DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPEY
Uniprot ID:
Q8IY63
Source protein:
Angiomotin-like protein 1
Source gene:
AMOTL1
Class:
ITCH
Location:
367:370
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9955
ASA_SCORE:
97.425
COIL:
0.9368
CONS_SCORE:
0.3844
DSS_SCORE:
0.4709
HELIX:
0.0323
FCONS_SCORE:
0.9239
RIG_SCORE:
0.67
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R375H
TCGA-06-6388
GBM
TCGA
PPEY
ITCH
0.1944
p.R375H
TCGA-HT-8105
LGG
TCGA
PPEY
ITCH
0.1944
p.R375H
DO14109
GBM
ICGC
PPEY
ITCH
0.1944
p.R375H
DO22299
LGG
ICGC
PPEY
ITCH
0.1944
p.Y370H
TCGA-A5-A2K5
UCEC
TCGA
PPEY
ITCH
0.7229
p.Y370H
DO41379
UCEC
ICGC
PPEY
ITCH
0.7229
p.D358N
DO222830
BTCA
ICGC
PPEY
ITCH
0.0833
p.P376Q
DO228971
LICA
ICGC
PPEY
ITCH
0.1667
p.C377Y
DO45299
LIRI
ICGC
PPEY
ITCH
0.1389
p.V361I
DO228550
MALY
ICGC
PPEY
ITCH
0.1667
p.P380L
SIDM00915
Small Cell Lung Carcinoma
GDSC
PPEY
ITCH
0.0556
p.P380L
SIDM00311
Mesothelioma
GDSC
PPEY
ITCH
0.0556
p.P380L
SIDM00136
Colorectal Carcinoma
GDSC
PPEY
ITCH
0.0556
p.P358L
COLO-320-HSR
large_intestine
COSMIC
PPEY
ITCH
0.0833
Drug responses associated with AMOTL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPEY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14964
Hepatocyte growth factor-regulated tyrosine kinase substrate
ITCH
234:237
PPEY
ITCH,NEDD4
0.9849
More...
O15047
Histone-lysine N-methyltransferase SETD1A
ITCH
643:646
PPEY
ITCH,NEDD4
0.6336
More...
O43364
Homeobox protein Hox-A2
ITCH
92:95
PPEY
ITCH,NEDD4
0.9063
More...
P20810
Calpastatin
ITCH
615:618
PPEY
ITCH,NEDD4
0.9885
More...
Q01850
Cerebellar degeneration-related protein 2
ITCH
419:422
PPEY
ITCH,NEDD4
0.9911
More...
Q03164
Histone-lysine N-methyltransferase 2A
ITCH
3788:3791
PPEY
ITCH,NEDD4
0.6997
More...
Q12849
G-rich sequence factor 1
ITCH
132:135
PPEY
ITCH,NEDD4
0.7614
More...
Q14118
Dystroglycan 1
ITCH
828:831
PPEY
ITCH,NEDD4
0.9964
More...
Q15678
Tyrosine-protein phosphatase non-receptor type 14
ITCH
749:752
PPEY
ITCH,NEDD4
0.9698
More...
Q15811
Intersectin-1
ITCH
300:303
PPEY
ITCH,NEDD4
0.9101
More...
Q4VCS5
Angiomotin
ITCH
239:242
PPEY
ITCH,NEDD4
0.9966
More...
Q4VCS5
Angiomotin
ITCH
284:287
PPEY
ITCH,NEDD4
0.9928
More...
Q58F21
Bromodomain testis-specific protein
ITCH
16:19
PPEY
ITCH,NEDD4
0.6067
More...
Q5T5X7
BEN domain-containing protein 3
ITCH
243:246
PPEY
ITCH,NEDD4
0.9695
More...
Q8IY63
Angiomotin-like protein 1
ITCH
310:313
PPEY
ITCH,NEDD4
0.9985
More...
Q8IY63
Angiomotin-like protein 1
ITCH
367:370
PPEY
ITCH,NEDD4
0.9955
More...
Q8N5I2
Arrestin domain-containing protein 1
ITCH
402:405
PPEY
ITCH,NEDD4
0.923
More...
Q8WZ42
Titin
ITCH
14140:14143
PPEY
ITCH,NEDD4
0.8834
More...
Q8WZ42
Titin
ITCH
19345:19348
PPEY
ITCH,NEDD4
0.8515
More...
Q8WZ42
Titin
ITCH
26437:26440
PPEY
ITCH,NEDD4
0.6728
More...
Q9NRQ2
Phospholipid scramblase 4
ITCH
30:33
PPEY
ITCH,NEDD4
0.9894
More...
Q9UBK8
Methionine synthase reductase
ITCH
246:249
PPEY
ITCH,NEDD4
0.9386
More...
O14668
Transmembrane gamma-carboxyglutamic acid protein 1
ITCH
193:196
PPEY
ITCH,NEDD4
0.9979
More...
O75153
Clustered mitochondria protein homolog
ITCH
186:189
PPEY
ITCH,NEDD4
0.9952
More...
P81408
Protein FAM189B
ITCH
252:255
PPEY
ITCH,NEDD4
0.9827
More...
Q96JP2
Unconventional myosin-XVB
ITCH
87:90
PPEY
ITCH,NEDD4
0.9288
More...
O60320
Protein FAM189A1
ITCH
251:254
PPEY
ITCH,NEDD4
0.909
More...
Q8TBH0
Arrestin domain-containing protein 2
ITCH
339:342
PPEY
ITCH,NEDD4
0.9109
More...
