DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPEY
Uniprot ID:
Q15678
Source protein:
Tyrosine-protein phosphatase non-receptor type 14
Source gene:
PTPN14
Class:
ITCH
Location:
749:752
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9698
ASA_SCORE:
92.975
COIL:
0.9415
CONS_SCORE:
0.387
DSS_SCORE:
0.67
HELIX:
0.0158
FCONS_SCORE:
1.1168
RIG_SCORE:
0.5717
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y752C
SIDM00153
T-Lymphoblastic Leukemia
GDSC
PPEY
ITCH
0.7087
p.Y752C
ACH-000964
Leukemia
CCLE
PPEY
ITCH
0.7087
p.G754S
TCGA-FI-A2F4
UCEC
TCGA
PPEY
ITCH
0.2778
p.G754S
TCGA-KK-A59V
PRAD
TCGA
PPEY
ITCH
0.2778
p.G754S
DO51346
PRAD
ICGC
PPEY
ITCH
0.2778
p.G754S
DO43434
UCEC
ICGC
PPEY
ITCH
0.2778
p.R743H
DO233652
GACA
ICGC
PPEY
ITCH
0.1667
Showing 1 to 7 of 7 entries
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Drug responses associated with PTPN14 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPEY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q4VCS5
Angiomotin
ITCH
239:242
PPEY
ITCH,NEDD4
0.9966
More...
Q4VCS5
Angiomotin
ITCH
284:287
PPEY
ITCH,NEDD4
0.9928
More...
Q8IY63
Angiomotin-like protein 1
ITCH
310:313
PPEY
ITCH,NEDD4
0.9985
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Q8IY63
Angiomotin-like protein 1
ITCH
367:370
PPEY
ITCH,NEDD4
0.9955
More...
Q8N5I2
Arrestin domain-containing protein 1
ITCH
402:405
PPEY
ITCH,NEDD4
0.923
More...
Q8TBH0
Arrestin domain-containing protein 2
ITCH
339:342
PPEY
ITCH,NEDD4
0.9109
More...
Q5T5X7
BEN domain-containing protein 3
ITCH
243:246
PPEY
ITCH,NEDD4
0.9695
More...
Q58F21
Bromodomain testis-specific protein
ITCH
16:19
PPEY
ITCH,NEDD4
0.6067
More...
P20810
Calpastatin
ITCH
615:618
PPEY
ITCH,NEDD4
0.9885
More...
Q01850
Cerebellar degeneration-related protein 2
ITCH
419:422
PPEY
ITCH,NEDD4
0.9911
More...
O75153
Clustered mitochondria protein homolog
ITCH
186:189
PPEY
ITCH,NEDD4
0.9952
More...
Q14118
Dystroglycan 1
ITCH
828:831
PPEY
ITCH,NEDD4
0.9964
More...
Q12849
G-rich sequence factor 1
ITCH
132:135
PPEY
ITCH,NEDD4
0.7614
More...
O14964
Hepatocyte growth factor-regulated tyrosine kinase substrate
ITCH
234:237
PPEY
ITCH,NEDD4
0.9849
More...
Q03164
Histone-lysine N-methyltransferase 2A
ITCH
3788:3791
PPEY
ITCH,NEDD4
0.6997
More...
O15047
Histone-lysine N-methyltransferase SETD1A
ITCH
643:646
PPEY
ITCH,NEDD4
0.6336
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O43364
Homeobox protein Hox-A2
ITCH
92:95
PPEY
ITCH,NEDD4
0.9063
More...
Q15811
Intersectin-1
ITCH
300:303
PPEY
ITCH,NEDD4
0.9101
More...
Q9UBK8
Methionine synthase reductase
ITCH
246:249
PPEY
ITCH,NEDD4
0.9386
More...
Q9NRQ2
Phospholipid scramblase 4
ITCH
30:33
PPEY
ITCH,NEDD4
0.9894
More...
O60320
Protein FAM189A1
ITCH
251:254
PPEY
ITCH,NEDD4
0.909
More...
P81408
Protein FAM189B
ITCH
252:255
PPEY
ITCH,NEDD4
0.9827
More...
Q8WZ42
Titin
ITCH
14140:14143
PPEY
ITCH,NEDD4
0.8834
More...
Q8WZ42
Titin
ITCH
19345:19348
PPEY
ITCH,NEDD4
0.8515
More...
Q8WZ42
Titin
ITCH
26437:26440
PPEY
ITCH,NEDD4
0.6728
More...
Showing 1 to 25 of 28 entries
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