DegronMD

Uniprot ID: Q12816

Source protein: Trophinin

Source gene: TRO

Class: DEG_SPOP_SBC_1

Location: 798:802

E3 ligase: SPOP

DEGRON score: 0.7651

ASA_SCORE: 81.36

COIL: 0.7822

CONS_SCORE: 0.6042

DSS_SCORE: 0.1577

HELIX: 0.0562

FCONS_SCORE: 1.2389

RIG_SCORE: 0.7133

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S800I	TCGA-2Y-A9GZ	LIHC	TCGA	AHSTS	DEG_SPOP_SBC_1	0.7341
p.S800I	TCGA-AX-A06F	UCEC	TCGA	AHSTS	DEG_SPOP_SBC_1	0.7341
p.S788G	TCGA-BR-4368	STAD	TCGA	AHSTS	DEG_SPOP_SBC_1	0.0556
p.S788G	DO38715	STAD	ICGC	AHSTS	DEG_SPOP_SBC_1	0.0556
p.T798P	DO11166	GBM	ICGC	AHSTS	DEG_SPOP_SBC_1	0.7031
p.G796V	DO228978	LICA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.2778
p.S807R	DO24070	LUAD	ICGC	AHSTS	DEG_SPOP_SBC_1	0.1944
p.S812I	DO46488	OV	ICGC	AHSTS	DEG_SPOP_SBC_1	0.0556
p.D792E	DO229453	SKCA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.1667
p.H799P	SIDM00656	Burkitt's Lymphoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.6583
p.H799P	SIDM00087	Plasma Cell Myeloma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.6583
p.H799P	SIDM00863	Burkitt's Lymphoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.6583
p.H799P	SIDM00720	Mesothelioma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.6583
p.H799P	SIDM00785	Acute Myeloid Leukemia	GDSC	AHSTS	DEG_SPOP_SBC_1	0.6583
p.H799P	SIDM00641	Burkitt's Lymphoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.6583
p.H799P	SIDM01640	Acute Myeloid Leukemia	GDSC	AHSTS	DEG_SPOP_SBC_1	0.6583
p.S806I	SIDM00687	Gastric Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.2222
p.S806I	ACH-000793	Gastric Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.2222
p.S806I	KATOIII	stomach	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.2222
p.S800N	SIDM01617	Endometrial Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.7069
p.S800N	ACH-000994	Endometrial/Uterine Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.7069
p.A791T	ACH-001991	Primary	CCLE	AHSTS	DEG_SPOP_SBC_1	0.1389
p.L804M	NCI-H1417	lung	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.2778
p.T806I	SW1271	lung	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.2222
p.G793V	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12816	Trophinin	DEG_SPOP_SBC_1	798:802	AHSTS	SPOP	0.7651	More...
Q58WW2	DDB1- and CUL4-associated factor 6	DEG_SPOP_SBC_1	421:425	AHSTS	SPOP	0.5333	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	404:408	AHSTS	SPOP	0.5117	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	895:899	AHSTS	SPOP	0.9976	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	508:512	AHSTS	SPOP	0.997	More...
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	1230:1234	AHSTS	SPOP	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AHSTS

Degron related mutations and impact score

Drug responses associated with TRO mutations

All proteins holding degron of AHSTS