DegronMD

Uniprot ID: Q8IY63

Source protein: Angiomotin-like protein 1

Source gene: AMOTL1

Class: DEG_SCF_FBW7_1

Location: 899:906

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 72.4875

COIL: 0.8795

CONS_SCORE: 0.3658

DSS_SCORE: 0.6467

HELIX: 0.0353

FCONS_SCORE: 1.1241

RIG_SCORE: 0.6042

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G897V	TCGA-78-7536	LUAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	0.2778
p.A914S	TCGA-AA-A010	COAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	0.1111
p.R898W	TCGA-CD-A4MJ	STAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	0.3056
p.R898W	TCGA-CG-4474	STAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	0.3056
p.A891T	TCGA-G4-6304	COAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	0.1111
p.G897S	TCGA-SS-A7HO	COAD	TCGA	LSTTPAHS	DEG_SCF_FBW7_1	0.2778
p.R896L	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	LSTTPAHS	DEG_SCF_FBW7_1	0.25
p.R896L	ACH-000744	Lung Cancer	CCLE	LSTTPAHS	DEG_SCF_FBW7_1	0.25
p.R896L	NCI-H1623	lung	COSMIC	LSTTPAHS	DEG_SCF_FBW7_1	0.25
p.R898Q	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	LSTTPAHS	DEG_SCF_FBW7_1	0.3056
p.R898Q	ACH-000787	Lung Cancer	CCLE	LSTTPAHS	DEG_SCF_FBW7_1	0.3056
p.R898Q	LXF-289	lung	COSMIC	LSTTPAHS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY63	Angiomotin-like protein 1	DEG_SCF_FBW7_1	899:906	LSTTPAHS	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons