DegronMD - Q8IY63(AMOTL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R375H	TCGA-06-6388	GBM	TCGA	PPEY	ITCH	367:370	Mutation rewiring degron network	0.1944
p.R375H	TCGA-HT-8105	LGG	TCGA	PPEY	ITCH	367:370	Mutation rewiring degron network	0.1944
p.R375H	DO14109	GBM	ICGC	PPEY	ITCH	367:370	Mutation rewiring degron network	0.1944
p.R375H	DO22299	LGG	ICGC	PPEY	ITCH	367:370	Mutation rewiring degron network	0.1944
p.M321I	TCGA-77-8136	LUSC	TCGA	PPEY	ITCH	310:313	Mutation rewiring degron network	0.1111
p.M321I	DO26593	LUSC	ICGC	PPEY	ITCH	310:313	Mutation rewiring degron network	0.1111
p.G897V	TCGA-78-7536	LUAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.2778
p.Y370H	TCGA-A5-A2K5	UCEC	TCGA	PPEY	ITCH	367:370	Mutation altering degron motif	0.7229
p.Y370H	DO41379	UCEC	ICGC	PPEY	ITCH	367:370	Mutation altering degron motif	0.7229
p.A914S	TCGA-AA-A010	COAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.1111
p.F315L	TCGA-BT-A42C	BLCA	TCGA	PPEY	ITCH	310:313	Mutation rewiring degron network	0.2778
p.F315L	DO49725	BLCA	ICGC	PPEY	ITCH	310:313	Mutation rewiring degron network	0.2778
p.R898W	TCGA-CD-A4MJ	STAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.3056
p.R898W	TCGA-CG-4474	STAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.3056
p.P323T	TCGA-D3-A2J6	SKCM	TCGA	PPEY	ITCH	310:313	Mutation rewiring degron network	0.0556
p.P323T	DO37901	SKCM	ICGC	PPEY	ITCH	310:313	Mutation rewiring degron network	0.0556
p.M320I	TCGA-DK-A1A5	BLCA	TCGA	PPEY	ITCH	310:313	Mutation rewiring degron network	0.1389
p.M320I	DO477	BLCA	ICGC	PPEY	ITCH	310:313	Mutation rewiring degron network	0.1389
p.A891T	TCGA-G4-6304	COAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.1111
p.G897S	TCGA-SS-A7HO	COAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.2778
p.D358N	DO222830	BTCA	ICGC	PPEY	ITCH	367:370	Mutation rewiring degron network	0.0833
p.P376Q	DO228971	LICA	ICGC	PPEY	ITCH	367:370	Mutation rewiring degron network	0.1667
p.G301V	DO228986	LICA	ICGC	PPEY	ITCH	310:313	Mutation rewiring degron network	0.0833
p.C377Y	DO45299	LIRI	ICGC	PPEY	ITCH	367:370	Mutation rewiring degron network	0.1389
p.V361I	DO228550	MALY	ICGC	PPEY	ITCH	367:370	Mutation rewiring degron network	0.1667
p.P306S	DO220898	MELA	ICGC	PPEY	ITCH	310:313	Mutation rewiring degron network	0.2222
p.F315C	DO48909	PBCA	ICGC	PPEY	ITCH	310:313	Mutation rewiring degron network	0.2778
p.P380L	SIDM00915	Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	367:370	Mutation rewiring degron network	0.0556
p.P380L	SIDM00311	Mesothelioma	GDSC	PPEY	ITCH	367:370	Mutation rewiring degron network	0.0556
p.P380L	SIDM00136	Colorectal Carcinoma	GDSC	PPEY	ITCH	367:370	Mutation rewiring degron network	0.0556
p.P309L	SIDM00885	Breast Carcinoma	GDSC	PPEY	ITCH	310:313	Mutation rewiring degron network	0.3056
p.P309L	SIDM00869	Non-Cancerous	GDSC	PPEY	ITCH	310:313	Mutation rewiring degron network	0.3056
p.P309L	ACH-000111	Breast Cancer	CCLE	PPEY	ITCH	310:313	Mutation rewiring degron network	0.3056
p.P309L	ACH-002373	Non-Cancerous	CCLE	PPEY	ITCH	310:313	Mutation rewiring degron network	0.3056
p.R896L	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.25
p.R896L	ACH-000744	Lung Cancer	CCLE	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.25
p.R896L	NCI-H1623	lung	COSMIC	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.25
p.R898Q	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.3056
p.R898Q	ACH-000787	Lung Cancer	CCLE	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.3056
p.R898Q	LXF-289	lung	COSMIC	LSTTPAHS	DEG_SCF_FBW7_1	899:906	Mutation rewiring degron network	0.3056
p.P358L	COLO-320-HSR	large intestine	COSMIC	PPEY	ITCH	367:370	Mutation rewiring degron network	0.0833
p.Q303E	DJM-1	skin	COSMIC	PPEY	ITCH	310:313	Mutation rewiring degron network	0.1389

Kaplan plot for AMOTL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMOTL1

UniProt ID: Q8IY63

Entrez ID: 154810

Protein name: Angiomotin-like protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMOTL1 in