DegronMD

Uniprot ID: P19484

Source protein: Transcription factor EB

Source gene: TFEB

Class: DEG_SPOP_SBC_1

Location: 207:211

E3 ligase: SPOP

DEGRON score: 0.9601

ASA_SCORE: 72.8

COIL: 0.9082

CONS_SCORE: 0.7014

DSS_SCORE: 0.4167

HELIX: 0.0342

FCONS_SCORE: 1.0206

RIG_SCORE: 0.6964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L204M	TCGA-86-7701	LUAD	TCGA	VTSSS	DEG_SPOP_SBC_1	0.25
p.R220Q	TCGA-CV-5966	HNSC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.0833
p.R220Q	DO14950	HNSC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.0833
p.A214V	TCGA-DD-A3A2	LIHC	TCGA	VTSSS	DEG_SPOP_SBC_1	0.25
p.A214V	DO44881	LIHC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.25
p.S211Y	TCGA-FD-A6TC	BLCA	TCGA	VTSSS	DEG_SPOP_SBC_1	0.8231
p.S211F	DO52699	CLLE	ICGC	VTSSS	DEG_SPOP_SBC_1	0.9093
p.S211F	DO10809	EOPC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.9093
p.R218H	DO228935	COCA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1389
p.S210F	DO224628	COCA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.7982
p.D215E	DO229041	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.2222
p.H216D	DO23456	LINC	ICGC	VTSSS	DEG_SPOP_SBC_1	0.1944
p.T208A	DO229213	THCA	ICGC	VTSSS	DEG_SPOP_SBC_1	0.6028
p.V221I	SIDM01144	Gastric Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.0556
p.V221I	NCI-SNU-5	stomach	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.0556
p.G220S	SIDM01228	Melanoma	GDSC	VTSSS	DEG_SPOP_SBC_1	0.0833
p.G220S	CHL-1	skin	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.0833
p.P212A	SIDM01691	Chronic Myelogenous Leukemia	GDSC	VTSSS	DEG_SPOP_SBC_1	0.3056
p.S209N	ACH-000922	Leukemia	CCLE	VTSSS	DEG_SPOP_SBC_1	0.7069
p.G206S	ACH-000931	Skin Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.3056
p.G206S	ACH-001024	Skin Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	0.3056
p.G206S	CHL-1	skin	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.3056
p.V207I	NCI-SNU-5	stomach	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.7076
p.M203I	Hs766T	pancreas	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.2222
p.H216R	IST-SL1	lung	COSMIC	VTSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60318	Germinal-center associated nuclear protein	DEG_SPOP_SBC_1	197:201	VTSSS	SPOP	0.938	More...
P02533	Keratin, type I cytoskeletal 14	DEG_SPOP_SBC_1	441:445	VTSSS	SPOP	0.9845	More...
P15056	Serine/threonine-protein kinase B-raf	DEG_SPOP_SBC_1	120:124	VTSSS	SPOP	0.9734	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	207:211	VTSSS	SPOP	0.9601	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	2008:2012	VTSSS	SPOP	0.9659	More...
Q14161	ARF GTPase-activating protein GIT2	DEG_SPOP_SBC_1	554:558	VTSSS	SPOP	0.9992	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	3641:3645	VTSSS	SPOP	0.8527	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3548:3552	VTSSS	SPOP	0.9001	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	442:446	VTSSS	SPOP	0.9354	More...
Q8IY22	C-Maf-inducing protein	DEG_SPOP_SBC_1	3:7	VTSSS	SPOP	0.9749	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	108:112	VTSSS	SPOP	0.9792	More...
Q8TF40	Folliculin-interacting protein 1	DEG_SPOP_SBC_1	104:108	VTSSS	SPOP	0.9551	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3897:3901	VTSSS	SPOP	0.9951	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4932:4936	VTSSS	SPOP	0.8363	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7283:7287	VTSSS	SPOP	0.9977	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8158:8162	VTSSS	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11046:11050	VTSSS	SPOP	0.9225	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	565:569	VTSSS	SPOP	0.9982	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1615:1619	VTSSS	SPOP	0.8983	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	965:969	VTSSS	SPOP	0.9734	More...
A6NNH2	Protein FAM90A27P	DEG_SPOP_SBC_1	449:453	VTSSS	SPOP	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSSS

Degron related mutations and impact score

Drug responses associated with TFEB mutations

All proteins holding degron of VTSSS