DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 8158:8162

E3 ligase: SPOP

DEGRON score: 0.9995

ASA_SCORE: 80.3

COIL: 0.843

CONS_SCORE: 0

DSS_SCORE: 0.4825

HELIX: 0.025

FCONS_SCORE: 0

RIG_SCORE: 0.7147

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L8172I	TCGA-05-4249	LUAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.0556
p.L8172I	DO23891	LUAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.0556
p.T8159A	TCGA-95-7567	LUAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.7139
p.T8159A	DO25564	LUAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.7139
p.A8151T	TCGA-AA-3845	COAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1389
p.A8151T	DO10020	COAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.E8152K	TCGA-BF-AAP0	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1667
p.E8152K	DO219462	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.E8152D	TCGA-BR-8680	STAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1667
p.E8152D	TCGA-D7-6528	STAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.1667
p.E8152D	DO38547	STAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.E8152D	DO47769	STAD	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1667
p.R8155M	TCGA-CN-4739	HNSC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.25
p.R8155M	DO14478	HNSC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.25
p.V8158F	TCGA-CV-5978	HNSC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.7068
p.V8158F	DO16023	HNSC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.7068
p.R8155K	TCGA-D3-A5GU	SKCM	TCGA	VTSSS	DEG_SPOP_SBC_1	0.25
p.R8155K	DO47584	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	0.25
p.S8161C	TCGA-J1-A4AH	LUSC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.7541
p.S8161C	DO45479	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.7541
p.A8170S	DO48296	ESCA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1111
p.I8166V	DO32980	PACA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.2222
p.G8148D	DO51470	PACA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.0556
p.S8154F	SIDM00545	Melanoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.2222
p.S8154F	ACH-000987	Skin Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.2222
p.S8154F	Mewo	skin	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.2222
p.S8160F	SIDM00853	Other Sarcomas	GDSC	VTSSS	DEG_SPOP_SBC_1	0.9093
p.S8160F	ACH-000835	Sarcoma	CCLE	VTSSS	DEG_SPOP_SBC_1	0.9093
p.S8160F	GCT	soft_tissue	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.9093
p.Q8171H	ACH-000941	Endometrial/Uterine Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60318	Germinal-center associated nuclear protein	DEG_SPOP_SBC_1	197:201	VTSSS	SPOP	0.938	More...
P02533	Keratin, type I cytoskeletal 14	DEG_SPOP_SBC_1	441:445	VTSSS	SPOP	0.9845	More...
P15056	Serine/threonine-protein kinase B-raf	DEG_SPOP_SBC_1	120:124	VTSSS	SPOP	0.9734	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	207:211	VTSSS	SPOP	0.9601	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	2008:2012	VTSSS	SPOP	0.9659	More...
Q14161	ARF GTPase-activating protein GIT2	DEG_SPOP_SBC_1	554:558	VTSSS	SPOP	0.9992	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	3641:3645	VTSSS	SPOP	0.8527	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3548:3552	VTSSS	SPOP	0.9001	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	442:446	VTSSS	SPOP	0.9354	More...
Q8IY22	C-Maf-inducing protein	DEG_SPOP_SBC_1	3:7	VTSSS	SPOP	0.9749	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	108:112	VTSSS	SPOP	0.9792	More...
Q8TF40	Folliculin-interacting protein 1	DEG_SPOP_SBC_1	104:108	VTSSS	SPOP	0.9551	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3897:3901	VTSSS	SPOP	0.9951	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4932:4936	VTSSS	SPOP	0.8363	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7283:7287	VTSSS	SPOP	0.9977	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8158:8162	VTSSS	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11046:11050	VTSSS	SPOP	0.9225	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	565:569	VTSSS	SPOP	0.9982	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1615:1619	VTSSS	SPOP	0.8983	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	965:969	VTSSS	SPOP	0.9734	More...
A6NNH2	Protein FAM90A27P	DEG_SPOP_SBC_1	449:453	VTSSS	SPOP	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VTSSS