6744
p.L500I	ACH-000786	Lymphoma	CCLE	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1111
p.L500I	ACH-000992	Head and Neck Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1111
p.L500I	ACH-001067	Brain Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1111
p.L500I	Daudi	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1111
p.L500I	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1111
p.L500I	DND-41	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1111
p.E499D	ACH-000786	Lymphoma	CCLE	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.0833
p.E499D	ACH-000992	Head and Neck Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.0833
p.E499D	DND-41	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.0833
p.E499D	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.0833
p.E499D	Daudi	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.0833
p.R506K	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.2778
p.R506K	Daudi	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.2778

Kaplan plot for PHF8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHF8

UniProt ID: Q9UPP1

Entrez ID: 23133

Protein name: Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHF8 in