DegronMD - Q58WW2(DCAF6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S414F	TCGA-AP-A0LM	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7982
p.S414F	DO43306	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7982
p.Q420H	TCGA-BF-A1Q0	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.Q420H	TCGA-BF-A1Q0	SKCM	TCGA	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.3056
p.Q420H	DO47374	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.Q420H	DO47374	SKCM	ICGC	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.3056
p.S415F	TCGA-C5-A1MK	CESC	TCGA	PSTSS	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7982
p.S415F	DO6290	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7982
p.Q420E	TCGA-C5-A1MN	CESC	TCGA	PSTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.Q420E	TCGA-C5-A1MN	CESC	TCGA	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.3056
p.Q420E	TCGA-D8-A1JA	BRCA	TCGA	PSTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.Q420E	TCGA-D8-A1JA	BRCA	TCGA	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.3056
p.Q420E	DO2819	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.Q420E	DO2819	BRCA	ICGC	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.3056
p.Q420E	DO6257	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.Q420E	DO6257	CESC	ICGC	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.3056
p.S433F	TCGA-EE-A29B	SKCM	TCGA	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1111
p.S433F	DO47255	SKCM	ICGC	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1111
p.H422R	DO228920	LICA	ICGC	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation altering degron motif	0.7133
p.E429K	DO229542	UTCA	ICGC	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.2222
p.T434I	ACH-001061	Colon/Colorectal Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0833

Kaplan plot for DCAF6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCAF6

UniProt ID: Q58WW2

Entrez ID: 55827

Protein name: DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCAF6 in