DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: ITCH

Location: 14140:14143

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8834

ASA_SCORE: 77.35

COIL: 0.8838

CONS_SCORE: 0.6071

DSS_SCORE: 0.3059

HELIX: 0.088

FCONS_SCORE: 1.0799

RIG_SCORE: 0.7968

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M14145K	TCGA-34-5240	LUSC	TCGA	PPEY	ITCH	0.2778
p.P14147H	TCGA-AX-A2HD	UCEC	TCGA	PPEY	ITCH	0.2222
p.F14144C	TCGA-EO-A22U	UCEC	TCGA	PPEY	ITCH	0.3056
p.G14139S	TCGA-W3-A825	SKCM	TCGA	PPEY	ITCH	0.3056
p.Q14151R	TCGA-ZF-AA51	BLCA	TCGA	PPEY	ITCH	0.1111
p.E14139Q	DO224768	BRCA	ICGC	PPEY	ITCH	0.3056
p.V14153I	DO222709	COCA	ICGC	PPEY	ITCH	0.0556
p.V14153I	DO47787	STAD	ICGC	PPEY	ITCH	0.0556
p.V14153I	DO43843	UCEC	ICGC	PPEY	ITCH	0.0556
p.F14132V	DO234195	ESAD	ICGC	PPEY	ITCH	0.1111
p.P14141A	DO48712	LIRI	ICGC	PPEY	ITCH	0.7503
p.D14144N	DO220884	MELA	ICGC	PPEY	ITCH	0.3056
p.D14144N	DO222702	MELA	ICGC	PPEY	ITCH	0.3056
p.D14144N	DO47781	STAD	ICGC	PPEY	ITCH	0.3056
p.V14153A	DO47777	STAD	ICGC	PPEY	ITCH	0.0556
p.A14147V	DO41999	UCEC	ICGC	PPEY	ITCH	0.2222
p.M14145V	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PPEY	ITCH	0.2778
p.M14145V	ACH-002263	Esophageal Cancer	CCLE	PPEY	ITCH	0.2778
p.M14145V	KYSE-220	oesophagus	COSMIC	PPEY	ITCH	0.2778
p.L14148P	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPEY	ITCH	0.1944
p.L14148P	ACH-002062	Lymphoma	CCLE	PPEY	ITCH	0.1944
p.L14148P	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	PPEY	ITCH	0.1944
p.K14138N	CW-2	large_intestine	COSMIC	PPEY	ITCH	0.2778
p.S14143N	IM-95	stomach	COSMIC	PPEY	ITCH	0.7069
p.T14142N	NCI-H23	lung	COSMIC	PPEY	ITCH	0.7055
p.K14138R	SNU-407	large_intestine	COSMIC	PPEY	ITCH	0.2778
p.E14138G	OVCA420	ovary	COSMIC	PPEY	ITCH	0.2778
p.T14140I	639-V	urinary_tract	COSMIC	PPEY	ITCH	0.7078

Drug responses associated with TTN mutations

All proteins holding degron of PPEY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	ITCH	234:237	PPEY	ITCH,NEDD4	0.9849	More...
O15047	Histone-lysine N-methyltransferase SETD1A	ITCH	643:646	PPEY	ITCH,NEDD4	0.6336	More...
O43364	Homeobox protein Hox-A2	ITCH	92:95	PPEY	ITCH,NEDD4	0.9063	More...
P20810	Calpastatin	ITCH	615:618	PPEY	ITCH,NEDD4	0.9885	More...
Q01850	Cerebellar degeneration-related protein 2	ITCH	419:422	PPEY	ITCH,NEDD4	0.9911	More...
Q03164	Histone-lysine N-methyltransferase 2A	ITCH	3788:3791	PPEY	ITCH,NEDD4	0.6997	More...
Q12849	G-rich sequence factor 1	ITCH	132:135	PPEY	ITCH,NEDD4	0.7614	More...
Q14118	Dystroglycan 1	ITCH	828:831	PPEY	ITCH,NEDD4	0.9964	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	ITCH	749:752	PPEY	ITCH,NEDD4	0.9698	More...
Q15811	Intersectin-1	ITCH	300:303	PPEY	ITCH,NEDD4	0.9101	More...
Q4VCS5	Angiomotin	ITCH	239:242	PPEY	ITCH,NEDD4	0.9966	More...
Q4VCS5	Angiomotin	ITCH	284:287	PPEY	ITCH,NEDD4	0.9928	More...
Q58F21	Bromodomain testis-specific protein	ITCH	16:19	PPEY	ITCH,NEDD4	0.6067	More...
Q5T5X7	BEN domain-containing protein 3	ITCH	243:246	PPEY	ITCH,NEDD4	0.9695	More...
Q8IY63	Angiomotin-like protein 1	ITCH	310:313	PPEY	ITCH,NEDD4	0.9985	More...
Q8IY63	Angiomotin-like protein 1	ITCH	367:370	PPEY	ITCH,NEDD4	0.9955	More...
Q8N5I2	Arrestin domain-containing protein 1	ITCH	402:405	PPEY	ITCH,NEDD4	0.923	More...
Q8WZ42	Titin	ITCH	14140:14143	PPEY	ITCH,NEDD4	0.8834	More...
Q8WZ42	Titin	ITCH	19345:19348	PPEY	ITCH,NEDD4	0.8515	More...
Q8WZ42	Titin	ITCH	26437:26440	PPEY	ITCH,NEDD4	0.6728	More...
Q9NRQ2	Phospholipid scramblase 4	ITCH	30:33	PPEY	ITCH,NEDD4	0.9894	More...
Q9UBK8	Methionine synthase reductase	ITCH	246:249	PPEY	ITCH,NEDD4	0.9386	More...
O14668	Transmembrane gamma-carboxyglutamic acid protein 1	ITCH	193:196	PPEY	ITCH,NEDD4	0.9979	More...
O75153	Clustered mitochondria protein homolog	ITCH	186:189	PPEY	ITCH,NEDD4	0.9952	More...
P81408	Protein FAM189B	ITCH	252:255	PPEY	ITCH,NEDD4	0.9827	More...
Q96JP2	Unconventional myosin-XVB	ITCH	87:90	PPEY	ITCH,NEDD4	0.9288	More...
O60320	Protein FAM189A1	ITCH	251:254	PPEY	ITCH,NEDD4	0.909	More...
Q8TBH0	Arrestin domain-containing protein 2	ITCH	339:342	PPEY	ITCH,NEDD4	0.9109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPEY

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of PPEY