DegronMD - Q12849(GRSF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P133S	TCGA-64-5775	LUAD	TCGA	PPEY	ITCH	132:135	Mutation altering degron motif	0.6752
p.P130A	TCGA-66-2788	LUSC	TCGA	PPEY	ITCH	132:135	Mutation rewiring degron network	0.2778
p.P130A	ACH-000773	Lymphoma	CCLE	PPEY	ITCH	132:135	Mutation rewiring degron network	0.2778
p.L126V	TCGA-86-8073	LUAD	TCGA	PPEY	ITCH	132:135	Mutation rewiring degron network	0.1667
p.P139L	TCGA-EB-A4IS	SKCM	TCGA	PPEY	ITCH	132:135	Mutation rewiring degron network	0.2222
p.L129P	TCGA-MH-A55W	KIRP	TCGA	PPEY	ITCH	132:135	Mutation rewiring degron network	0.25
p.L126P	TCGA-WQ-A9G7	LIHC	TCGA	PPEY	ITCH	132:135	Mutation rewiring degron network	0.1667
p.R123K	DO224847	BRCA	ICGC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.0833
p.R123K	DO227473	BRCA	ICGC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.0833
p.E136K	DO49964	CESC	ICGC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.3056
p.A131D	DO229038	LICA	ICGC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.3056
p.L145V	DO23612	LUAD	ICGC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.0556
p.E130D	DO43306	UCEC	ICGC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.2778
p.R126Q	DO41379	UCEC	ICGC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.1667
p.R126Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPEY	ITCH	132:135	Mutation rewiring degron network	0.1667
p.A138T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.25
p.A138T	ACH-002272	Lymphoma	CCLE	PPEY	ITCH	132:135	Mutation rewiring degron network	0.25
p.A138T	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.25
p.K127N	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPEY	ITCH	132:135	Mutation rewiring degron network	0.1944
p.N142I	TMK-1	stomach	COSMIC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.1389
p.E143K	MDST8	large intestine	COSMIC	PPEY	ITCH	132:135	Mutation rewiring degron network	0.1111

Kaplan plot for GRSF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRSF1

UniProt ID: Q12849

Entrez ID: 2926

Protein name: G-rich sequence factor 1 (GRSF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRSF1 in