DegronMD

Uniprot ID: Q9UBK8

Source protein: Methionine synthase reductase

Source gene: MTRR

Class: DEG_SCF_TRCP1_1

Location: 198:204

E3 ligase: BTRC

DEGRON score: 0.9908

ASA_SCORE: 77.2429

COIL: 0.7004

CONS_SCORE: 0.3201

DSS_SCORE: 0.3619

HELIX: 0.2563

FCONS_SCORE: 0.9876

RIG_SCORE: 0.7137

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S191R	TCGA-AO-A1KS	BRCA	TCGA	DSGRKDS	DEG_SCF_TRCP1_1	0.1389
p.S191R	DO1547	BRCA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.1389
p.S191R	DO231186	LUSC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.1389
p.A193T	TCGA-AP-A1DV	UCEC	TCGA	DSGRKDS	DEG_SCF_TRCP1_1	0.1944
p.A193T	DO43186	UCEC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.1944
p.A200S	TCGA-UB-A7MB	LIHC	TCGA	DSGRKDS	DEG_SCF_TRCP1_1	0.7588
p.A200S	DO52318	LIHC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7588
p.A193S	TCGA-VQ-AA6D	STAD	TCGA	DSGRKDS	DEG_SCF_TRCP1_1	0.1944
p.A193S	DO222392	STAD	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.1944
p.S202L	DO229010	COCA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.S202L	DO229016	COCA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.S202L	DO234285	ESAD	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.S202L	DO229353	LAML	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.S202L	DO230659	LAML	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.S202L	DO231140	LAML	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.S202L	DO228941	LICA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.S202L	DO228947	LICA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.S202L	DO230529	LUSC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.S202L	DO52365	LUSC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.S202L	DO231075	LUSC	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.7667
p.V196L	DO229008	LICA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.2778
p.I190V	DO44680	LICA	ICGC	DSGRKDS	DEG_SCF_TRCP1_1	0.1111
p.K208E	SIDM01137	Pancreatic Carcinoma	GDSC	DSGRKDS	DEG_SCF_TRCP1_1	0.6667
p.K208E	ACH-000235	Pancreatic Cancer	CCLE	DSGRKDS	DEG_SCF_TRCP1_1	0.6667
p.K208E	PANC-04-03	pancreas	COSMIC	DSGRKDS	DEG_SCF_TRCP1_1	0.6667
p.R195T	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	DSGRKDS	DEG_SCF_TRCP1_1	0.25
p.R195T	ACH-000809	Esophageal Cancer	CCLE	DSGRKDS	DEG_SCF_TRCP1_1	0.25
p.R195T	KYSE-410	oesophagus	COSMIC	DSGRKDS	DEG_SCF_TRCP1_1	0.25
p.L207F	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	DSGRKDS	DEG_SCF_TRCP1_1	0.25
p.L207F	ACH-000544	Esophageal Cancer	CCLE	DSGRKDS	DEG_SCF_TRCP1_1	0.25
p.L207F	OE21	oesophagus	COSMIC	DSGRKDS	DEG_SCF_TRCP1_1	0.25
p.S189C	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	DSGRKDS	DEG_SCF_TRCP1_1	0.5278
p.S189C	ACH-000353	Esophageal Cancer	CCLE	DSGRKDS	DEG_SCF_TRCP1_1	0.5278
p.S189C	TE-15	oesophagus	COSMIC	DSGRKDS	DEG_SCF_TRCP1_1	0.5278
p.K208N	LS-411N	large_intestine	COSMIC	DSGRKDS	DEG_SCF_TRCP1_1	0.6667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRKDS

Degron related mutations and impact score

Drug responses associated with MTRR mutations

All proteins holding degron of DSGRKDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBK8	Methionine synthase reductase	DEG_SCF_TRCP1_1	198:204	DSGRKDS	BTRC	0.9908	More...