DegronMD

Uniprot ID: Q9UPP1

Source protein: Histone lysine demethylase PHF8

Source gene: PHF8

Class: DEG_SPOP_SBC_1

Location: 508:512

E3 ligase: SPOP

DEGRON score: 0.997

ASA_SCORE: 81.94

COIL: 0.8808

CONS_SCORE: 0.3227

DSS_SCORE: 0.4777

HELIX: 0.0762

FCONS_SCORE: 1.0971

RIG_SCORE: 0.6819

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S522F	TCGA-56-7822	LUSC	TCGA	AHSTS	DEG_SPOP_SBC_1	0.5
p.S522F	TCGA-BF-A5ES	SKCM	TCGA	AHSTS	DEG_SPOP_SBC_1	0.5
p.H509N	TCGA-BF-A1Q0	SKCM	TCGA	AHSTS	DEG_SPOP_SBC_1	0.6312
p.A513T	DO3524	BRCA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.3056
p.R506L	DO51192	LUAD	ICGC	AHSTS	DEG_SPOP_SBC_1	0.2778
p.A504P	DO27453	LUSC	ICGC	AHSTS	DEG_SPOP_SBC_1	0.2222
p.E499K	DO222536	MELA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.E499K	DO218850	SKCA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.E499K	DO229227	THCA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.R506Q	DO47636	SKCM	ICGC	AHSTS	DEG_SPOP_SBC_1	0.2778
p.R517K	SIDM00845	Burkitt's Lymphoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.1944
p.R517K	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.1944
p.E510Q	ACH-000786	Lymphoma	CCLE	AHSTS	DEG_SPOP_SBC_1	0.6744
p.E510Q	ACH-000992	Head and Neck Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.6744
p.E510Q	ACH-001067	Brain Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.6744
p.E510Q	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.6744
p.E510Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.6744
p.L500I	ACH-000786	Lymphoma	CCLE	AHSTS	DEG_SPOP_SBC_1	0.1111
p.L500I	ACH-000992	Head and Neck Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.1111
p.L500I	ACH-001067	Brain Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.1111
p.L500I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.1111
p.L500I	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.1111
p.L500I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.1111
p.E499D	ACH-000786	Lymphoma	CCLE	AHSTS	DEG_SPOP_SBC_1	0.0833
p.E499D	ACH-000992	Head and Neck Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.0833
p.E499D	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.E499D	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.E499D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.R506K	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.2778
p.R506K	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12816	Trophinin	DEG_SPOP_SBC_1	798:802	AHSTS	SPOP	0.7651	More...
Q58WW2	DDB1- and CUL4-associated factor 6	DEG_SPOP_SBC_1	421:425	AHSTS	SPOP	0.5333	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	404:408	AHSTS	SPOP	0.5117	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	895:899	AHSTS	SPOP	0.9976	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	508:512	AHSTS	SPOP	0.997	More...
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	1230:1234	AHSTS	SPOP	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AHSTS

Degron related mutations and impact score

Drug responses associated with PHF8 mutations

All proteins holding degron of AHSTS