DegronMD - Q9UBK8(MTRR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S258L	TCGA-A7-A0CG	BRCA	TCGA	PPEY	ITCH	246:249	Mutation rewiring degron network	0.0833
p.S258L	TCGA-BF-AAP2	SKCM	TCGA	PPEY	ITCH	246:249	Mutation rewiring degron network	0.0833
p.S258L	DO5604	BRCA	ICGC	PPEY	ITCH	246:249	Mutation rewiring degron network	0.0833
p.S258L	DO219466	SKCM	ICGC	PPEY	ITCH	246:249	Mutation rewiring degron network	0.0833
p.S191R	TCGA-AO-A1KS	BRCA	TCGA	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.1389
p.S191R	DO1547	BRCA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.1389
p.S191R	DO231186	LUSC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.1389
p.N237Y	TCGA-AP-A059	UCEC	TCGA	PPEY	ITCH	246:249	Mutation rewiring degron network	0.0833
p.N237Y	DO41361	UCEC	ICGC	PPEY	ITCH	246:249	Mutation rewiring degron network	0.0833
p.A193T	TCGA-AP-A1DV	UCEC	TCGA	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.1944
p.A193T	DO43186	UCEC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.1944
p.V239M	TCGA-CM-5861	COAD	TCGA	PPEY	ITCH	246:249	Mutation rewiring degron network	0.1389
p.V239M	DO7918	COAD	ICGC	PPEY	ITCH	246:249	Mutation rewiring degron network	0.1389
p.N237S	TCGA-DI-A2QY	UCEC	TCGA	PPEY	ITCH	246:249	Mutation rewiring degron network	0.0833
p.N237S	DO42031	UCEC	ICGC	PPEY	ITCH	246:249	Mutation rewiring degron network	0.0833
p.R257H	TCGA-G4-6628	COAD	TCGA	PPEY	ITCH	246:249	Mutation rewiring degron network	0.1111
p.R257H	DO10132	COAD	ICGC	PPEY	ITCH	246:249	Mutation rewiring degron network	0.1111
p.R257H	SIDM02013	Colorectal Carcinoma	GDSC	PPEY	ITCH	246:249	Mutation rewiring degron network	0.1111
p.R257H	COR-L95	lung	COSMIC	PPEY	ITCH	246:249	Mutation rewiring degron network	0.1111
p.A200S	TCGA-UB-A7MB	LIHC	TCGA	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7588
p.A200S	DO52318	LIHC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7588
p.A193S	TCGA-VQ-AA6D	STAD	TCGA	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.1944
p.A193S	DO222392	STAD	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.1944
p.S202L	DO229010	COCA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.S202L	DO229016	COCA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.S202L	DO234285	ESAD	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.S202L	DO229353	LAML	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.S202L	DO230659	LAML	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.S202L	DO231140	LAML	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.S202L	DO228941	LICA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.S202L	DO228947	LICA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.S202L	DO230529	LUSC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.S202L	DO52365	LUSC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.S202L	DO231075	LUSC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation altering degron motif	0.7667
p.V196L	DO229008	LICA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.2778
p.I190V	DO44680	LICA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.1111
p.S253F	DO222837	MELA	ICGC	PPEY	ITCH	246:249	Mutation rewiring degron network	0.2222
p.K208E	SIDM01137	Pancreatic Carcinoma	GDSC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation blocking ubiquitination signal	0.6667
p.K208E	ACH-000235	Pancreatic Cancer	CCLE	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation blocking ubiquitination signal	0.6667
p.K208E	PANC-04-03	pancreas	COSMIC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation blocking ubiquitination signal	0.6667
p.E248Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	246:249	Mutation altering degron motif	0.5633
p.E248Q	ACH-002176	Lung Cancer	CCLE	PPEY	ITCH	246:249	Mutation altering degron motif	0.5633
p.E248Q	NCI-H748	lung	COSMIC	PPEY	ITCH	246:249	Mutation altering degron motif	0.5633
p.R195T	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.25
p.R195T	ACH-000809	Esophageal Cancer	CCLE	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.25
p.R195T	KYSE-410	oesophagus	COSMIC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.25
p.L207F	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.25
p.L207F	ACH-000544	Esophageal Cancer	CCLE	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.25
p.L207F	OE21	oesophagus	COSMIC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation rewiring degron network	0.25
p.S189C	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation blocking phosphorylation signal	0.5278
p.S189C	ACH-000353	Esophageal Cancer	CCLE	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation blocking phosphorylation signal	0.5278
p.S189C	TE-15	oesophagus	COSMIC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation blocking phosphorylation signal	0.5278
p.P247S	SIDM00808	Burkitt's Lymphoma	GDSC	PPEY	ITCH	246:249	Mutation altering degron motif	0.6752
p.P247S	SIDM01254	Burkitt's Lymphoma	GDSC	PPEY	ITCH	246:249	Mutation altering degron motif	0.6752
p.L250V	SIDM01611	Endometrial Carcinoma	GDSC	PPEY	ITCH	246:249	Mutation rewiring degron network	0.3056
p.L250V	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPEY	ITCH	246:249	Mutation rewiring degron network	0.3056
p.K208N	LS-411N	large intestine	COSMIC	DSGRKDS	DEG_SCF_TRCP1_1	198:204	Mutation blocking ubiquitination signal	0.6667

Kaplan plot for MTRR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTRR

UniProt ID: Q9UBK8

Entrez ID: 4552

Protein name: Methionine synthase reductase (MSR) (EC 1.16.1.8) (Aquacobalamin reductase) (AqCbl reductase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTRR in