DegronMD

Uniprot ID: Q9UPP1

Source protein: Histone lysine demethylase PHF8

Source gene: PHF8

Class: DEG_SIAH_1

Location: 880:888

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9627

ASA_SCORE: 93.4333

COIL: 0.9013

CONS_SCORE: 0.3745

DSS_SCORE: 0.682

HELIX: 0.055

FCONS_SCORE: 1.0838

RIG_SCORE: 0.6759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R894C	TCGA-2W-A8YY	CESC	TCGA	SPKARVTPT	DEG_SIAH_1	0.1667
p.P878T	TCGA-36-2548	OV	TCGA	SPKARVTPT	DEG_SIAH_1	0.2778
p.P887Q	TCGA-BF-A1PZ	SKCM	TCGA	SPKARVTPT	DEG_SIAH_1	0.7035
p.P887Q	TCGA-ER-A19B	SKCM	TCGA	SPKARVTPT	DEG_SIAH_1	0.7035
p.P890L	TCGA-BK-A6W3	UCEC	TCGA	SPKARVTPT	DEG_SIAH_1	0.2778
p.R897H	TCGA-EY-A1GK	UCEC	TCGA	SPKARVTPT	DEG_SIAH_1	0.0833
p.D876V	DO23136	LINC	ICGC	SPKARVTPT	DEG_SIAH_1	0.2222
p.P878Q	SIDM00541	Colorectal Carcinoma	GDSC	SPKARVTPT	DEG_SIAH_1	0.2778
p.P878Q	HT55	large_intestine	COSMIC	SPKARVTPT	DEG_SIAH_1	0.2778
p.R884L	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	SPKARVTPT	DEG_SIAH_1	0.7316
p.R884L	NCI-H1437	lung	COSMIC	SPKARVTPT	DEG_SIAH_1	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPP1	Histone lysine demethylase PHF8	DEG_SIAH_1	880:888	SPKARVTPT	SIAH1,SIAH2,SIAH3	0.9627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons