DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VTSSS
Uniprot ID:
A6NNH2
Source protein:
Protein FAM90A27P
Source gene:
FAM90A27P
Class:
DEG_SPOP_SBC_1
Location:
449:453
E3 ligase:
SPOP
DEGRON score:
0.9881
ASA_SCORE:
67.58
COIL:
0.7778
CONS_SCORE:
0.7007
DSS_SCORE:
0.7117
HELIX:
0.0314
FCONS_SCORE:
1.1695
RIG_SCORE:
0.6901
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM90A27P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60318
Germinal-center associated nuclear protein
DEG_SPOP_SBC_1
197:201
VTSSS
SPOP
0.938
More...
P02533
Keratin, type I cytoskeletal 14
DEG_SPOP_SBC_1
441:445
VTSSS
SPOP
0.9845
More...
P15056
Serine/threonine-protein kinase B-raf
DEG_SPOP_SBC_1
120:124
VTSSS
SPOP
0.9734
More...
P19484
Transcription factor EB
DEG_SPOP_SBC_1
207:211
VTSSS
SPOP
0.9601
More...
Q14008
Cytoskeleton-associated protein 5
DEG_SPOP_SBC_1
2008:2012
VTSSS
SPOP
0.9659
More...
Q14161
ARF GTPase-activating protein GIT2
DEG_SPOP_SBC_1
554:558
VTSSS
SPOP
0.9992
More...
Q15911
Zinc finger homeobox protein 3
DEG_SPOP_SBC_1
3641:3645
VTSSS
SPOP
0.8527
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3548:3552
VTSSS
SPOP
0.9001
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
442:446
VTSSS
SPOP
0.9354
More...
Q8IY22
C-Maf-inducing protein
DEG_SPOP_SBC_1
3:7
VTSSS
SPOP
0.9749
More...
Q8TBK6
Zinc finger CCHC domain-containing protein 10
DEG_SPOP_SBC_1
108:112
VTSSS
SPOP
0.9792
More...
Q8TF40
Folliculin-interacting protein 1
DEG_SPOP_SBC_1
104:108
VTSSS
SPOP
0.9551
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
3897:3901
VTSSS
SPOP
0.9951
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
4932:4936
VTSSS
SPOP
0.8363
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
7283:7287
VTSSS
SPOP
0.9977
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
8158:8162
VTSSS
SPOP
0.9995
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
11046:11050
VTSSS
SPOP
0.9225
More...
Q92622
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
DEG_SPOP_SBC_1
565:569
VTSSS
SPOP
0.9982
More...
Q9ULT8
E3 ubiquitin-protein ligase HECTD1
DEG_SPOP_SBC_1
1615:1619
VTSSS
SPOP
0.8983
More...
Q9UPP1
Histone lysine demethylase PHF8
DEG_SPOP_SBC_1
965:969
VTSSS
SPOP
0.9734
More...
A6NNH2
Protein FAM90A27P
DEG_SPOP_SBC_1
449:453
VTSSS
SPOP
0.9881
More...