DegronMD - Q4VCS5(AMOT)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A289T	TCGA-2W-A8YY	CESC	TCGA	PPEY	ITCH	284:287	Mutation rewiring degron network	0.2778
p.A289T	DO223732	CESC	ICGC	PPEY	ITCH	284:287	Mutation rewiring degron network	0.2778
p.Q1002L	TCGA-55-8510	LUAD	TCGA	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.1111
p.Q1002L	DO24339	LUAD	ICGC	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.1111
p.V1010M	TCGA-73-4668	LUAD	TCGA	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation altering degron motif	0.6097
p.A1025D	TCGA-A6-6781	COAD	TCGA	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.1111
p.A1025D	DO8447	COAD	ICGC	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.1111
p.Y242C	TCGA-AA-3949	COAD	TCGA	PPEY	ITCH	239:242	Mutation altering degron motif	0.7087
p.Y242C	DO7798	COAD	ICGC	PPEY	ITCH	239:242	Mutation altering degron motif	0.7087
p.S842L	TCGA-AJ-A3EK	UCEC	TCGA	PPSTPLLS	DEG_SCF_FBW7_1	845:852	Mutation blocking phosphorylation signal	0.6944
p.T212K	TCGA-AR-A1AR	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.6195
p.T212K	DO4893	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.6195
p.A1007V	TCGA-AX-A0J0	UCEC	TCGA	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.25
p.A1007V	DO41133	UCEC	ICGC	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.25
p.D206Y	TCGA-B5-A1MR	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.D206Y	DO41758	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.A293V	TCGA-B5-A3FA	UCEC	TCGA	PPEY	ITCH	284:287	Mutation rewiring degron network	0.1667
p.A293V	DO52402	UCEC	ICGC	PPEY	ITCH	284:287	Mutation rewiring degron network	0.1667
p.A293V	DO42673	UCEC	ICGC	PPEY	ITCH	284:287	Mutation rewiring degron network	0.1667
p.T212A	TCGA-CA-6717	COAD	TCGA	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.6028
p.T212A	DO8264	COAD	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.6028
p.K856R	TCGA-DM-A1D8	COAD	TCGA	PPSTPLLS	DEG_SCF_FBW7_1	845:852	Mutation substituting flanking lysine	0.3333
p.S839F	TCGA-EB-A5FP	SKCM	TCGA	PPSTPLLS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1667
p.S213C	TCGA-EO-A2CG	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7541
p.S213C	DO42185	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7541
p.P225S	TCGA-UC-A7PG	CESC	TCGA	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.P225S	DO51615	CESC	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.E1026K	TCGA-ZF-A9RL	BLCA	TCGA	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.0833
p.R230S	DO225106	BRCA	ICGC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.0833
p.R283K	DO8842	COAD	ICGC	PPEY	ITCH	284:287	Mutation rewiring degron network	0.3056
p.R217H	DO219908	DLBC	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.L287V	DO222306	DLBC	ICGC	PPEY	ITCH	284:287	Mutation altering degron motif	0.6765
p.R219W	DO233903	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking ubiquitination signal	0.6667
p.Q274E	DO15454	HNSC	ICGC	PPEY	ITCH	284:287	Mutation rewiring degron network	0.0556
p.A295S	DO14343	HNSC	ICGC	PPEY	ITCH	284:287	Mutation rewiring degron network	0.1111
p.A295S	NCI-H1573	lung	COSMIC	PPEY	ITCH	284:287	Mutation rewiring degron network	0.1111
p.Q250K	DO229022	LICA	ICGC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.1111
p.S852L	DO229027	LICA	ICGC	PPSTPLLS	DEG_SCF_FBW7_1	845:852	Mutation altering degron motif	0.7667
p.R224K	DO218923	LUAD	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0833
p.Q296H	DO45422	LUAD	ICGC	PPEY	ITCH	284:287	Mutation rewiring degron network	0.0833
p.P249L	DO222880	MELA	ICGC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.1389
p.P249L	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.1389
p.P249L	ACH-000893	Lung Cancer	CCLE	PPEY	ITCH	239:242	Mutation rewiring degron network	0.1389
p.P249L	NCI-H1651	lung	COSMIC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.1389
p.P248S	DO35118	PACA	ICGC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.1667
p.R236Q	DO48539	PAEN	ICGC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.25
p.R234H	DO51407	PRAD	ICGC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.1944
p.E216K	DO218850	SKCA	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056
p.S213I	DO234002	THCA	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7341
p.A220V	DO41199	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.G236D	DO42825	UCEC	ICGC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.25
p.A295D	DO42793	UCEC	ICGC	PPEY	ITCH	284:287	Mutation rewiring degron network	0.1111
p.A1007S	SIDM00419	Ewing's Sarcoma	GDSC	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.25
p.A1007S	ACH-000424	Bone Cancer	CCLE	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.25
p.A1007S	TC-71	bone	COSMIC	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.25
p.A220T	SIDM01057	Acute Myeloid Leukemia	GDSC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.A220T	GDM-1	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.D206N	SIDM00590	Oral Cavity Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.D206N	SIDM00124	Kidney Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.D206N	ACH-000472	Head and Neck Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.D206N	ACH-000555	Kidney Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.D206N	A498	kidney	COSMIC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.D206N	HSC-2	upper aerodigestive tract	COSMIC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.P284S	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PPEY	ITCH	284:287	Mutation altering degron motif	0.6752
p.P284S	ACH-000824	Esophageal Cancer	CCLE	PPEY	ITCH	284:287	Mutation altering degron motif	0.6752
p.P284S	KYSE-510	oesophagus	COSMIC	PPEY	ITCH	284:287	Mutation altering degron motif	0.6752
p.L851V	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PPSTPLLS	DEG_SCF_FBW7_1	845:852	Mutation altering degron motif	0.5654
p.L851V	ACH-000589	Lung Cancer	CCLE	PPSTPLLS	DEG_SCF_FBW7_1	845:852	Mutation altering degron motif	0.5654
p.L851V	NCI-H1437	lung	COSMIC	PPSTPLLS	DEG_SCF_FBW7_1	845:852	Mutation altering degron motif	0.5654
p.V1027A	SIDM00490	Glioma	GDSC	VAPTPAPT	DEG_SCF_FBW7_1	1010:1017	Mutation rewiring degron network	0.0556
p.S215I	ACH-000127	Bladder Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7341
p.Q294L	ACH-000945	Lung Cancer	CCLE	PPEY	ITCH	284:287	Mutation rewiring degron network	0.1389
p.Y246N	LNCaP-Clone-FGC	prostate	COSMIC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.2222
p.L247P	LK-2	lung	COSMIC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.1944
p.E212K	MCC13	skin	COSMIC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7022
p.L201I	A253	salivary gland	COSMIC	PTSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.Q233H	ME-180	cervix	COSMIC	PPEY	ITCH	239:242	Mutation rewiring degron network	0.1667
p.R282C	HCE-4	oesophagus	COSMIC	PPEY	ITCH	284:287	Mutation rewiring degron network	0.2778
p.L287Q	L-540	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	284:287	Mutation altering degron motif	0.7765
p.Q841P	NCI-H661	lung	COSMIC	PPSTPLLS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMOT

UniProt ID: Q4VCS5

Entrez ID: 154796

Protein name: Angiomotin

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for AMOT in