DegronMD - O75153(CLUH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D183N	TCGA-AJ-A23M	UCEC	TCGA	PPEY	ITCH	186:189	Mutation rewiring degron network	0.25
p.D183N	DO41217	UCEC	ICGC	PPEY	ITCH	186:189	Mutation rewiring degron network	0.25
p.A54T	TCGA-BH-A18G	BRCA	TCGA	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation altering degron motif	0.7139
p.A54T	DO3686	BRCA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation altering degron motif	0.7139
p.A54T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation altering degron motif	0.7139
p.A54T	ACH-001669	Leukemia	CCLE	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation altering degron motif	0.7139
p.A54T	ACH-002238	Leukemia	CCLE	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation altering degron motif	0.7139
p.A54T	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation altering degron motif	0.7139
p.R197Q	TCGA-CG-5721	STAD	TCGA	PPEY	ITCH	186:189	Mutation rewiring degron network	0.1111
p.R197Q	DO38192	STAD	ICGC	PPEY	ITCH	186:189	Mutation rewiring degron network	0.1111
p.M179I	TCGA-FS-A1ZB	SKCM	TCGA	PPEY	ITCH	186:189	Mutation rewiring degron network	0.1389
p.M179I	DO37886	SKCM	ICGC	PPEY	ITCH	186:189	Mutation rewiring degron network	0.1389
p.Q44E	TCGA-ZF-AA4N	BLCA	TCGA	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation rewiring degron network	0.0833
p.Q44E	DO219082	BLCA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation rewiring degron network	0.0833
p.E178D	DO48213	ESCA	ICGC	PPEY	ITCH	186:189	Mutation rewiring degron network	0.1111
p.Q67H	DO228377	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation rewiring degron network	0.25
p.Q71R	DO228422	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation rewiring degron network	0.1389
p.D180E	DO228952	LICA	ICGC	PPEY	ITCH	186:189	Mutation rewiring degron network	0.1667
p.T46K	DO229015	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation rewiring degron network	0.1389
p.T46K	DO229026	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation rewiring degron network	0.1389
p.P59T	DO229029	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation altering degron motif	0.5919
p.S49Y	DO229037	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation rewiring degron network	0.2222
p.S65F	DO222749	MELA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation rewiring degron network	0.3056
p.S65F	DO221048	WT	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	53:64	Mutation rewiring degron network	0.3056
p.G176S	ACH-000966	Ovarian Cancer	CCLE	PPEY	ITCH	186:189	Mutation rewiring degron network	0.0556

Kaplan plot for CLUH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLUH

UniProt ID: O75153

Entrez ID: 23277

Protein name: Clustered mitochondria protein homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLUH in