DegronMD

Uniprot ID: O75153

Source protein: Clustered mitochondria protein homolog

Source gene: CLUH

Class: DEG_ODPH_VHL_1

Location: 53:64

E3 ligase: VHL

DEGRON score: 0.7376

ASA_SCORE: 55.3167

COIL: 0.5046

CONS_SCORE: 0.379

DSS_SCORE: 0.2846

HELIX: 0.0084

FCONS_SCORE: 0.9019

RIG_SCORE: 0.7886

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A54T	TCGA-BH-A18G	BRCA	TCGA	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.7139
p.A54T	DO3686	BRCA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.7139
p.A54T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.7139
p.A54T	ACH-001669	Leukemia	CCLE	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.7139
p.A54T	ACH-002238	Leukemia	CCLE	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.7139
p.A54T	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.7139
p.Q44E	TCGA-ZF-AA4N	BLCA	TCGA	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.0833
p.Q44E	DO219082	BLCA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.0833
p.Q67H	DO228377	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.25
p.Q71R	DO228422	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.1389
p.T46K	DO229015	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.1389
p.T46K	DO229026	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.1389
p.P59T	DO229029	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.5919
p.S49Y	DO229037	LICA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.2222
p.S65F	DO222749	MELA	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.3056
p.S65F	DO221048	WT	ICGC	LAPGIEPFSLQV	DEG_ODPH_VHL_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75153	Clustered mitochondria protein homolog	DEG_ODPH_VHL_1	53:64	LAPGIEPFSLQV	VHL	0.7376	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons